IRF3 and TBK1

  • Number of citations of the paper that reports this interaction (PMID 12692549)
  • 461
  • Data Source:
  • BioGRID (enzymatic study)
  • HPRD (in vivo, in vitro)

IRF3

TBK1

Gene Name interferon regulatory factor 3 TANK-binding kinase 1
Image
Gene Ontology Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions 25 interactors: CREBBP EP300 EWSR1 GRIP1 HSP90AA1 IKBKE IRF5 IRF7 MAPK8 MAVS PEX19 PIAS4 PPIB PRDX1 RB1 RBL1 RELA SERPINB2 SGTA SMURF2 SYT1 TBK1 TICAM1 TICAM2 TOMM70A 38 interactors: AGO2 APP ATG9A AZI2 CALCOCO2 CDC37 CDC42BPG HSP90AA1 HSP90AB1 IKBKB IKBKE IKBKG IRF3 IRF5 IRF7 MAVS MBP MIB1 MIB2 MTPAP NCK1 NEDD4 NFKBIA OPTN PELI1 PROS1 RELA SIKE1 STX11 TANK TICAM1 TRAF2 TRAF3 TRAF3IP2 TRIM27 TXLNA TXLNG XIAP
Entrez ID 3661 29110
HPRD ID 04769 05322
Ensembl ID ENSG00000126456 ENSG00000183735
Uniprot IDs E2GIM5 E2GIM6 E2GIM7 E2GIM8 E2GIM9 M0QYT9 Q14653 Q9UHD2
PDB IDs 1J2F 1QWT 1T2K 1ZOQ 2O61 2O6G 2PI0 3A77 3QU6 4EFO 4EUT 4EUU 4IM0 4IM2 4IM3 4IW0 4IWO 4IWP 4IWQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
antiviral  called  cif  coactivator  composed  contain  creb  cytomegalovirus  defense  establishes  foreskin  hcmv  immediate  interacts  interferon  interferons  intrinsic  isg54  latent  numerous  participate  possess  responsive  shortcut  stat  stat1  stat2  stimulated  tentatively 
associates  bax  besides  characterizes  chemokines  cytochrome  cytosol  dispensable  hsp90  ikki  immediate  indispensable  initiates  initiating  irf3  leakage  mitochondrion  onto  outer  recruits  relocation  restrain  restrict  sacrifice  sendai  sev  tom70  triggers  uncovers 
Tagcloud (Difference) ?
antiviral  called  cif  coactivator  composed  contain  creb  cytomegalovirus  defense  establishes  foreskin  hcmv  interacts  interferon  interferons  intrinsic  isg54  latent  numerous  participate  possess  responsive  shortcut  stat  stat1  stat2  stimulated  tentatively 
associates  bax  besides  characterizes  chemokines  cytochrome  cytosol  dispensable  hsp90  ikki  indispensable  initiates  initiating  leakage  mitochondrion  onto  outer  recruits  relocation  restrain  restrict  sacrifice  sendai  sev  tom70  triggers  uncovers 
Tagcloud (Intersection) ?
immediate  irf3