PEX10 and SNX17

Data Source: HiPPIP (Novel)

		PEX10	SNX17
Name		peroxisomal biogenesis factor 10	sorting nexin 17
Structure		No pdb structure
GO Annotations	Cellular Component	Peroxisome Peroxisomal Membrane Membrane	Cytoplasm Endosome Early Endosome Golgi Apparatus Cytosol Endosome Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Protein-containing Complex
	Molecular Function	Protein Binding Zinc Ion Binding Protein Transmembrane Transporter Activity Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity	Signaling Receptor Binding Protein Binding Lipid Binding Phosphatidylinositol Binding Low-density Lipoprotein Particle Receptor Binding
	Biological Process	Protein Polyubiquitination Pexophagy Protein Monoubiquitination Protein Quality Control For Misfolded Or Incompletely Synthesized Proteins Peroxisome Organization Protein Transport Protein Import Into Peroxisome Matrix Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Ubiquitination Cellular Response To Reactive Oxygen Species Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Unfolding Protein Import Into Peroxisome Matrix, Substrate Release	Kidney Development Cardiac Septum Development Cholesterol Catabolic Process Intracellular Protein Transport Receptor-mediated Endocytosis Signal Transduction Protein Transport Vesicle-mediated Transport Endosomal Transport Regulation Of Endocytosis Endocytic Recycling Aorta Development Coronary Vasculature Development
Pathways		E3 ubiquitin ligases ubiquitinate target proteins Peroxisomal protein import Peroxisomal protein import	None
Diseases		Zellweger syndrome spectrum, including: Zellweger syndrome (ZS); Adrenoleukodystrophy, neonatal (NALD); Infantile Refsum disease (IRD)	None
GWAS		Body mass index ( 26426971 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Non-obstructive azoospermia ( 22197933 )	Alcohol use disorder (total score) ( 30336701 ) Crohn's disease ( 28067908 ) High light scatter reticulocyte count ( 27863252 ) Inflammatory bowel disease ( 28067908 ) LDL cholesterol levels in current drinkers ( 30698716 ) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Microalbuminuria ( 31511532 ) Non-oily fish consumption ( 32066663 ) Refractive error ( 32231278 ) Reticulocyte count ( 27863252 ) Reticulocyte fraction of red cells ( 27863252 ) Serum alkaline phosphatase levels ( 33339817 ) Triglyceride levels ( 34074324 32902719 32203549 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 30910378 31511532 31630189 32600054 ) Urinary sodium to potassium ratio ( 30910378 )
Novel Interactors		2 novel interactors: PLCH2 SNX17	3 novel interactors: KCNG3 PEX10 RHOB
Interacting Genes		10 interacting genes: CGRRF1 HNRNPD LIG4 MKRN3 PCGF6 PEX12 PEX19 PEX2 PEX5 UBE2I	16 interacting genes: ACE2 ANXA2 APP HOXC8 HRAS LDLR LRP1 LRP2 LRP8 RABAC1 RIN1 RLIM RNF128 SELP SKIL VLDLR
Entrez ID		5192	9784
HPRD ID		04175	05812
Ensembl ID		ENSG00000157911	ENSG00000115234
Uniprot IDs		D6RA89 O60683	B4DDM3 B4DQ37 B4DTB8 Q15036
PDB IDs		Not available	3FOG 3LUI 4GXB 4TKN 7RM8 9AU7
GO Terms Enriched among Interactors		Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Peroxisome Organization Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Unfolding Protein Import Into Peroxisome Matrix Peroxisomal Membrane Pexophagy Peroxisome Membrane Targeting Sequence Binding Receptor Recycling Intracellular Protein Transmembrane Transport Peroxisome Receptor Metabolic Process Protein Monoubiquitination Protein Import Into Peroxisome Membrane Protein Transmembrane Transport Intracellular Protein Transport Protein Carrier Chaperone Lipid Catabolic Process Cellular Response To Reactive Oxygen Species Establishment Of Protein Localization To Organelle Protein Modification By Small Protein Conjugation Intracellular Transport Catabolic Process Protein-containing Complex Disassembly Post-translational Protein Modification Protein Transmembrane Transporter Activity Macroautophagy Response To Reactive Oxygen Species Very Long-chain Fatty Acid Metabolic Process Cellular Localization Establishment Of Localization In Cell Protein Targeting Cellular Response To Oxidative Stress Protein Transport Hepatocyte Dedifferentiation Cellular Response To Putrescine Establishment Of Integrated Proviral Latency Protein Ubiquitination Negative Regulation Of Lipid Binding Peroxisome Membrane Class-1 Targeting Sequence Binding Fatty Acid Beta-oxidation SUMO Conjugating Enzyme Activity Protein Localization To Organelle Cellular Response To Chemical Stress Autophagy Establishment Of Protein Localization Circadian Regulation Of Translation	Low-density Lipoprotein Particle Receptor Activity Positive Regulation Of Protein Catabolic Process In The Vacuole Endocytosis Apolipoprotein Binding Very-low-density Lipoprotein Particle Receptor Activity Import Into Cell Clathrin-coated Pit Positive Regulation Of Lysosomal Protein Catabolic Process Cargo Receptor Activity Receptor Complex Vesicle-mediated Transport Regulation Of Lysosomal Protein Catabolic Process Retinoid Metabolic Process Receptor-mediated Endocytosis Reelin Receptor Activity Diterpenoid Metabolic Process Calcium-dependent Protein Binding Regulation Of Protein Catabolic Process Calcium Ion Binding Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Protein Catabolic Process Terpenoid Metabolic Process Amyloid-beta Clearance Isoprenoid Metabolic Process Astrocyte Activation Involved In Immune Response Anatomical Structure Morphogenesis Regulation Of Multicellular Organismal Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Early Endosome Plasma Membrane Amyloid-beta Clearance By Cellular Catabolic Process Ventral Spinal Cord Development Regulation Of Neurogenesis Artery Morphogenesis Clathrin Heavy Chain Binding Reelin-mediated Signaling Pathway Regulation Of Nervous System Development Membrane Plasma Membrane Protein Complex Low-density Lipoprotein Particle Amyloid-beta Binding Positive Regulation Of Dendrite Development Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Heparan Sulfate Proteoglycan Binding Regulation Of Amyloid Fibril Formation Astrocyte Activation Neuron Projection Morphogenesis Regulation Of Low-density Lipoprotein Particle Clearance