IRF3 and CREBBP

Number of citations of the paper that reports this interaction (PMID 10521456)
18

Data Source:
HPRD (in vivo, in vitro)

		IRF3	CREBBP
Gene Name		interferon regulatory factor 3	CREB binding protein
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Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Histone Acetyltransferase Complex Nuclear Chromatin Condensed Chromosome Outer Kinetochore Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Body
	Molecular Function	DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Cofactor Activity Protein Binding Identical Protein Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding	Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Transcription Factor Binding RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Coactivator Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription P53 Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Acetyltransferase Activity MRF Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Transcription From RNA Polymerase II Promoter Apoptotic Process Cellular Response To DNA Damage Stimulus Viral Process Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MDA-5 Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Type I Interferon Biosynthetic Process Negative Regulation Of Interferon-beta Biosynthetic Process Negative Regulation Of Defense Response To Virus By Host Positive Regulation Of Cytokine Secretion Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To DsRNA Macrophage Apoptotic Process Programmed Necrotic Cell Death	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Chromatin Organization Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Protein Complex Assembly Signal Transduction Notch Signaling Pathway Regulation Of Smoothened Signaling Pathway Gene Expression Viral Process Histone Acetylation N-terminal Peptidyl-lysine Acetylation Germ-line Stem Cell Maintenance Positive Regulation Of Type I Interferon Production Cellular Response To Heat Homeostatic Process Embryonic Digit Morphogenesis Cellular Lipid Metabolic Process Small Molecule Metabolic Process Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Cellular Response To Hypoxia Regulation Of Cellular Response To Heat
Pathways		Negative regulators of RIG-I/MDA5 signaling Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon Interferon gamma signaling Activated TLR4 signalling TRAF3-dependent IRF activation pathway ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN STING mediated induction of host immune responses Interferon alpha/beta signaling Innate Immune System ISG15 antiviral mechanism TRIF-mediated TLR3/TLR4 signaling Cytosolic sensors of pathogen-associated DNA Interferon Signaling Cytokine Signaling in Immune system MyD88-independent cascade Factors involved in megakaryocyte development and platelet production Antiviral mechanism by IFN-stimulated genes Toll-Like Receptors Cascades RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Regulation of innate immune responses to cytosolic DNA Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production TRAF6 mediated IRF7 activation IRF3-mediated induction of type I IFN	Signaling by NOTCH1 HD Domain Mutants in Cancer Metabolism of lipids and lipoproteins Signaling by Wnt Regulation of gene expression by Hypoxia-inducible Factor Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Generic Transcription Pathway Pre-NOTCH Transcription and Translation RNF mutants show enhanced WNT signaling and proliferation Signaling by NOTCH1 in Cancer Orphan transporters Chromatin organization misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling Signaling by NOTCH formation of the beta-catenin:TCF transactivating complex Factors involved in megakaryocyte development and platelet production Chromatin modifying enzymes LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Signaling by NOTCH1 PEST Domain Mutants in Cancer Activation of gene expression by SREBF (SREBP) Transcriptional activation of mitochondrial biogenesis Constitutive Signaling by NOTCH1 PEST Domain Mutants PPARA activates gene expression Cellular response to hypoxia Organelle biogenesis and maintenance Regulation of Hypoxia-inducible Factor (HIF) by oxygen Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer Attenuation phase HATs acetylate histones RORA activates circadian gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) HSF1-dependent transactivation TRAF3-dependent IRF activation pathway Signaling by NOTCH1 Transcriptional regulation of white adipocyte differentiation XAV939 inhibits tankyrase, stabilizing AXIN Pre-NOTCH Expression and Processing Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Innate Immune System FBXW7 Mutants and NOTCH1 in Cancer Fatty acid, triacylglycerol, and ketone body metabolism Cytosolic sensors of pathogen-associated DNA Cellular response to heat stress REV-ERBA represses gene expression Mitochondrial biogenesis Notch-HLH transcription pathway RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways NOTCH1 Intracellular Domain Regulates Transcription TCF dependent signaling in response to WNT TRAF6 mediated IRF7 activation YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Signaling by WNT in cancer BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS			Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Obesity-related traits ( 23251661) QT interval (interaction) ( 23459443)
