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KHDRBS1 and CBL
Number of citations of the paper that reports this interaction (PMID
9045636
)
17
Data Source:
HPRD
(in vivo)
KHDRBS1
CBL
Gene Name
KH domain containing, RNA binding, signal transduction associated 1
Cbl proto-oncogene, E3 ubiquitin protein ligase
Image
Gene Ontology Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Membrane
Grb2-Sos Complex
Nucleus
Cytoplasm
Cytosol
Plasma Membrane
Flotillin Complex
Molecular Function
DNA Binding
RNA Binding
SH3/SH2 Adaptor Activity
Protein Binding
Poly(A) Binding
Poly(U) RNA Binding
SH3 Domain Binding
Protein Complex Binding
Identical Protein Binding
Poly(A) RNA Binding
Phosphotyrosine Binding
Sequence-specific DNA Binding Transcription Factor Activity
Ubiquitin-protein Transferase Activity
Signal Transducer Activity
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Ligase Activity
SH3 Domain Binding
Ephrin Receptor Binding
Biological Process
G2/M Transition Of Mitotic Cell Cycle
Transcription, DNA-templated
MRNA Processing
Cell Cycle Arrest
Signal Transduction
Cell Surface Receptor Signaling Pathway
Cell Proliferation
Positive Regulation Of Signal Transduction
Regulation Of Protein Stability
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Translational Initiation
Regulation Of RNA Export From Nucleus
Positive Regulation Of RNA Export From Nucleus
Regulation Of Transcription, DNA-templated
Cell Surface Receptor Signaling Pathway
Epidermal Growth Factor Receptor Signaling Pathway
Transforming Growth Factor Beta Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Protein Ubiquitination
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of Receptor-mediated Endocytosis
Pathways
Signaling by the B Cell Receptor (BCR)
Loss of Function of TGFBR2 in Cancer
Signaling by FGFR in disease
SMAD2/3 MH2 Domain Mutants in Cancer
Interleukin-6 signaling
TGF-beta receptor signaling activates SMADs
TGFBR1 LBD Mutants in Cancer
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Regulation of KIT signaling
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
Regulation of signaling by CBL
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Negative regulation of FGFR signaling
EGFR downregulation
TGFBR2 MSI Frameshift Mutants in Cancer
SMAD2/3 Phosphorylation Motif Mutants in Cancer
Loss of Function of SMAD2/3 in Cancer
TGFBR2 Kinase Domain Mutants in Cancer
Loss of Function of SMAD4 in Cancer
TGFBR1 KD Mutants in Cancer
Cytokine Signaling in Immune system
Signaling by Ligand-Responsive EGFR Variants in Cancer
Spry regulation of FGF signaling
Signaling by Overexpressed Wild-Type EGFR in Cancer
Loss of Function of TGFBR1 in Cancer
Signaling by FGFR
Signaling by EGFR
Signaling by Interleukins
Signaling by TGF-beta Receptor Complex
Signaling by TGF-beta Receptor Complex in Cancer
Signaling by EGFR in Cancer
Constitutive Signaling by EGFRvIII
Interleukin-3, 5 and GM-CSF signaling
SMAD4 MH2 Domain Mutants in Cancer
Adaptive Immune System
Drugs
Diseases
GWAS
Platelet counts (
22139419
)
Protein-Protein Interactions
109 interactors:
ABI2
ACTB
AGO1
AHI1
AMPH
APBB1
ARHGEF4
ARHGEF9
AZIN1
BAIAP2L1
BTK
BZRAP1
CBL
CD2AP
CDK1
CIRBP
CREB3L3
CREBBP
CRK
CRKL
CSK
DDX5
DHX9
DLG1
DLG2
DLG3
DLG4
DNMBP
DOCK2
DOCK3
EFEMP1
EMG1
FGR
FNBP4
FRK
FYN
GAS7
GPHN
GRAP
GRAP2
GRB2
HCK
HNRNPK
INSR
ITK
ITSN1
ITSN2
JAK3
KHDRBS3
LCK
LYN
MAPK1
MIA2
MPP6
MYO1C
MYO7A
NCF1
NCK1
NCK2
NCKIPSD
NPHP1
OSTF1
PACSIN1
PIK3R1
PIK3R3
PLCG1
PLCG2
POT1
PPP1R13B
PRMT1
PSTPIP1
PTBP2
PTK6
PTPN6
RALY
RAPSN
RASA1
RBFOX2
RBM7
RBMX
RUSC2
SASH1
SCG5
SH3PXD2A
SH3YL1
SKAP2
SMAD2
SMARCA2
SNX30
SNX9
SORBS1
SPATA13
SRC
SSFA2
STAT3
STUB1
TBL1X
TJP1
TNFSF11
TUBB3
U2AF2
UBA52
UBASH3B
VAV1
WBP4
YES1
YTHDC1
ZBTB7A
ZDHHC6
114 interactors:
ABL1
ASAP1
AXL
BCR
BLK
BLNK
BTK
CAPN1
CD19
CD2AP
CD38
CD40
CD5
CDKL2
CRK
CRKL
CSF1R
CTNNB1
CUBN
EGFR
EIF5B
EPHA2
EPHB6
EPOR
ERBB2
F2RL1
FGR
FLOT1
FLT3
FNBP1
FRS2
FYB
FYN
GIF
GRB2
HCK
IGF1R
INPPL1
INSR
ITCH
ITK
ITSN2
KDR
KHDRBS1
KIT
KRT18
LAT
LAT2
LCK
LCP2
LRIG1
LTK
LYN
MAPK8
MET
MYH9
MYO1C
NCK1
NOTCH1
OSTF1
PDGFRA
PDGFRB
PIK3R1
PIK3R2
PLCG1
PRKCA
PRKCQ
PTK2B
PTPN11
PTPN22
PTPN6
RET
SCN5A
SH2B2
