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PEX10 and PEX12
Number of citations of the paper that reports this interaction (PubMedID
10562279
)
74
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid, in vitro, in vivo)
PEX10
PEX12
Description
peroxisomal biogenesis factor 10
peroxisomal biogenesis factor 12
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Peroxisome
Peroxisomal Membrane
Membrane
Peroxisome
Peroxisomal Membrane
Cytosol
Membrane
Peroxisomal Importomer Complex
Molecular Function
Protein Binding
Zinc Ion Binding
Protein Transmembrane Transporter Activity
Transferase Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
Protein Transmembrane Transporter Activity
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Ubiquitin Ligase Activator Activity
Biological Process
Protein Polyubiquitination
Pexophagy
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Peroxisome Organization
Protein Transport
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Ubiquitination
Cellular Response To Reactive Oxygen Species
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Unfolding
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Polyubiquitination
Pexophagy
Protein Monoubiquitination
Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins
Protein Targeting To Peroxisome
Peroxisome Organization
Protein Transport
Protein Import Into Peroxisome Matrix
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Ubiquitination
Cellular Response To Reactive Oxygen Species
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Protein Unfolding
Protein Import Into Peroxisome Matrix, Substrate Release
Pathways
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import
Peroxisomal protein import
E3 ubiquitin ligases ubiquitinate target proteins
Peroxisomal protein import
Peroxisomal protein import
Class I peroxisomal membrane protein import
Drugs
Diseases
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)
GWAS
Body mass index (
26426971
)
Liver enzyme levels (alkaline phosphatase) (
33972514
)
Non-obstructive azoospermia (
22197933
)
High light scatter reticulocyte count (
32888494
)
High light scatter reticulocyte percentage of red cells (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Red cell distribution width (
27863252
28957414
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Interacting Genes
10 interacting genes:
CGRRF1
HNRNPD
LIG4
MKRN3
PCGF6
PEX12
PEX19
PEX2
PEX5
UBE2I
36 interacting genes:
ACSL5
ADIPOQ
BNIP2
BTN2A2
C5orf46
CLDN10
COL8A2
CXCL16
CYBC1
DNAJC30
ERMP1
FA2H
FKBP8
FXYD6
GJB2
IER3IP1
MARCHF2
MGLL
NKG7
NRM
PEX10
PEX19
PEX5
PNLIPRP1
PTPN9
RBFA
SEC22A
SEC61G
SMCO4
SRGN
STX8
THSD7B
TMEM11
TMEM222
TREX1
TTPA
Entrez ID
5192
5193
HPRD ID
04175
03455
Ensembl ID
ENSG00000157911
ENSG00000108733
Uniprot IDs
D6RA89
O60683
O00623
PDB IDs
Enriched GO Terms of Interacting Partners
?
Peroxisomal Membrane Transport
Establishment Of Protein Localization To Peroxisome
Peroxisome Organization
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Targeting To Peroxisome
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Unfolding
Protein Import Into Peroxisome Matrix
Peroxisomal Membrane
Pexophagy
Peroxisome Membrane Targeting Sequence Binding
Receptor Recycling
Intracellular Protein Transmembrane Transport
Peroxisome
Receptor Metabolic Process
Protein Monoubiquitination
Protein Import Into Peroxisome Membrane
Protein Transmembrane Transport
Intracellular Protein Transport
Protein Carrier Chaperone
Lipid Catabolic Process
Cellular Response To Reactive Oxygen Species
Establishment Of Protein Localization To Organelle
Protein Modification By Small Protein Conjugation
Intracellular Transport
Catabolic Process
Protein-containing Complex Disassembly
Post-translational Protein Modification
Protein Transmembrane Transporter Activity
Macroautophagy
Response To Reactive Oxygen Species
Very Long-chain Fatty Acid Metabolic Process
Cellular Localization
Establishment Of Localization In Cell
Protein Targeting
Cellular Response To Oxidative Stress
Protein Transport
Hepatocyte Dedifferentiation
Cellular Response To Putrescine
Establishment Of Integrated Proviral Latency
Protein Ubiquitination
Negative Regulation Of Lipid Binding
Peroxisome Membrane Class-1 Targeting Sequence Binding
Fatty Acid Beta-oxidation
SUMO Conjugating Enzyme Activity
Protein Localization To Organelle
Cellular Response To Chemical Stress
Autophagy
Establishment Of Protein Localization
Circadian Regulation Of Translation
Peroxisomal Membrane Transport
Establishment Of Protein Localization To Peroxisome
Peroxisome Membrane Targeting Sequence Binding
Endoplasmic Reticulum Membrane
Membrane
Peroxisome Organization
Intracellular Protein Transmembrane Transport
Fatty Acid Metabolic Process
Endoplasmic Reticulum
Protein Import Into Peroxisome Matrix, Substrate Release
Protein Import Into Peroxisome Membrane
Protein Import Into Peroxisome Matrix, Receptor Recycling
Protein Targeting To Peroxisome
Protein Carrier Chaperone
Cytolytic Granule
Granzyme-mediated Programmed Cell Death Signaling Pathway
Protein Unfolding
Peroxisomal Membrane
Protein Import Into Peroxisome Matrix
Monocarboxylic Acid Metabolic Process
Protein Transmembrane Transport
Pexophagy
Triglyceride Catabolic Process
Response To Oxidative Stress
Cellular Response To Oxidative Stress
Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target
Protein Transmembrane Transporter Activity
Receptor Recycling
Cellular Response To Reactive Oxygen Species
Fatty Acid Biosynthetic Process
Acylglycerol Catabolic Process
Lipid Catabolic Process
Maintenance Of Granzyme B Location In T Cell Secretory Granule
Maintenance Of Protease Location In Mast Cell Secretory Granule
T Cell Secretory Granule Organization
Negative Regulation Of Lipid Binding
Peroxisome Membrane Class-1 Targeting Sequence Binding
Membrane Organization
Negative Regulation Of Establishment Of Blood-brain Barrier
Negative Regulation Of Metanephric Mesenchymal Cell Migration
Positive Regulation Of Renal Albumin Absorption
Positive Regulation Of Metanephric Podocyte Development
Positive Regulation Of Glycogen (starch) Synthase Activity
Immune Complex Formation
Adenyl Deoxyribonucleotide Binding
Immune Response In Brain Or Nervous System
Ssh1 Translocon Complex
4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity
Free Fatty Acid 2-hydroxylase Activity
Fatty Acid 2-hydroxylase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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