GRK6 and EDNRA

Number of citations of the paper that reports this interaction (PubMedID 9211925)
0

Data Source:
HPRD (in vitro)

		GRK6	EDNRA
Description		G protein-coupled receptor kinase 6	endothelin receptor type A
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway	Mitotic Cell Cycle Angiogenesis Branching Involved In Blood Vessel Morphogenesis Response To Hypoxia In Utero Embryonic Development Blood Vessel Remodeling Response To Amphetamine Regulation Of Heart Rate Heart Process Glomerular Filtration Cardiac Chamber Formation Left Ventricular Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Tissue Development Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Noradrenergic Neuron Differentiation Intracellular Calcium Ion Homeostasis Smooth Muscle Contraction Mitochondrion Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Axon Guidance Heart Development Respiratory Gaseous Exchange By Respiratory System Regulation Of Blood Pressure Cell Population Proliferation Response To Wounding Gene Expression Regulation Of D-glucose Transmembrane Transport Neural Crest Cell Development Neural Crest Cell Differentiation Neural Crest Cell Fate Commitment Artery Smooth Muscle Contraction Vascular Associated Smooth Muscle Contraction Neuron Remodeling Heparin Proteoglycan Metabolic Process Thyroid Gland Development Neuron Projection Development Glomerulus Development Cellular Response To Oxidative Stress Embryonic Heart Tube Development Aorta Development Vasoconstriction Norepinephrine Metabolic Process Middle Ear Morphogenesis Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Human Chorionic Gonadotropin Stimulus Developmental Pigmentation Enteric Nervous System Development Sympathetic Nervous System Development Axon Extension Embryonic Skeletal System Development Neuromuscular Process Sodium Ion Homeostasis Canonical Wnt Signaling Pathway Head Development Face Development Axonogenesis Involved In Innervation Establishment Of Endothelial Barrier Pharyngeal Arch Artery Morphogenesis Renal Sodium Ion Absorption Calcium Ion Transmembrane Transport Cellular Response To Follicle-stimulating Hormone Stimulus Cellular Response To Luteinizing Hormone Stimulus Protein Transmembrane Transport Glomerular Endothelium Development Podocyte Differentiation Endothelin Receptor Signaling Pathway Endothelin Receptor Signaling Pathway Involved In Heart Process Renal Albumin Absorption Vascular Associated Smooth Muscle Cell Development Mesenchymal Cell Apoptotic Process Cellular Response To Toxic Substance Sympathetic Neuron Axon Guidance CAMP/PKA Signal Transduction Semaphorin-plexin Signaling Pathway Involved In Axon Guidance Podocyte Apoptotic Process Meiotic Cell Cycle Process Involved In Oocyte Maturation Cranial Skeletal System Development Response To Acetylcholine Regulation Of Protein Localization To Cell Leading Edge Positive Regulation Of Cation Channel Activity
Pathways		G alpha (s) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs			Bosentan Acetylsalicylic acid 2-HYDROXY-3,5-DIIODOBENZOIC ACID Darusentan SPP 301 Actelion-1 Atrasentan Sitaxentan Ambrisentan Enrasentan Tezosentan Clazosentan Macitentan Sparsentan
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Carotid intima media thickness ( 21909108) Carotid plaque ( 30510157) Coronary artery disease ( 33020668 24262325 32469254 26343387 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Lead levels ( 26025379) Myocardial infarction ( 33532862 26343387) Obesity-related traits ( 23251661) Pancreatic cancer ( 29422604) Pancreatic ductal adenocarcinoma ( 30541042) Peripheral artery disease ( 26488411 31285632) Plasma clusterin levels ( 26545630) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Resting heart rate ( 27798624) Serum bilirubin levels x Mediterranean diet adherence interaction in metabolic syndrome ( 30621171) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R	7 interacting genes: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2870	1909
HPRD ID		02925	00571
Ensembl ID		ENSG00000198055	ENSG00000151617
Uniprot IDs		B3KPS5 P43250	P25101
PDB IDs		2ACX 3NYN 3NYO	8HCQ 8XVI 8XVJ 8XVK 8XVL
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process	Vein Smooth Muscle Contraction Endothelin B Receptor Binding Regulation Of Systemic Arterial Blood Pressure By Endothelin Artery Smooth Muscle Contraction Tonic Smooth Muscle Contraction Positive Regulation Of Urine Volume Endothelin Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Hormone Secretion Vascular Associated Smooth Muscle Contraction Guanyl Nucleotide Binding Regulation Of Urine Volume Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Regulation Of Blood Pressure Regulation Of Secretion By Cell G Protein-coupled Acetylcholine Receptor Signaling Pathway G-protein Beta/gamma-subunit Complex Binding Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Regulation Of Secretion Positive Regulation Of Smooth Muscle Contraction Vasoconstriction Heterotrimeric G-protein Complex Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Heart Contraction Regulation Of Cell Differentiation Regulation Of Hormone Secretion Positive Regulation Of Cell Cycle Process Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of Mitotic Nuclear Division Axon Extension Positive Regulation Of Secretion By Cell Positive Regulation Of Muscle Contraction Postsynaptic Signal Transduction Neural Crest Cell Migration Neutrophil Chemotaxis Positive Regulation Of Secretion Mesenchymal Cell Migration Smooth Muscle Contraction Positive Regulation Of Cell Cycle Regulation Of Smooth Muscle Contraction Regulation Of Interleukin-2 Production Regulation Of Vasoconstriction Neutrophil Migration
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