GRK6 and EDNRA

Number of citations of the paper that reports this interaction (PMID 9211925)
37

Data Source:
HPRD (in vitro)

		GRK6	EDNRA
Gene Name		G protein-coupled receptor kinase 6	endothelin receptor type A
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Plasma Membrane Integral Component Of Plasma Membrane T-tubule Nuclear Membrane Membrane Raft
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	Phosphatidylinositol Phospholipase C Activity Endothelin Receptor Activity Protein Binding
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Patterning Of Blood Vessels Response To Hypoxia In Utero Embryonic Development Histamine Secretion Positive Regulation Of Protein Phosphorylation Glomerular Filtration Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Rho Protein Signal Transduction Heart Development Aging Respiratory Gaseous Exchange Metabolic Process Regulation Of Blood Pressure Cell Proliferation Positive Regulation Of Cell Proliferation Neural Crest Cell Development Artery Smooth Muscle Contraction Glucose Transport Sensory Perception Of Pain Negative Regulation Of CAMP Biosynthetic Process Response To Lipopolysaccharide Vasoconstriction Positive Regulation Of Odontogenesis Negative Regulation Of Apoptotic Process Penile Erection Response To Morphine Fibroblast Proliferation Enteric Nervous System Development Smooth Muscle Cell Proliferation Regulation Of Epithelial Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Maternal Process Involved In Parturition Head Development Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Endothelin Receptor Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Kidney Development
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Bosentan 2-HYDROXY-3,5-DIIODOBENZOIC ACID Sitaxentan
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)	Carotid intima media thickness ( 21909108) Dental caries ( 23064961) Intracranial aneurysm ( 22286173) Obesity-related traits ( 23251661)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	7 interactors: EDN1 EDN3 GNA11 GNAI2 GRK6 HDAC7 KAT5
Entrez ID		2870	1909
HPRD ID		02925	00571
Ensembl ID		ENSG00000198055	ENSG00000151617
Uniprot IDs		P43250	P25101
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Vein Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Endothelin Vascular Smooth Muscle Contraction Inositol Phosphate-mediated Signaling Negative Regulation Of Interleukin-2 Production Positive Regulation Of Heart Rate Regulation Of Developmental Pigmentation Cell Activation Signal Transduction Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Heart Contraction Cell Surface Receptor Signaling Pathway Negative Regulation Of CAMP Metabolic Process Vasoconstriction Signaling Cell Communication Negative Regulation Of Nucleotide Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Protein Modification Process Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Cellular Component Movement Positive Regulation Of Locomotion Positive Regulation Of Endothelial Cell Migration Regulation Of Vasoconstriction Smooth Muscle Contraction Cellular Response To Stimulus Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cellular Protein Metabolic Process Developmental Pigmentation Peptide Hormone Secretion Neural Crest Cell Development Positive Regulation Of Leukocyte Chemotaxis Peptide Secretion Regulation Of Blood Vessel Size Regulation Of Tube Size Regulation Of Heart Rate Positive Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Neural Crest Cell Differentiation Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Protein Kinase Activity Hormone Secretion Positive Regulation Of Leukocyte Migration Regulation Of CAMP Biosynthetic Process Positive Regulation Of Kinase Activity Phospholipase D-activating G-protein Coupled Receptor Signaling Pathway Protein Kinase C Deactivation Negative Regulation Of Biosynthetic Process Hormone Transport
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	aacr acquire arr1 arrb1 arrestin chemoresistance chemoresistant cisplatinum edn1 emt endothelin eoc et etar etbr impairing intravasation links macitentan overcome paucity pharmacologic potentiation rationale reorganization res sustain sustains vascularization
Tagcloud (Intersection) ?