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IRF3 and UFL1
Number of citations of the paper that reports this interaction (PubMedID
32545848
)
54
Data Source:
BioGRID
(two hybrid)
IRF3
UFL1
Description
interferon regulatory factor 3
UFM1 specific ligase 1
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nucleus
Chromosome
Cytoplasm
Mitochondrial Outer Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Membrane
Protein-containing Complex
Site Of Double-strand Break
Neuron Projection
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Protein Binding
Transferase Activity
Protein Kinase Binding
UFM1 Ligase Activity
UFM1 Transferase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cytokine Production
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
MRNA Transcription
Response To Bacterium
Regulation Of Gene Expression
Programmed Cell Death
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Exogenous DsRNA
Macrophage Apoptotic Process
Programmed Necrotic Cell Death
Cellular Response To Virus
Antiviral Innate Immune Response
CGAS/STING Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
DNA Damage Checkpoint Signaling
Double-strand Break Repair Via Homologous Recombination
DNA Double-strand Break Processing
Osteoblast Differentiation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
DNA Repair
DNA Damage Response
Blood Circulation
Positive Regulation Of Cell Population Proliferation
Regulation Of Gene Expression
Positive Regulation Of Autophagy
Erythrocyte Differentiation
DNA Damage Response, Signal Transduction By P53 Class Mediator
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ribosome Disassembly
Regulation Of Protein Localization
Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Response To Endoplasmic Reticulum Stress
Regulation Of Canonical NF-kappaB Signal Transduction
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
NLRP3 Inflammasome Complex Assembly
Regulation Of Inflammatory Response
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Hematopoietic Stem Cell Differentiation
Positive Regulation Of Glial Cell Proliferation
Reticulophagy
Protein Ufmylation
Rescue Of Stalled Ribosome
Antiviral Innate Immune Response
Positive Regulation Of Reticulophagy
Negative Regulation Of Signal Transduction By P53 Class Mediator
Response To L-glutamate
Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
Negative Regulation Of IRE1-mediated Unfolded Protein Response
Protein K69-linked Ufmylation
Pathways
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Autoimmune thyroid disease (
32581359
)
Schizophrenia (
29483656
)
Vitiligo (
27723757
)
Diastolic blood pressure (
27841878
)
Headache (
29397368
)
Language functional connectivity (
34929384
)
Migraine (
27322543
)
Migraine without aura (
27322543
)
Night sleep phenotypes (
27126917
)
Pulse pressure (
27841878
)
Systolic blood pressure (
27841878
)
Triglyceride levels (
32203549
)
Walking pace (
33128006
)
Interacting Genes
35 interacting genes:
CREBBP
EP300
EWSR1
FBXO7
GRIP1
HERC5
HSP90AA1
IKBKE
ILF3
IRF5
IRF7
JMJD6
MAPK8
MAVS
OGT
PEX19
PIAS4
PPIB
PRDX1
PSMD14
RB1
RBL1
RELA
SERPINB2
SGTA
SMURF2
SYT1
TBK1
TICAM1
TICAM2
TOMM70
TRIM26
TRIM55
TRIM63
UFL1
17 interacting genes:
AHCY
AKAP17A
ATP4A
ENY2
FGB
H2AC4
HINFP
IRAK1BP1
IRF3
MT1M
PPIL1
PTPRO
TIPRL
TP53
TSC22D3
UFC1
ZNF219
Entrez ID
3661
23376
HPRD ID
04769
11109
Ensembl ID
ENSG00000126456
ENSG00000014123
Uniprot IDs
E2GIM5
E2GIM6
E2GIM7
E2GIM8
E2GIM9
M0QYT9
Q14653
Q96GL3
O94874
PDB IDs
1J2F
1QWT
1T2K
1ZOQ
2O61
2O6G
2PI0
3A77
3QU6
5JEJ
5JEK
5JEL
5JEM
5JEO
5JER
6SIV
6SJA
7JFL
8B9X
8C0D
8OHD
8OJ0
8OJ5
8OJ8
8QFC
8QFD
Enriched GO Terms of Interacting Partners
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Activation Of Innate Immune Response
Positive Regulation Of Type I Interferon Production
Defense Response To Virus
Response To Virus
Positive Regulation Of Innate Immune Response
Positive Regulation Of Interferon-beta Production
Immune System Process
Regulation Of Type I Interferon Production
Response To Other Organism
Response To External Biotic Stimulus
Innate Immune Response
Defense Response
Activation Of Immune Response
Regulation Of Defense Response
Canonical NF-kappaB Signal Transduction
Regulation Of Interferon-beta Production
Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Innate Immune Response-activating Signaling Pathway
Defense Response To Symbiont
Response To Stress
Defense Response To Other Organism
Positive Regulation Of Immune Response
Intracellular Signal Transduction
Regulation Of Immune Response
Immune Response
Positive Regulation Of Immune System Process
Cytoplasm
Immune Response-regulating Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Immune System Process
Protein Modification Process
Regulation Of Primary Metabolic Process
Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Gene Expression
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Tagcloud (Intersection)
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