SH3KBP1
SHC1
SLA
SLA2
SORBS1
SORBS2
SPRY2
SRC
STAP2
STAT5A
STAT5B
SYK
TCN1
TCN2
TGFBR2
TNFRSF11A
TNS4
TRAF4
TRAF6
TRIM8
TYK2
UBASH3A
UBASH3B
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2G1
UBE2G2
UBE2L3
UBE2M
USP21
VAV1
VAV2
YES1
YWHAB
YWHAG
YWHAQ
YWHAZ
ZAP70
Entrez ID
10657
867
HPRD ID
03926
01320
Ensembl ID
ENSG00000121774
ENSG00000110395
Uniprot IDs
Q07666
P22681
PDB IDs
2XA6
3QHE
1B47
1FBV
1YVH
2CBL
2JUJ
2K4D
2OO9
2Y1M
2Y1N
3BUM
3BUN
3BUO
3BUW
3BUX
3OB1
3OB2
3PLF
4A49
4A4B
4A4C
4GPL
Enriched GO Terms of Interacting Partners
?
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Fc Receptor Signaling Pathway
Signaling
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Cell Communication
Peptidyl-tyrosine Autophosphorylation
Innate Immune Response
Signal Transduction
Immune Response-regulating Signaling Pathway
Immune Response
Endocytosis
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Locomotion
Movement Of Cell Or Subcellular Component
Cellular Response To Stimulus
Positive Regulation Of Metabolic Process
Cell Surface Receptor Signaling Pathway
Defense Response
Positive Regulation Of Immune Response
Regulation Of Immune System Process
Cellular Response To Peptide Hormone Stimulus
Neurotrophin TRK Receptor Signaling Pathway
Phagocytosis
Cellular Response To Peptide
Positive Regulation Of Immune System Process
Neurotrophin Signaling Pathway
Positive Regulation Of Signal Transduction
Cellular Response To Growth Factor Stimulus
Regulation Of Immune Response
Epidermal Growth Factor Receptor Signaling Pathway
Vascular Endothelial Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Response To Growth Factor
Antigen Receptor-mediated Signaling Pathway
Cell Differentiation
Regulation Of Catalytic Activity
Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Regulation Of Cellular Component Organization
Immune System Process
Response To Stimulus
Regulation Of Signaling
Cell Projection Organization
Intracellular Signal Transduction
Cellular Response To Organic Substance
Regulation Of Metabolic Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Immune Response-regulating Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Regulation Of Immune System Process
Immune System Process
Regulation Of Immune Response
Cell Surface Receptor Signaling Pathway
Innate Immune Response
Immune Response
Fc Receptor Signaling Pathway
Positive Regulation Of Signal Transduction
Peptidyl-tyrosine Phosphorylation
Defense Response
Positive Regulation Of Immune System Process
Immune Response-activating Cell Surface Receptor Signaling Pathway
Signal Transduction
Regulation Of Signal Transduction
Positive Regulation Of Immune Response
Regulation Of Signaling
Signaling
Cell Communication
Response To Organic Substance
Cellular Response To Organic Substance
Cell Activation
Antigen Receptor-mediated Signaling Pathway
Intracellular Signal Transduction
Response To Growth Factor
Regulation Of Cell Activation
Cellular Response To Stimulus
Protein Autophosphorylation
Cellular Response To Growth Factor Stimulus
Peptidyl-tyrosine Autophosphorylation
Fc-epsilon Receptor Signaling Pathway
Positive Regulation Of Intracellular Signal Transduction
Cell Migration
Locomotion
Regulation Of Intracellular Signal Transduction
Cell Motility
Regulation Of MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Lymphocyte Activation
Positive Regulation Of MAPK Cascade
Regulation Of Phosphorylation
Neurotrophin TRK Receptor Signaling Pathway
Response To Stimulus
Movement Of Cell Or Subcellular Component
Wound Healing
Tagcloud
?
32dcl3
32p
antisera
eliminated
engagement
fusion
fyn
gst
hck
immunoprecipitated
immunoprecipitates
implying
lyn
lysate
lzip
nb2
nonphosphorylated
p85
phosphatidylinositol
phosphorylate
phosphoserine
phosphothreonine
phosphotyrosine
proline
sh2
sh3
thymoma
tyr731
yeam
Tagcloud (Difference)
?
32dcl3
32p
antisera
eliminated
engagement
fusion
fyn
gst
hck
immunoprecipitated
immunoprecipitates
implying
lyn
lysate
lzip
nb2
nonphosphorylated
p85
phosphatidylinositol
phosphorylate
phosphoserine
phosphothreonine
phosphotyrosine
proline
sh2
sh3
thymoma
tyr731
yeam
Tagcloud (Intersection)
?