GRK6 and RCVRN

Number of citations of the paper that reports this interaction (PubMedID 12507501)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRK6	RCVRN
Description		G protein-coupled receptor kinase 6	recoverin
Image
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Photoreceptor Outer Segment Photoreceptor Inner Segment Membrane Dendrite Cell Projection Perikaryon
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity Metal Ion Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway	Signal Transduction Visual Perception Phototransduction Regulation Of Signal Transduction Regulation Of Calcium Ion Transport
Pathways		G alpha (s) signalling events	Inactivation, recovery and regulation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade
Drugs			Myristic acid
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R	11 interacting genes: CAV1 GIT2 GRK1 GRK2 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		2870	5957
HPRD ID		02925	01558
Ensembl ID		ENSG00000198055	ENSG00000109047
Uniprot IDs		B3KPS5 P43250	P35243
PDB IDs		2ACX 3NYN 3NYO	2D8N
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Protein Serine/threonine Kinase Activity Gastrulation Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Protein Kinase Activity Animal Organ Development Regulation Of Signal Transduction Kinase Activity Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Double-stranded DNA Binding G Protein-coupled Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway SMAD Protein Signal Transduction Release Of Cytochrome C From Mitochondria RRNA Transcription Regulation Of The Force Of Heart Contraction ATP Binding Embryonic Cranial Skeleton Morphogenesis Activin Receptor Signaling Pathway Negative Regulation Of Fibroblast Proliferation Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Death Programmed Cell Death Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Programmed Necrotic Cell Death Signal Transduction Fibroblast Proliferation Positive Regulation Of SMAD Protein Signal Transduction Negative Regulation Of Relaxation Of Smooth Muscle Regulation Of Muscle System Process Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Inward Rectifier Potassium Channel Inhibitor Activity Leukocyte Activation Somitogenesis Segmentation Negative Regulation Of Lung Blood Pressure In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Chordate Embryonic Development Nuclear Mineralocorticoid Receptor Binding Transcription Coactivator Binding Cell Proliferation Involved In Endocardial Cushion Morphogenesis Positive Regulation Of Tolerance Induction To Self Antigen Superior Endocardial Cushion Morphogenesis
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