IRF3 and SGTA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		IRF3	SGTA
Gene Name		interferon regulatory factor 3	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Cytoplasm
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death	Biological_process Viral Process
Pathways		Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A	92 interactors: ADIPOQ AGR3 BAG6 BCL2L12 C1QA C1QTNF1 C1QTNF6 C3orf52 CARKD CCDC155 CD79B CD99 CDH15 COL1A2 COL8A2 CSF1 CST1 CTSL CXCL8 EFEMP1 EFEMP2 ERP27 EVA1B F11R FERD3L FIP1L1 FKBP7 FXYD7 GABARAPL2 GAL GHR GIP GPX7 GRN GYPA HSP90AA1 HSP90AB1 HSPA13 HSPA8 IGL IGLC1 IRF3 IRF5 ITPRIPL1 KRT6A KTN1 LAIR2 LAT MSMB MSTN MYDGF NME3 NXF1 PBXIP1 PCDHA4 PFN2 PIAS1 PPIB PPIC PPP1R3C PRAP1 PTN RARRES3 RPN1 SDC4 SERPINE1 SGCA SLPI SMAGP SOD3 SPP1 SPPL2A SRGN SYT11 SYT4 TFF3 TFRC TGFA TMEM174 TMEM31 TMPO TMUB2 TNFRSF13B TNFRSF1A TWSG1 TXNDC12 UBL4A UPK3A VIP WBP1L ZG16 ZG16B
Entrez ID		3661	6449
HPRD ID		04769	04568
Ensembl ID		ENSG00000126456	ENSG00000104969
Uniprot IDs		E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653	O43765
PDB IDs		1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6	2VYI 4GOD 4GOE 4GOF
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Response To Stress Protein Heterotrimerization Extracellular Matrix Organization Extracellular Structure Organization Defense Response Regulation Of Immune System Process Protein Trimerization Macrophage Apoptotic Process Response To Wounding Regulation Of Secretion Immune System Process Regulation Of Protein Metabolic Process Anatomical Structure Development Regulation Of Cell Proliferation Protein Heterooligomerization Cell Communication Cell Surface Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Localization Positive Regulation Of Immune System Process Wound Healing Regulation Of Cellular Protein Metabolic Process Signaling Regulation Of Cellular Response To Heat Negative Regulation Of Proteolysis Positive Regulation Of Protein Modification Process Negative Regulation Of Protein Processing Developmental Process Multicellular Organismal Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane Innate Immune Response Cellular Response To Stimulus Regulation Of Cytokine-mediated Signaling Pathway Extracellular Matrix Disassembly Myeloid Cell Apoptotic Process Response To Organic Substance Protein Folding Regulation Of Protein Processing Response To Lipid Regulation Of Developmental Growth Protein Insertion Into ER Membrane Inflammatory Cell Apoptotic Process Positive Regulation Of Cellular Metabolic Process System Development Regulation Of Immune Response Inflammatory Response Signal Transduction Positive Regulation Of Protein Metabolic Process
Tagcloud ?		antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively	bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Difference) ?		antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively	bag6 biochemically biophysical calorimetry compete connecting decided dimerisation glutamine haddock helices hydrophobic isothermal itc microscale mst nt paths perturbation resides solve tetratricopeptide thermophoresis titration tpr trc35 trimeric ubl ubl4a
Tagcloud (Intersection) ?