GRK6 and BDKRB2

Number of citations of the paper that reports this interaction (PMID 11517230)
13

Data Source:
HPRD (in vitro, in vivo)

		GRK6	BDKRB2
Gene Name		G protein-coupled receptor kinase 6	bradykinin receptor B2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	Protease Binding Phosphatidylinositol Phospholipase C Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	12 interactors: ACE ADRBK1 ADRBK2 AGTR1 GNA11 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		2870	624
HPRD ID		02925	00213
Ensembl ID		ENSG00000198055	ENSG00000168398
Uniprot IDs		P43250	P30411
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Vasodilation Negative Regulation Of Signal Transduction Blood Circulation Regulation Of The Force Of Heart Contraction Signal Transduction Regulation Of Signal Transduction Receptor Internalization Blood Coagulation Signaling Hemostasis Regulation Of Blood Pressure Regulation Of Signaling Cell Communication Positive Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Arginine Catabolic Process Cellular Response To Stimulus Tachykinin Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Guanylate Cyclase Activity Response To Wounding Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Protein Phosphorylation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Surface Receptor Signaling Pathway Negative Regulation Of Platelet Activation Cellular Protein Metabolic Process Nitric Oxide Mediated Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Protein Modification Process Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of MRNA Catabolic Process Regulation Of Catalytic Activity Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Intersection) ?