PDIA6

Description		protein disulfide isomerase family A member 6
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GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Plasma Membrane Cilium Membrane Centriolar Satellite Endoplasmic Reticulum Chaperone Complex Ciliary Basal Body Melanosome Extracellular Exosome
	Molecular Function	Protein Disulfide Isomerase Activity Protein Binding Protein-disulfide Reductase Activity Isomerase Activity
	Biological Process	Protein Folding Response To Endoplasmic Reticulum Stress
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Novel Interacting Genes		3 novel interacting genes: CEP250 NPC2 THAP1
Interacting Genes		19 interacting genes: ATP13A2 CASP8 CLN8 CSNK2A1 GET3 LGALS9 LINC01554 MC4R MTNR1A MTNR1B OGT PDE4B SGTB SLC22A2 SLC2A4 SUMO4 TRIM14 UBE3A VKORC1
Entrez ID		10130
HPRD ID		07504
Ensembl ID		ENSG00000143870
Uniprot IDs		A0A384NPU5 Q15084
PDB IDs		1X5D 3VWW 3W8J 4EF0 4GWR 8CPQ
Enriched GO Terms of Interacting Partners?		Melatonin Receptor Activity Polyamine Transmembrane Transport Chemical Homeostasis Regulation Of Proteolysis Homeostatic Process Regulation Of Neuron Apoptotic Process Protein Localization To Vacuole Rhythmic Process Neurotransmitter Reuptake Sin3-type Complex
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