PEX10 and CGRRF1

Number of citations of the paper that reports this interaction (PubMedID 22493164)
44

Data Source:
BioGRID (two hybrid)

		PEX10	CGRRF1
Description		peroxisomal biogenesis factor 10	cell growth regulator with ring finger domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Membrane	Nucleus Nucleoplasm Endoplasmic Reticulum
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release	Negative Regulation Of Cell Population Proliferation Negative Regulation Of Cell Growth Regulation Of Cell Cycle
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import
Drugs
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Body mass index ( 26426971) Liver enzyme levels (alkaline phosphatase) ( 33972514) Non-obstructive azoospermia ( 22197933)	Dental caries ( 23259602) Monobrow thickness ( 26926045) Night sleep phenotypes ( 27126917)
Interacting Genes		10 interacting genes: CGRRF1 HNRNPD LIG4 MKRN3 PCGF6 PEX12 PEX19 PEX2 PEX5 UBE2I	32 interacting genes: AGR3 BET1 CD72 CDIPT CREB3 CYB5B FAM241B FAXDC2 FFAR2 GPR151 GPR152 JAGN1 KLRC1 LAPTM4B LNPEP MARCHF5 MTIF3 PEX10 PGAP2 RHBDD1 SCAMP4 SLC30A3 SLC30A8 SUSD3 TMEM140 TMEM187 TMEM31 TMEM97 TPRG1 UBE2U YIPF6 ZFPL1
Entrez ID		5192	10668
HPRD ID		04175	09366
Ensembl ID		ENSG00000157911	ENSG00000100532
Uniprot IDs		D6RA89 O60683	Q99675
PDB IDs			2EA5
Enriched GO Terms of Interacting Partners?		Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Import Into Peroxisome Matrix Peroxisomal Membrane Pexophagy Peroxisome Membrane Targeting Sequence Binding Receptor Recycling Intracellular Protein Transmembrane Transport Peroxisome Receptor Metabolic Process Protein Monoubiquitination Protein Import Into Peroxisome Membrane Protein Transmembrane Transport Intracellular Protein Transport Protein Carrier Chaperone Lipid Catabolic Process Cellular Response To Reactive Oxygen Species Establishment Of Protein Localization To Organelle Protein Modification By Small Protein Conjugation Intracellular Transport Catabolic Process Protein-containing Complex Disassembly Post-translational Protein Modification Protein Transmembrane Transporter Activity Macroautophagy Response To Reactive Oxygen Species Very Long-chain Fatty Acid Metabolic Process Cellular Localization Establishment Of Localization In Cell Protein Targeting Cellular Response To Oxidative Stress Protein Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine Establishment Of Integrated Proviral Latency Protein Ubiquitination Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Fatty Acid Beta-oxidation SUMO Conjugating Enzyme Activity Protein Localization To Organelle Cellular Response To Chemical Stress Autophagy Establishment Of Protein Localization Circadian Regulation Of Translation	Membrane Endoplasmic Reticulum Membrane Zinc Ion Import Into Organelle
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