KHDRBS1 and DNMBP

Number of citations of the paper that reports this interaction (PubMedID 22745667)
76

Data Source:
BioGRID (unspecified method)

		KHDRBS1	DNMBP
Description		KH RNA binding domain containing, signal transduction associated 1	dynamin binding protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Nucleoplasm Nucleolus Cytoplasm Golgi Apparatus Golgi Stack Cytosol Cytoskeleton Cell-cell Junction Nuclear Body Synapse Anchoring Junction Presynapse
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity Protein Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Surface Receptor Signaling Pathway Spermatogenesis Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Regulation Of Cell Cycle	Regulation Of Cell Shape Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Cilium Assembly
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	CDC42 GTPase cycle
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Stent thrombosis in response to clopidogrel treatment ( 32472697)
Interacting Genes		116 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CEBPA CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 DSCAM EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC USP7 VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	21 interacting genes: ACTA1 ARHGAP17 BUB1B CDC42 CNN1 CYFIP2 DBN1 DNM1 ENAH EVL FASLG HSPA1B KHDRBS1 NCKAP1 RAC1 RAPH1 UBC VASP WASF1 WASL WIPF2
Entrez ID		10657	23268
HPRD ID		03926	10918
Ensembl ID		ENSG00000121774	ENSG00000107554
Uniprot IDs		Q07666	A0A1B0GTX1 A0A1C7CYY6 B3KY33 Q6XZF7
PDB IDs		2XA6 3QHE 7Z89 7Z8A 7Z9A 7Z9B 7ZAB 7ZAC 7ZAF 7ZAM	1UG1 1UHC 4CC2 4CC3 4CC4 4CC7 4GLM
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Cytoplasm Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell-cell Junction Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway SH3 Domain Binding Protein Binding Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction T Cell Receptor Signaling Pathway T Cell Costimulation Regulation Of Endocytosis Fc-gamma Receptor Signaling Pathway Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphorylation Regulation Of Transport Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Developmental Process Regulation Of Immune Response Immune System Process Ionotropic Glutamate Receptor Binding Endocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ephrin Receptor Signaling Pathway	Actin Filament Organization Lamellipodium Cytoskeleton Actin Polymerization Or Depolymerization Supramolecular Fiber Organization Profilin Binding Focal Adhesion Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Cytoskeleton Organization Actin Binding Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Filopodium Neuron Projection Development Positive Regulation Of Protein Polymerization Actin Cytoskeleton Organization SH3 Domain Binding Positive Regulation Of Cellular Component Organization Postsynapse SCAR Complex Positive Regulation Of Actin Filament Polymerization Regulation Of Actin Filament Polymerization Actin Filament-based Process Plasma Membrane Bounded Cell Projection Organization Regulation Of Organelle Organization Regulation Of Cellular Component Size Regulation Of Protein-containing Complex Assembly Regulation Of Postsynapse Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Cellular Component Organization Regulation Of Actin Filament Length Actin Cytoskeleton Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Cell Projection Organization Cytoplasm Rac Protein Signal Transduction Positive Regulation Of Protein-containing Complex Assembly Cytosol Positive Regulation Of Lamellipodium Assembly Axon Guidance Neuron Projection Guidance Cell Projection Regulation Of Cell Projection Assembly Actin Filament Polymerization Extracellular Exosome Positive Regulation Of Lamellipodium Organization
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