KHDRBS1 and YTHDC1

Number of citations of the paper that reports this interaction (PubMedID 10564280)
80

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		KHDRBS1	YTHDC1
Description		KH RNA binding domain containing, signal transduction associated 1	YTH N6-methyladenosine RNA binding protein C1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Nucleus Nucleoplasm Plasma Membrane Nuclear Speck
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity Protein Tyrosine Kinase Binding	RNA Binding MRNA Binding Protein Binding N6-methyladenosine-containing RNA Reader Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Surface Receptor Signaling Pathway Spermatogenesis Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Regulation Of Cell Cycle	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome In Utero Embryonic Development MRNA Splice Site Recognition MRNA Processing MRNA Export From Nucleus Spermatogenesis RNA Splicing Dosage Compensation By Inactivation Of X Chromosome Post-transcriptional Regulation Of Gene Expression Regulation Of MRNA Splicing, Via Spliceosome Primary Follicle Stage MRNA Alternative Polyadenylation
Pathways		PTK6 Regulates Proteins Involved in RNA Processing	Nuclear RNA decay
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Mean corpuscular hemoglobin ( 32888494) Obesity-related traits ( 23251661)
Interacting Genes		116 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CEBPA CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 DSCAM EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC USP7 VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	41 interacting genes: ABL1 ADAMTS4 ANKRD28 CFH CLK1 CLK2 CORO1A DVL3 EDC4 EMD FYN GOLGA2 HNRNPK KHDRBS1 KHDRBS2 KHDRBS3 KRT18 KRTAP10-6 LAMC3 LAMTOR5 LZTS2 PHF19 PICK1 PLG PROSER2 RBMY1A1 RBMY1F RBMY1J RNPS1 SDCBP2 SEPTIN10 SOX13 SRC SRPK1 SRPK2 SRSF1 SRSF2 TRA2A TRA2B TXK VPS51
Entrez ID		10657	91746
HPRD ID		03926	11689
Ensembl ID		ENSG00000121774	ENSG00000083896
Uniprot IDs		Q07666	J3QR07 Q96MU7
PDB IDs		2XA6 3QHE 7Z89 7Z8A 7Z9A 7Z9B 7ZAB 7ZAC 7ZAF 7ZAM	2YUD 4R3H 4R3I 6RT4 6RT5 6RT6 6RT7 6SYZ 6SZ1 6SZ2 6SZ3 6SZL 6SZN 6SZR 6SZT 6SZX 6SZY 6T01 6T02 6T03 6T04 6T05 6T06 6T07 6T08 6T09 6T0A 6T0C 6T0D 6T0O 6T0X 6T0Z 6T10 6T11 6T12 6WE8 6WE9 6WEA 6YKE 6YKI 6YKJ 6YKZ 6YL0 6YL8 6YL9 6YM2 6YM8 6YNI 6YNJ 6YNK 6YNL 6YNM 6YNN 6YNO 6YNP 6YOQ 6ZCM 6ZCN 6ZD9 7L4X 7L4Y 7P87 7P88 7P8A 7P8B 7P8F 7PJ7 7PJ8 7PJ9 7PJA 7PJB 7PJP 7PJQ 7PO6 8K2E 8Q2Q 8Q2R 8Q2S 8Q2T 8Q2U 8Q2V 8Q2W 8Q2X 8Q2Y 8Q31 8Q32 8Q33 8Q35 8Q37 8Q38 8Q39 8Q3A 8Q3G 8Q4M 8Q4N 8Q4P 8Q4Q 8Q4R 8Q4T 8Q4U 8Q4V 8Q4W
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Cytoplasm Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell-cell Junction Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway SH3 Domain Binding Protein Binding Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction T Cell Receptor Signaling Pathway T Cell Costimulation Regulation Of Endocytosis Fc-gamma Receptor Signaling Pathway Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphorylation Regulation Of Transport Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Developmental Process Regulation Of Immune Response Immune System Process Ionotropic Glutamate Receptor Binding Endocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ephrin Receptor Signaling Pathway	Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Processing Regulation Of MRNA Metabolic Process MRNA Processing MRNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome RNA Splicing Positive Regulation Of RNA Splicing RNA Processing Nucleic Acid Binding Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Domain Specific Binding Non-membrane Spanning Protein Tyrosine Kinase Activity MRNA Binding RNA Binding Spliceosomal Complex RNA Metabolic Process Protein Tyrosine Kinase Activity Macromolecule Metabolic Process SH2 Domain Binding Nucleoplasm Nuclear Speck Nucleic Acid Metabolic Process Regulation Of Macromolecule Biosynthetic Process Protein Phosphorylation Positive Regulation Of Gene Expression Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Protein Kinase Activity Positive Regulation Of MRNA Metabolic Process Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Gene Expression Phosphorylation Regulation Of RNA Metabolic Process Identical Protein Binding Ephrin Receptor Binding Nucleus Regulation Of Primary Metabolic Process Nucleolus Fc-gamma Receptor Signaling Pathway Kinase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Nucleobase-containing Compound Metabolic Process RNA Splicing, Via Transesterification Reactions Negative Regulation Of Actin Nucleation Activated T Cell Proliferation Ephrin Receptor Signaling Pathway
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