GRK6 and SNCG

Number of citations of the paper that reports this interaction (PubMedID 10852916)
0

Data Source:
BioGRID (enzymatic study)

		GRK6	SNCG
Description		G protein-coupled receptor kinase 6	synuclein gamma
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Cytoplasm Golgi Apparatus Centrosome Spindle Cytosol Cytoskeleton Axon Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Protein Binding Cuprous Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway	Chemical Synaptic Transmission Adult Locomotory Behavior Protein Secretion Regulation Of Dopamine Secretion Regulation Of Neurotransmitter Secretion Synaptic Vesicle Endocytosis Synapse Organization
Pathways		G alpha (s) signalling events
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R	12 interacting genes: ADRB2 BUB1B GRK1 GRK5 GRK6 MAPK1 MAPK3 MAPK8 PCBP1 POT1 TERF1 TERF2IP
Entrez ID		2870	6623
HPRD ID		02925	04297
Ensembl ID		ENSG00000198055	ENSG00000173267
Uniprot IDs		B3KPS5 P43250	F8W754 O76070 Q6FHG5
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process	Positive Regulation Of Telomere Maintenance Protein Serine/threonine Kinase Activity Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Shelterin Complex G Protein-coupled Receptor Kinase Activity Protein Kinase Activity Nuclear Telomere Cap Complex G-rich Strand Telomeric DNA Binding Kinase Activity Telomere Capping MAP Kinase Activity Negative Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Stress-activated MAPK Cascade Positive Regulation Of Organelle Organization Stress-activated Protein Kinase Signaling Cascade RNA-templated DNA Biosynthetic Process Positive Regulation Of DNA Metabolic Process Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Interleukin-34-mediated Signaling Pathway Protein Phosphorylation Negative Regulation Of Telomere Maintenance Beta-adrenergic Receptor Kinase Activity Regulation Of Golgi Inheritance Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cellular Component Organization Phosphorylation Regulation Of Organelle Organization Caveolin-mediated Endocytosis Positive Regulation Of Macrophage Proliferation Phosphatase Binding Cardiac Neural Crest Cell Development Involved In Heart Development Trachea Formation Cellular Response To Amino Acid Starvation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Amino Acid Starvation Nucleobase-containing Compound Biosynthetic Process ATP Binding Regulation Of DNA Metabolic Process Outer Ear Morphogenesis ERBB3 Signaling Pathway ERBB2-ERBB3 Signaling Pathway Telomeric D-loop Disassembly Bergmann Glial Cell Differentiation Telomeric Loop Disassembly DNA Biosynthetic Process Telomere Maintenance
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