PEX10 and PEX2

Number of citations: 0 (PubMedID 10837480)
Data Source: BioGRID (pull down), HPRD (two hybrid, in vivo)

		PEX10	PEX2
Name		peroxisomal biogenesis factor 10	peroxisomal biogenesis factor 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Membrane	Nucleoplasm Peroxisome Peroxisomal Membrane Cytosol Membrane Cdc73/Paf1 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release	Very Long-chain Fatty Acid Metabolic Process Pexophagy Protein Monoubiquitination Fatty Acid Beta-oxidation Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Protein Destabilization Cellular Response To Reactive Oxygen Species Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Response To Amino Acid Starvation
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import	E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import Class I peroxisomal membrane protein import
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS		Body mass index ( 26426971 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Non-obstructive azoospermia ( 22197933 )	Fasting plasma glucose ( 31170924 ) Height ( 20881960 31562340 ) Infant length ( 25281659 ) Menarche (age at onset) ( 25231870 27182965 ) Nicotine dependence ( 28440896 ) Systolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415 )
Novel Interactors		2 novel interactors: PLCH2 SNX17	2 novel interactors: ELOC PLEKHF2
Interacting Genes		10 interacting genes: CGRRF1 HNRNPD LIG4 MKRN3 PCGF6 PEX12 PEX19 PEX2 PEX5 UBE2I	5 interacting genes: APP ERG28 PEX10 TLE1 USP2-AS1
Entrez ID		5192	5828
HPRD ID		04175	01367
Ensembl ID		ENSG00000157911	ENSG00000164751
Uniprot IDs		D6RA89 O60683	P28328
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Import Into Peroxisome Matrix Peroxisomal Membrane Pexophagy Peroxisome Membrane Targeting Sequence Binding Receptor Recycling Intracellular Protein Transmembrane Transport Peroxisome Receptor Metabolic Process Protein Monoubiquitination Protein Import Into Peroxisome Membrane Protein Transmembrane Transport Intracellular Protein Transport Protein Carrier Chaperone Lipid Catabolic Process Cellular Response To Reactive Oxygen Species Establishment Of Protein Localization To Organelle Protein Modification By Small Protein Conjugation Intracellular Transport Catabolic Process Protein-containing Complex Disassembly Post-translational Protein Modification Protein Transmembrane Transporter Activity Macroautophagy Response To Reactive Oxygen Species Very Long-chain Fatty Acid Metabolic Process Cellular Localization Establishment Of Localization In Cell Protein Targeting Cellular Response To Oxidative Stress Protein Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine Establishment Of Integrated Proviral Latency Protein Ubiquitination Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Fatty Acid Beta-oxidation SUMO Conjugating Enzyme Activity Protein Localization To Organelle Cellular Response To Chemical Stress Autophagy Establishment Of Protein Localization Circadian Regulation Of Translation	Acetylcholine Receptor Activator Activity Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Negative Regulation Of Wnt Signaling Pathway Regulation Of Response To Calcium Ion Axon Midline Choice Point Recognition Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Cellular Response To Norepinephrine Stimulus Lipoprotein Particle Growth Factor Receptor Binding Main Axon Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Astrocyte Activation Involved In Immune Response Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Low-density Lipoprotein Particle Mediated Signaling Target-directed MiRNA Degradation Elongin Complex Transport Vesicle Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Protein Import Into Peroxisome Matrix, Substrate Release Axon Choice Point Recognition Early Endosome Membrane