KHDRBS1 and FRK

Number of citations of the paper that reports this interaction (PMID 22745667)
1

Data Source:
BioGRID (unspecified method)

		KHDRBS1	FRK
Gene Name		KH domain containing, RNA binding, signal transduction associated 1	fyn-related Src family tyrosine kinase
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Grb2-Sos Complex	Intracellular Nucleus Cytoplasm Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	DNA Binding RNA Binding SH3/SH2 Adaptor Activity Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Complex Binding Identical Protein Binding Poly(A) RNA Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Protein Binding ATP Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Transcription, DNA-templated MRNA Processing Cell Cycle Arrest Signal Transduction Cell Surface Receptor Signaling Pathway Cell Proliferation Positive Regulation Of Signal Transduction Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus	Protein Phosphorylation Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Migration Actin Cytoskeleton Organization Cell Differentiation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Proliferation Innate Immune Response
Pathways
Drugs
Diseases
GWAS			Age-related macular degeneration ( 21665990) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Urate levels ( 23263486)
Protein-Protein Interactions		109 interactors: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK BZRAP1 CBL CD2AP CDK1 CIRBP CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MIA2 MPP6 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SSFA2 STAT3 STUB1 TBL1X TJP1 TNFSF11 TUBB3 U2AF2 UBA52 UBASH3B VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	4 interactors: BNIP2 KHDRBS1 RB1 SF3B4
Entrez ID		10657	2444
HPRD ID		03926	05954
Ensembl ID		ENSG00000121774
Uniprot IDs		Q07666	P42685
PDB IDs		2XA6 3QHE
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Communication Peptidyl-tyrosine Autophosphorylation Innate Immune Response Signal Transduction Immune Response-regulating Signaling Pathway Immune Response Endocytosis Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Locomotion Movement Of Cell Or Subcellular Component Cellular Response To Stimulus Positive Regulation Of Metabolic Process Cell Surface Receptor Signaling Pathway Defense Response Positive Regulation Of Immune Response Regulation Of Immune System Process Cellular Response To Peptide Hormone Stimulus Neurotrophin TRK Receptor Signaling Pathway Phagocytosis Cellular Response To Peptide Positive Regulation Of Immune System Process Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus Regulation Of Immune Response Epidermal Growth Factor Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Response To Growth Factor Antigen Receptor-mediated Signaling Pathway Cell Differentiation Regulation Of Catalytic Activity Regulation Of Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Component Organization Immune System Process Response To Stimulus Regulation Of Signaling Cell Projection Organization Intracellular Signal Transduction Cellular Response To Organic Substance Regulation Of Metabolic Process	Positive Regulation Of Cellular Metabolic Process Cell Cycle Arrest Positive Regulation Of RNA Export From Nucleus Negative Regulation Of Transcription From RNA Polymerase II Promoter During Mitosis Sister Chromatid Biorientation Positive Regulation Of Metabolic Process Regulation Of Centromere Complex Assembly Negative Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Striated Muscle Cell Differentiation Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Cohesin Localization To Chromatin Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Muscle Cell Differentiation Positive Regulation Of Mitotic Metaphase/anaphase Transition Glial Cell Apoptotic Process Protein Localization To Chromosome, Centromeric Region Attachment Of Spindle Microtubules To Kinetochore MRNA Processing Positive Regulation Of Macrophage Differentiation Microtubule Cytoskeleton Organization Regulation Of RNA Export From Nucleus Negative Regulation Of Cell Cycle Positive Regulation Of Translational Initiation Mitotic Sister Chromatid Cohesion Enucleate Erythrocyte Differentiation Positive Regulation Of Chromosome Segregation Muscle Structure Development Regulation Of Sister Chromatid Cohesion MRNA Metabolic Process Hepatocyte Apoptotic Process RNA Processing Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of MRNA Splicing, Via Spliceosome Mitotic Metaphase Plate Congression Mitotic Cell Cycle Process Protein Localization To Chromosome Neuron Maturation Sister Chromatid Cohesion Metaphase Plate Congression Negative Regulation Of Smoothened Signaling Pathway Mitotic Cell Cycle Positive Regulation Of RNA Splicing Regulation Of Signal Transduction Microtubule-based Process Androgen Receptor Signaling Pathway Positive Regulation Of Mitotic Nuclear Division Establishment Of Chromosome Localization
Tagcloud ?			accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma sirna src suppressing suppressive
Tagcloud (Difference) ?			accompanied accumulation alters arrest consequent disclosed distinctive e2f1 fyn g1 glioma hyperphosphorylated importantly inhibiting investigation member noteworthy nucleus prb proliferating proliferative promoted proper protective retinoblastoma sirna src suppressing suppressive
Tagcloud (Intersection) ?