PHKA2 and UROD

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHKA2	UROD
Description		phosphorylase kinase regulatory subunit alpha 2	uroporphyrinogen decarboxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Phosphorylase Kinase Complex Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Phosphorylase Kinase Activity Protein Binding Calmodulin Binding	Uroporphyrinogen Decarboxylase Activity Protein Binding Lyase Activity Carboxy-lyase Activity
	Biological Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Generation Of Precursor Metabolites And Energy Protein Modification Process	Porphyrin-containing Compound Metabolic Process Porphyrin-containing Compound Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Heme A Biosynthetic Process Heme B Biosynthetic Process Porphyrin-containing Compound Catabolic Process Heme Metabolic Process Heme O Biosynthetic Process
Pathways		Glycogen breakdown (glycogenolysis)	Heme biosynthesis
Drugs			Coproporphyrin I Coproporphyrinogen III
Diseases		Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)	Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Interacting Genes		4 interacting genes: PHKB RAF1 SMAD9 UROD	11 interacting genes: CHD3 EGFR FAF1 FBXO7 HMGXB4 LRATD2 PHKA2 PILRA RUNX1 TSSK3 VIM
Entrez ID		5256	7389
HPRD ID		02380	01441
Ensembl ID		ENSG00000044446	ENSG00000126088
Uniprot IDs		P46019	A0A494C0Q8 P06132
PDB IDs			1JPH 1JPI 1JPK 1R3Q 1R3R 1R3S 1R3T 1R3V 1R3W 1R3Y 1URO 2Q6Z 2Q71 3GVQ 3GVR 3GVV 3GVW 3GW0 3GW3
Enriched GO Terms of Interacting Partners?		Heteromeric SMAD Protein Complex SMAD Protein Complex Phosphorylase Kinase Complex Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adenylate Cyclase Activator Activity ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Death-inducing Signaling Complex Assembly Heme O Biosynthetic Process Porphyrin-containing Compound Catabolic Process Uroporphyrinogen Decarboxylase Activity Heme A Biosynthetic Process Protoporphyrinogen IX Biosynthetic Process Heme B Biosynthetic Process Protoporphyrinogen IX Metabolic Process Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway SMAD Protein Signal Transduction Intracellular Chemical Homeostasis I-SMAD Binding Response To Muscle Stretch Type B Pancreatic Cell Proliferation Schwann Cell Development ERBB2 Signaling Pathway MAP Kinase Kinase Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Face Development Pseudopodium Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Carboxy-lyase Activity Cellular Response To BMP Stimulus Neurotrophin Signaling Pathway Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Thyroid Gland Development Cellular Homeostasis Enzyme-linked Receptor Protein Signaling Pathway Insulin-like Growth Factor Receptor Signaling Pathway Heme Metabolic Process	Positive Regulation Of Collagen Biosynthetic Process Regulation Of Collagen Metabolic Process Regulation Of Collagen Biosynthetic Process Positive Regulation Of DNA Replication Multivesicular Body, Internal Vesicle Lumen Chondroitin Sulfate Proteoglycan Binding Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Negative Regulation Of Lymphocyte Differentiation
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