PSMD8 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 11163772)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		PSMD8	UCHL5
Description		proteasome 26S subunit, non-ATPase 8	ubiquitin C-terminal hydrolase L5
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Nucleoplasm Cytosol Proteasome Regulatory Particle Proteasome Regulatory Particle, Lid Subcomplex Proteasome Accessory Complex Protein-containing Complex	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Protein Binding	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Assembly of the pre-replicative complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling KEAP1-NFE2L2 pathway GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Degradation of CDH1 Somitogenesis Antigen processing: Ubiquitination & Proteasome degradation Proteasome assembly Proteasome assembly GSK3B-mediated proteasomal degradation of PD-L1(CD274) SPOP-mediated proteasomal degradation of PD-L1(CD274) AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274) Degradation of CRY and PER proteins Degradation of CRY and PER proteins Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		HDL cholesterol levels ( 32203549)	Cannabis dependence ( 21668797)
Interacting Genes		10 interacting genes: GLP1R GSK3A GSK3B MTNR1B PRDX6 SHC3 SMAD2 SMAD9 UBC UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		5714	51377
HPRD ID		10171	10293
Ensembl ID		ENSG00000099341	ENSG00000116750
Uniprot IDs		P48556 V9HW09	Q5LJA5 Q9Y5K5
PDB IDs		5GJQ 5GJR 5L4K 5LN3 5M32 5T0C 5T0G 5T0H 5T0I 5T0J 5VFP 5VFQ 5VFR 5VFS 5VFT 5VFU 5VGZ 5VHF 5VHH 5VHI 5VHS 6MSB 6MSD 6MSG 6MSH 6MSJ 6MSK 6WJD 6WJN 7QXN 7QXP 7QXU 7QXW 7QXX 7QY7 7QYA 7QYB 7W37 7W38 7W39 7W3A 7W3B 7W3C 7W3F 7W3G 7W3H 7W3I 7W3J 7W3K 7W3M 8CVT 8JRI 8JRT 8JTI 8K0G 8USB 8USC 9E8G 9E8H 9E8I 9E8J 9E8K 9E8L 9E8N 9E8O 9E8Q	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glycogen (starch) Synthase Activity Regulation Of Glycogen (starch) Synthase Activity Tau Protein Binding Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cellular Response To Interleukin-3 SMAD Protein Complex Regulation Of Type B Pancreatic Cell Development Heteromeric SMAD Protein Complex Negative Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Beta-catenin Destruction Complex Protein Kinase A Catalytic Subunit Binding I-SMAD Binding Tau-protein Kinase Activity Ubiquitin Protein Ligase Binding Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway SMAD Protein Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Viral Protein Processing Positive Regulation Of Mitochondrial Membrane Permeability Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Membrane Permeability Negative Regulation Of Catalytic Activity Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Glycogen Metabolic Process Negative Regulation Of Multicellular Organismal Process Glucagon-like Peptide 1 Receptor Activity Negative Regulation Of UDP-glucose Catabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Microtubule Anchoring At Centrosome Oxidized DNA Binding Regulation Of Proteasomal Protein Catabolic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Positive Regulation Of RNA Metabolic Process Glycogen Metabolic Process Regulation Of Mitochondrial Membrane Permeability Excitatory Postsynaptic Potential Positive Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Superior Temporal Gyrus Development Negative Regulation Of Mesenchymal Stem Cell Differentiation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Homomeric SMAD Protein Complex Susceptibility To T Cell Mediated Cytotoxicity Positive Regulation Of Respiratory Burst Involved In Inflammatory Response Negative Regulation Of Protein ADP-ribosylation	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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