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IRF3 and MAPK8
Number of citations of the paper that reports this interaction (PubMedID
19153595
)
0
Data Source:
BioGRID
(enzymatic study)
IRF3
MAPK8
Description
interferon regulatory factor 3
mitogen-activated protein kinase 8
Image
GO Annotations
Cellular Component
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Axon
Synapse
Basal Dendrite
Molecular Function
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Identical Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Nucleotide Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
JUN Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Enzyme Binding
Protein Phosphatase Binding
Histone Deacetylase Regulator Activity
Histone Deacetylase Binding
Protein Serine Kinase Activity
Protein Serine/threonine Kinase Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Cytokine Production
Immune System Process
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
DNA Damage Response
Cell Surface Receptor Signaling Pathway
MRNA Transcription
Response To Bacterium
Regulation Of Gene Expression
Programmed Cell Death
Signal Transduction Involved In Regulation Of Gene Expression
Lipopolysaccharide-mediated Signaling Pathway
Positive Regulation Of Type I Interferon Production
Response To Lipopolysaccharide
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Interferon-beta Production
Toll-like Receptor 4 Signaling Pathway
TRIF-dependent Toll-like Receptor Signaling Pathway
MDA-5 Signaling Pathway
Regulation Of Apoptotic Process
Positive Regulation Of Canonical NF-kappaB Signal Transduction
Response To Exogenous DsRNA
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Inflammatory Response
Defense Response To Virus
Type I Interferon-mediated Signaling Pathway
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Exogenous DsRNA
Macrophage Apoptotic Process
Programmed Necrotic Cell Death
Cellular Response To Virus
Antiviral Innate Immune Response
CGAS/STING Signaling Pathway
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
MAPK Cascade
Double-strand Break Repair
Protein Phosphorylation
Response To Oxidative Stress
JNK Cascade
JUN Phosphorylation
Response To UV
Response To Mechanical Stimulus
Positive Regulation Of Gene Expression
Regulation Of Macroautophagy
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Positive Regulation Of Cyclase Activity
Positive Regulation Of Cell Killing
Negative Regulation Of Protein Binding
Regulation Of Protein Localization
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
Cellular Response To Reactive Oxygen Species
Fc-epsilon Receptor Signaling Pathway
Regulation Of Circadian Rhythm
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
NLRP3 Inflammasome Complex Assembly
Rhythmic Process
Positive Regulation Of Protein Metabolic Process
Stress-activated MAPK Cascade
MRNA Destabilization
Protein Poly-ADP-ribosylation
Cellular Response To Lipopolysaccharide
Cellular Response To Mechanical Stimulus
Cellular Senescence
Energy Homeostasis
Positive Regulation Of NLRP3 Inflammasome Complex Assembly
Positive Regulation Of Establishment Of Protein Localization To Mitochondrion
Protein Localization To Site Of Double-strand Break
Pathways
ISG15 antiviral mechanism
IRF3 mediated activation of type 1 IFN
IRF3 mediated activation of type 1 IFN
DDX58/IFIH1-mediated induction of interferon-alpha/beta
LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production
Regulation of innate immune responses to cytosolic DNA
IRF3-mediated induction of type I IFN
Interferon gamma signaling
TICAM1-dependent activation of IRF3/IRF7
Interferon alpha/beta signaling
TRAF3-dependent IRF activation pathway
TRAF6 mediated IRF7 activation
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)
SARS-CoV-1 activates/modulates innate immune responses
SARS-CoV-2 activates/modulates innate and adaptive immune responses
Evasion by RSV of host interferon responses
Activation of BIM and translocation to mitochondria
Activation of BMF and translocation to mitochondria
NRAGE signals death through JNK
NRAGE signals death through JNK
NRIF signals cell death from the nucleus
Oxidative Stress Induced Senescence
FCERI mediated MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Activation of the AP-1 family of transcription factors
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Interleukin-38 signaling
WNT5:FZD7-mediated leishmania damping
Signaling by ALK fusions and activated point mutants
Drugs
Tamoxifen
Minocycline
Pyrazolanthrone
6-CHLORO-9-HYDROXY-1,3-DIMETHYL-1,9-DIHYDRO-4H-PYRAZOLO[3,4-B]QUINOLIN-4-ONE
2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE
N-(4-AMINO-5-CYANO-6-ETHOXYPYRIDIN-2-YL)-2-(4-BROMO-2,5-DIMETHOXYPHENYL)ACETAMIDE
5-CYANO-N-(2,5-DIMETHOXYBENZYL)-6-ETHOXYPYRIDINE-2-CARBOXAMIDE
2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide
Halicin
Diseases
GWAS
Autoimmune thyroid disease (
32581359
)
Schizophrenia (
29483656
)
Vitiligo (
27723757
)
Blood protein levels in cardiovascular risk (
28369058
)
Daytime sleep phenotypes (
27126917
)
Opioid dependence (time to event) (
34124712
)
Refractive error (
32231278
)
Interacting Genes
35 interacting genes:
CREBBP
EP300
EWSR1
FBXO7
GRIP1
HERC5
HSP90AA1
IKBKE
ILF3
IRF5
IRF7
JMJD6
MAPK8
MAVS
OGT
PEX19
PIAS4
PPIB
PRDX1
PSMD14
RB1
RBL1
RELA
SERPINB2
SGTA
SMURF2
SYT1
TBK1
TICAM1
TICAM2
TOMM70
TRIM26
TRIM55
TRIM63
UFL1
140 interacting genes:
AIMP1
AKT1
APBB2
APLP2
APP
ATF2
ATM
BAD
BCL2
BCL2L1
BCL2L11
BMF
BMPR2
CAMP
CASP3
CBL
CCDC88C
CDKN1A
CDKN2A
CDKN2C
CEBPA
COPS2
CRK
CTNNB1
DUSP1
DUSP10
DUSP16
DUSP22
DUSP4
DUSP7
EEF2K
EGFR
ELK1
ELK3
ELK4
ELP1
EP300
ETV1
FAM193B
FZR1
GANAB
GARS1
GEMIN5
GFPT1
GORASP2
GSTP1
GUCY1A1
H2AX
HDAC9
HIVEP1
HRAS
HSD17B4
HSF1
HSF4
HSPA8
ID2
IL27RA
IRAK1
IRF3
IRS1
ITCH
JDP2
JKAMP
JUN
JUNB
JUND
KRT8
MAP1B
MAP2K1
MAP2K2
MAP2K4
MAP2K7
MAP3K2
MAP3K7
MAPK1
MAPK14
MAPK3
MAPK8IP1
MAPK8IP2
MAPK8IP3
MAPKAP1
MAPKBP1
MAPT
MBP
METTL3
MKNK2
MYC
NCOA3
NFATC3
NFATC4
NFE2
NFE2L2
NKAPD1
NR3C1
NR4A1
PAX2
PDPK1
PIAS2
PIK3R1
PKMYT1
PNRC1
PPARG
PRKD1
PRKDC
PXN
RAD18
RAF1
RASSF1
RBM15
REL
RET
RPLP2
RPS6KB1
SCAND1
SCOC
SERPINB3
SH3BP5
SHC1
SIRT1
SMAD2
SMAD3
SNCA
SNCG
SP1
SPAG9
SPI1
SPIB
SSU72
STAT3
TFCP2
TNFSF11
TP53
TP73
TRAF6
WDR62
WWOX
XRCC6
YWHAZ
ZNF219
ZNF605
Entrez ID
3661
5599
HPRD ID
04769
03100
Ensembl ID
ENSG00000126456
ENSG00000107643
Uniprot IDs
E2GIM5
E2GIM6
E2GIM7
E2GIM8
E2GIM9
M0QYT9
Q14653
Q96GL3
A1L4K2
P45983
PDB IDs
1J2F
1QWT
1T2K
1ZOQ
2O61
2O6G
2PI0
3A77
3QU6
5JEJ
5JEK
5JEL
5JEM
5JEO
5JER
6SIV
6SJA
7JFL
1UKH
1UKI
2G01
2GMX
2H96
2NO3
2XRW
2XS0
3ELJ
3O17
3O2M
3PZE
3V3V
3VUD
3VUG
3VUH
3VUI
3VUK
3VUL
3VUM
4AWI
4E73
4G1W
4HYS
4HYU
4IZY
4L7F
4QTD
4UX9
4YR8
5LW1
6F5E
6ZR5
8PT8
8PT9
8PTA
8R5E
8X5M
9FT9
Enriched GO Terms of Interacting Partners
?
