GRK6 and FSHR

Number of citations of the paper that reports this interaction (PubMedID 10379886)
0

Data Source:
HPRD (in vitro)

		GRK6	FSHR
Description		G protein-coupled receptor kinase 6	follicle stimulating hormone receptor
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Endosome Plasma Membrane Cell Surface Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	G Protein-coupled Receptor Activity Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Protein-hormone Receptor Activity Peptide Hormone Binding Signaling Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway	Ovarian Follicle Development Primary Ovarian Follicle Growth Regulation Of Systemic Arterial Blood Pressure Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Spermatogenesis Spermatid Development Female Gamete Generation Locomotory Behavior Gonad Development Male Gonad Development Female Gonad Development Response To Hormone Hormone-mediated Signaling Pathway Intracellular Water Homeostasis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Protein Kinase A Signaling Ovulation Cycle Process Neuron Projection Development Regulation Of Hormone Metabolic Process Regulation Of Chromosome Organization Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Sperm DNA Condensation Follicle-stimulating Hormone Signaling Pathway Regulation Of MAPK Cascade Transcytosis Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Sertoli Cell Development Sertoli Cell Proliferation Uterus Development Regulation Of Acetylcholine Metabolic Process Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus Basement Membrane Organization
Pathways		G alpha (s) signalling events	Hormone ligand-binding receptors G alpha (s) signalling events
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases			Ovarian hyperstimulation syndrome (OHSS) Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis
GWAS		Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Daytime nap ( 33568662) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) HDL cholesterol levels in HIV infection ( 33109212) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Recurrent major depressive disorder ( 34099189) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R	21 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 SNCA TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		2870	2492
HPRD ID		02925	00639
Ensembl ID		ENSG00000198055	ENSG00000170820
Uniprot IDs		B3KPS5 P43250	B4DXB5 P23945
PDB IDs		2ACX 3NYN 3NYO	1XWD 4AY9 4MQW 8I2G 8I2H
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process	Protein Tag Activity G Protein-coupled Receptor Kinase Activity Receptor Internalization Receptor-mediated Endocytosis Follicle-stimulating Hormone Activity Follicle-stimulating Hormone Complex Endocytic Vesicle Membrane Follicle-stimulating Hormone Signaling Pathway Mitochondrial Outer Membrane Beta-adrenergic Receptor Kinase Activity Endosome Membrane Regulation Of G Protein-coupled Receptor Signaling Pathway Vesicle Protein Serine/threonine Kinase Activity Protein Domain Specific Binding Endocytosis Ubiquitin Protein Ligase Binding Negative Regulation Of Relaxation Of Smooth Muscle Import Into Cell Regulation Of Catecholamine Secretion Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Lipid Metabolic Process Cell Cortex Cellular Response To High Light Intensity Positive Regulation Of Lipid Metabolic Process Positive Regulation Of D-glucose Import Positive Regulation Of D-glucose Transmembrane Transport Phosphoprotein Binding Synaptic Vesicle Endocytosis Presynaptic Endocytosis Proteolysis Involved In Protein Catabolic Process Ovulation Cycle Process Positive Regulation Of Steroid Biosynthetic Process Positive Regulation Of Steroid Metabolic Process Extracellular Space Protein Ubiquitination Protein Modification By Small Protein Conjugation Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Beta-tubulin Binding Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Ribosome Negative Regulation Of Transport Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Edg-2 Lysophosphatidic Acid Receptor Binding Protein Modification Process Response To High Light Intensity
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?