Protein-Protein Interactions		25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A	253 interactors: ACTA2 ACVR1 AIRE AKT1 ALX1 ANAPC5 ANAPC7 AP1B1 APC AR ATF1 ATF3 BCL3 BCL6 BRCA1 CALCOCO1 CAMK4 CARM1 CDC25B CDH2 CDK5RAP3 CDX2 CEBPA CEBPB CEBPD CENPJ CHUK CITED1 CITED2 CNOT3 CNTN2 CREB1 CREM CRX CSK CSNK2A1 CSNK2A2 CTBP1 CTNNB1 CUX1 DACH1 DAXX DDX17 DDX5 DEK E2F1 E2F3 E2F5 EBF1 EGR1 EID1 EID3 EIF2B1 ELF3 ELK1 EP300 ESR1 ETS1 ETS2 EWSR1 FGFR1 FHL2 FOS FOXM1 FOXO1 FOXO4 GABPA GAK GATA1 GCM1 GLI3 GMEB1 GMEB2 GTF2B H3F3A HBP1 HCK HDAC1 HDAC3 HIF1A HIPK2 HIST1H2BB HIST1H3A HIST1H4A HIST2H2BE HIST3H3 HIST4H4 HLF HMGA1 HMGB1 HMGB2 HNF1A HNF1B HNF4A HOXA10 HOXA11 HOXA9 HOXB1 HOXB2 HOXB3 HOXB4 HOXB6 HOXB7 HOXB9 HOXD10 HOXD12 HOXD13 HOXD4 HSF1 HTT IKBKG IRF1 IRF3 IRF5 IRF7 JDP2 JUN KAT2A KAT2B KAT5 KAT6A KDM3B KHDRBS1 KLF1 KLF13 KLF4 KLF5 KMT2A KPNA2 KPNA6 LDLR LIG4 LYN MAF MAFG MAML1 MAML2 MAP3K5 MAPK1 MAPK10 MAPK3 MBD2 MDC1 MDM2 MECOM MED25 MGMT MIER1 MKNK1 MSH2 MSH6 MSX1 MYB MYBL1 MYBL2 MYC MYOD1 N4BP2 NAP1L1 NCOA1 NCOA2 NCOA3 NCOA6 NEUROG1 NFATC2 NFATC4 NFE2 NFE2L2 NFIA NFIC NKX2-1 NLK NPAS2 NPAT NR3C1 NR5A1 NUP98 ONECUT1 PARP1 PAX5 PBX1 PCMT1 PELP1 PHOX2A PIAS1 PLAGL1 PML POLR2A POU1F1 POU2F3 PPARG PPARGC1A PRKCD PRLR PROX1 PSME3 PTMA RAD23A RBBP4 RBBP7 RBCK1 RELA RPS6KA1 RPS6KA3 RPS6KA5 RXRG SERTAD1 SERTAD2 SERTAD3 SH3GL1 SMAD2 SMAD3 SMAD4 SND1 SNIP1 SOX9 SPI1 SPIB SRCAP SREBF1 SREBF2 SRF SS18L1 STAT1 STAT2 STAT3 STAT4 STAT6 SUV39H1 TACC2 TAF6L TCF12 TCF3 TDG TFDP1 TGS1 THRA TP53 TP73 TRERF1 TRIP10 TRIP4 UBE2D1 UBE2I UBTF VDR WT1 XAF1 XRCC6 YWHAH ZBTB17 ZBTB2 ZNF639
Entrez ID		3661	1387
HPRD ID		04769	02534
Ensembl ID		ENSG00000126456	ENSG00000005339
Uniprot IDs		E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653	Q92793
PDB IDs		1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6	1JSP 1LIQ 1RDT 1WO3 1WO4 1WO5 1WO6 1WO7 1ZOQ 2D82 2KJE 2KWF 2L84 2L85 2LXS 2LXT 2RNY 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K
Enriched GO Terms of Interacting Partners?		Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Innate Immune Response TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor Signaling Pathway Positive Regulation Of Interferon-beta Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Immune Response Regulation Of Innate Immune Response Defense Response Regulation Of Interferon-beta Production Immune Response-regulating Signaling Pathway Viral Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Immune System Process Positive Regulation Of Interferon-alpha Production Positive Regulation Of Immune Response Positive Regulation Of Immune System Process Defense Response To Virus Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Gene Expression Response To Virus Positive Regulation Of Signal Transduction Regulation Of Immune System Process Regulation Of Gene Expression I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Response To Other Organism Signaling Response To Bacterium Positive Regulation Of Transcription From RNA Polymerase II Promoter Response To Biotic Stimulus Cell Communication Regulation Of Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter	Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription, DNA-templated Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process RNA Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Transcription From RNA Polymerase II Promoter Biosynthetic Process Cellular Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of Biosynthetic Process Regulation Of Cellular Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription From RNA Polymerase II Promoter Developmental Process Organ Development Multicellular Organismal Development System Development Anatomical Structure Development Response To Organic Substance Metabolic Process Cell Differentiation Cellular Response To Organic Substance Regulation Of Cell Differentiation Regulation Of Cell Proliferation Tissue Development Cellular Response To Stress
Tagcloud ?		antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively	adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes
Tagcloud (Difference) ?		antiviral called cif coactivator composed contain creb cytomegalovirus defense establishes foreskin hcmv immediate interacts interferon interferons intrinsic isg54 latent numerous participate possess responsive shortcut stat stat1 stat2 stimulated tentatively	adulthood amp backgroundrubinstein big births broad consuming cooperation costly disabilities discussionrsts dysmorphic ep300 establishing extremely facial highlighted intellectual microcephaly multicenter retardation rsts summarized summarythe survive taybi thumbs toe toes
Tagcloud (Intersection) ?