Activation Of Innate Immune Response
Positive Regulation Of Type I Interferon Production
Defense Response To Virus
Response To Virus
Positive Regulation Of Innate Immune Response
Positive Regulation Of Interferon-beta Production
Immune System Process
Regulation Of Type I Interferon Production
Response To Other Organism
Response To External Biotic Stimulus
Innate Immune Response
Defense Response
Activation Of Immune Response
Regulation Of Defense Response
Canonical NF-kappaB Signal Transduction
Regulation Of Interferon-beta Production
Regulation Of Innate Immune Response
Positive Regulation Of Defense Response
Innate Immune Response-activating Signaling Pathway
Defense Response To Symbiont
Response To Stress
Defense Response To Other Organism
Positive Regulation Of Immune Response
Intracellular Signal Transduction
Regulation Of Immune Response
Immune Response
Positive Regulation Of Immune System Process
Cytoplasm
Immune Response-regulating Signaling Pathway
Innate Immune Response Activating Cell Surface Receptor Signaling Pathway
Regulation Of Metabolic Process
Regulation Of Immune System Process
Protein Modification Process
Regulation Of Primary Metabolic Process
Immune Response-activating Signaling Pathway
Pattern Recognition Receptor Signaling Pathway
Positive Regulation Of Metabolic Process
Positive Regulation Of Multicellular Organismal Process
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Cytokine Production
Positive Regulation Of Type I Interferon-mediated Signaling Pathway
Cytoplasmic Pattern Recognition Receptor Signaling Pathway
Regulation Of Protein Metabolic Process
Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Cytokine-mediated Signaling Pathway
Regulation Of Canonical NF-kappaB Signal Transduction
Positive Regulation Of Interferon-alpha Production
Positive Regulation Of Response To Cytokine Stimulus
Positive Regulation Of Gene Expression
Intracellular Signal Transduction
Intracellular Signaling Cassette
Regulation Of Intracellular Signal Transduction
Signal Transduction
MAPK Cascade
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Response To Stress
Regulation Of Primary Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Cellular Response To Stress
Regulation Of Macromolecule Biosynthetic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Programmed Cell Death
Regulation Of Apoptotic Process
Regulation Of Macromolecule Metabolic Process
Regulation Of Gene Expression
Regulation Of Signal Transduction
Positive Regulation Of Metabolic Process
Regulation Of Metabolic Process
Cellular Developmental Process
Positive Regulation Of Intracellular Signal Transduction
Regulation Of Cell Population Proliferation
Response To Growth Factor
Regulation Of Signaling
Cellular Response To Oxygen-containing Compound
Regulation Of Cell Communication
Regulation Of DNA-templated Transcription
Positive Regulation Of Biosynthetic Process
Regulation Of RNA Biosynthetic Process
Regulation Of MAPK Cascade
Regulation Of Transcription By RNA Polymerase II
Response To Lipid
Positive Regulation Of Cell Communication
Positive Regulation Of Signaling
Nucleus
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Multicellular Organismal Process
Enzyme-linked Receptor Protein Signaling Pathway
Positive Regulation Of Signal Transduction
Response To Hormone
Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Regulation Of RNA Metabolic Process
Cell Surface Receptor Signaling Pathway
Programmed Cell Death
Cell Death
Regulation Of Cell Differentiation
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