SOX11

Description		SRY-box transcription factor 11
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Lens Morphogenesis In Camera-type Eye Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Nervous System Development Brain Development Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Oligodendrocyte Development Glial Cell Proliferation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Spinal Cord Development Glial Cell Development Cell Differentiation Neuron Differentiation Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Hippo Signaling Skeletal Muscle Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Sympathetic Nervous System Development Embryonic Digestive Tract Morphogenesis Camera-type Eye Morphogenesis Embryonic Skeletal System Morphogenesis Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Neurogenesis Hard Palate Development Soft Palate Development Negative Regulation Of Glial Cell Proliferation Ventricular Septum Morphogenesis Lung Morphogenesis Neuroepithelial Cell Differentiation Eyelid Development In Camera-type Eye Cornea Development In Camera-type Eye Closure Of Optic Fissure Positive Regulation Of Stem Cell Proliferation Negative Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Lens Epithelial Cell Proliferation
Pathways
Drugs
Diseases
GWAS		Age at first birth ( 34211149) Automobile speeding propensity ( 30643258) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic kidney disease ( 20383146) Crohn's disease ( 23266558) Diabetic kidney disease ( 26305897) Hip circumference ( 25673412) Intraocular pressure ( 29617998) Multisite chronic pain ( 33830993) Obesity in adult survivors of childhood cancer exposed to cranial radiation ( 25963547) Obesity-related traits ( 23251661) Proteinuria and chronic kidney disease ( 26420894) Tuberculosis ( 24057671) Type 2 diabetes ( 31118516)
Interacting Genes		3 interacting genes: MTNR1A POU3F2 POU3F3
Entrez ID		6664
HPRD ID		02940
Ensembl ID		ENSG00000176887
Uniprot IDs		P35716
PDB IDs		6T78 6T7A 6T7C 6T7D
Enriched GO Terms of Interacting Partners?		Forebrain Ventricular Zone Progenitor Cell Division Cerebral Cortex Radially Oriented Cell Migration Cerebral Cortex Cell Migration Telencephalon Cell Migration Forebrain Cell Migration Metanephric DCT Cell Differentiation Metanephric Macula Densa Development Neurohypophysis Development Metanephric Thick Ascending Limb Development Metanephric Loop Of Henle Development Forebrain Astrocyte Development Brain Development Melatonin Receptor Activity Metanephric Ascending Thin Limb Development Hypothalamus Cell Differentiation Loop Of Henle Development Urea Transmembrane Transport Sequence-specific DNA Binding Cell Division HMG Box Domain Binding Metanephric Nephron Tubule Development Urea Transport Metanephric Tubule Development Metanephric Epithelium Development Hormone Binding Neuroendocrine Cell Differentiation Astrocyte Development Schwann Cell Development Nervous System Development Myelination In Peripheral Nervous System Mating Behavior Nephron Tubule Development DNA-binding Transcription Factor Activity Renal Tubule Development One-carbon Compound Transport Neuron Fate Specification Tissue Development Cell Differentiation Involved In Kidney Development Reproductive Behavior Positive Regulation Of Multicellular Organism Growth Neuroepithelial Cell Differentiation Neuron Fate Commitment Cell Migration Positive Regulation Of Cell Population Proliferation G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding System Development Cell Motility Glial Cell Development Chromatin
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