GRK6 and RHO

Number of citations of the paper that reports this interaction (PMID 8366096)
19

Data Source:
HPRD (in vitro)

		GRK6	RHO
Gene Name		G protein-coupled receptor kinase 6	rhodopsin
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Golgi-associated Vesicle Membrane Rough Endoplasmic Reticulum Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Photoreceptor Disc Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	G-protein Coupled Receptor Activity Protein Binding Photoreceptor Activity Retinal Binding Spectrin Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Retinoid Metabolic Process Protein Phosphorylation Organelle Organization G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Red, Far-red Light Phototransduction Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Retina Development In Camera-type Eye
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Opsins VxPx cargo-targeting to cilium Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction The phototransduction cascade The canonical retinoid cycle in rods (twilight vision) G alpha (i) signalling events
Drugs			Halothane N-Acetylmethionine 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Phosphonothreonine Beta-D-Mannose Alpha-D-Mannose B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Lauryl Dimethylamine-N-Oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Phosphonoserine
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	10 interactors: ADRBK1 ARR3 DERL1 GNGT1 GRK1 GRK5 GRK6 PPP2CA PRKCA SAG
Entrez ID		2870	6010
HPRD ID		02925	01584
Ensembl ID		ENSG00000198055	ENSG00000163914
Uniprot IDs		P43250	P08100
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Light Stimulus Cellular Response To Radiation Signal Transduction Detection Of Abiotic Stimulus Signaling Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Response To Light Stimulus Apoptotic Process Response To Radiation Response To Stimulus Programmed Cell Death Cell Death Death Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Detection Of Stimulus Response To Fibroblast Growth Factor Cellular Protein Modification Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Protein Autophosphorylation Protein Phosphorylation Peptidyl-threonine Phosphorylation Photoreceptor Cell Development Activation Of Phospholipase C Activity Protein Metabolic Process Positive Regulation Of Phospholipase C Activity Nuclear Envelope Organization Negative Regulation Of Apoptotic Process
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr
Tagcloud (Intersection) ?