KHDRBS1 and RALY

Number of citations of the paper that reports this interaction (PubMedID 22365833)
0

Data Source:
BioGRID (two hybrid, two hybrid)

		KHDRBS1	RALY
Description		KH RNA binding domain containing, signal transduction associated 1	RALY heterogeneous nuclear ribonucleoprotein
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Molecular Function Inhibitor Activity Protein Tyrosine Kinase Binding	Nucleic Acid Binding Transcription Coregulator Activity RNA Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Cell Surface Receptor Signaling Pathway Spermatogenesis Regulation Of Protein Stability Regulation Of Apoptotic Process Regulation Of RNA Splicing Negative Regulation Of DNA-templated Transcription Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing Cholesterol Homeostasis
Pathways		PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Adult body size ( 32376654) Basal cell carcinoma ( 33549134 27539887 31174203) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 22976474) Cancer ( 27197191) Cancer (pleiotropy) ( 27197191) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 32041948) Estimated glomerular filtration rate ( 31451708) Facial pigmentation ( 25705849) Hair color ( 29662168) HDL cholesterol levels ( 32203549) Hip circumference adjusted for BMI ( 34021172) Idiopathic dilated cardiomyopathy ( 29495422) Keratinocyte cancer (MTAG) ( 31174203) Low tan response ( 29739929) Melanoma ( 28212542) Nevus count or cutaneous melanoma ( 32341527) Non-melanoma skin cancer ( 29739929) Red cell distribution width ( 32888494) Red vs. brown/black hair color ( 30531825) Refractive error ( 32231278) Skin colour saturation ( 25963972) Skin sensitivity to sun ( 25963972) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell carcinoma ( 26829030) Type 2 diabetes ( 30297969) Vitiligo ( 27723757) Weight ( 28552196) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		116 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CEBPA CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 DSCAM EFEMP1 EMG1 FGR FNBP4 FRK FXR1 FXR2 FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OGT OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SHANK3 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC USP7 VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	30 interacting genes: BCCIP BYSL CELF1 EXOC7 GTPBP3 HNRNPD HNRNPH1 HNRNPK HSF2BP KHDRBS1 LNX1 MDM2 MRPL38 MTUS2 PCBP1 PIK3CD PLOD3 PRKN QKI RBPMS2 RPL9 SDCBP SPG7 THAP1 TIGD3 USP7 WDR62 ZBTB24 ZNF408 ZNF76
Entrez ID		10657	22913
HPRD ID		03926	11480
Ensembl ID		ENSG00000121774	ENSG00000125970
Uniprot IDs		Q07666	Q53GL6 Q9UKM9
PDB IDs		2XA6 3QHE 7Z89 7Z8A 7Z9A 7Z9B 7ZAB 7ZAC 7ZAF 7ZAM	1WF1
Enriched GO Terms of Interacting Partners?		Phosphotyrosine Residue Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Cytosol Cytoplasm Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-tyrosine Phosphorylation Cell-cell Junction Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Tyrosine Kinase Activity Immune Response-activating Signaling Pathway Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway SH3 Domain Binding Protein Binding Activation Of Immune Response Regulation Of Intracellular Signal Transduction Antigen Receptor-mediated Signaling Pathway Plasma Membrane Regulation Of Signaling Regulation Of Cell Communication Regulation Of Signal Transduction T Cell Receptor Signaling Pathway T Cell Costimulation Regulation Of Endocytosis Fc-gamma Receptor Signaling Pathway Intracellular Signaling Cassette Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Phosphorylation Regulation Of Transport Protein Phosphorylation Fc Receptor Mediated Stimulatory Signaling Pathway Ephrin Receptor Binding Positive Regulation Of Immune Response Regulation Of Immune System Process Positive Regulation Of Immune System Process Regulation Of Vesicle-mediated Transport Developmental Process Regulation Of Immune Response Immune System Process Ionotropic Glutamate Receptor Binding Endocytosis Negative Regulation Of Inflammatory Response To Antigenic Stimulus Ephrin Receptor Signaling Pathway	Nucleic Acid Binding MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Ribonucleoprotein Complex Regulation Of MRNA Processing Response To Ether Nucleic Acid Metabolic Process RNA Metabolic Process Nucleus Regulation Of MRNA Metabolic Process Cytoplasmic Stress Granule RNA Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Retrograde Transport, Endosome To Golgi RNA Processing Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Regulation Of Telomere Capping Positive Regulation Of Catabolic Process Regulation Of Exosomal Secretion Identical Protein Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Poly(U) RNA Binding Protein Binding Negative Regulation Of MRNA Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Postsynaptic Density Regulation Of Macromolecule Biosynthetic Process MRNA Processing SH3 Domain Binding Positive Regulation Of MRNA Catabolic Process Cytosol Cytoplasm Regulation Of Primary Metabolic Process Amyloid Fibril Formation Regulation Of Intracellular Transport Regulation Of DNA-templated Transcription Regulation Of Macromolecule Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Hepatocyte Dedifferentiation Cellular Response To Putrescine Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Formaldehyde Cellular Response To Vitamin B1
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