GRK6 and SNCA

Number of citations of the paper that reports this interaction (PMID 10852916)
68

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		GRK6	SNCA
Gene Name		G protein-coupled receptor kinase 6	synuclein, alpha (non A4 component of amyloid precursor)
Image
Gene Ontology Annotations	Cellular Component	Membrane	Extracellular Region Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Respiratory Chain Complex I Lysosome Rough Endoplasmic Reticulum Golgi Apparatus Cytosol Ribosome Plasma Membrane Cell Cortex Synaptic Vesicle Actin Cytoskeleton Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Terminal Bouton Fibril Perinuclear Region Of Cytoplasm
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	Magnesium Ion Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Microtubule Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Protein Domain Specific Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Phospholipase Binding Transcription Regulatory Region DNA Binding Dynein Binding Protein N-terminus Binding Tau Protein Binding Beta-tubulin Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Microglial Cell Activation Positive Regulation Of Receptor Recycling Negative Regulation Of Protein Phosphorylation Positive Regulation Of Neurotransmitter Secretion Fatty Acid Metabolic Process Neutral Lipid Metabolic Process Phospholipid Metabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Mitochondrial Membrane Organization Aging Adult Locomotory Behavior Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Glutamate Secretion Regulation Of Dopamine Secretion Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation Regulation Of Locomotion Dopamine Biosynthetic Process Response To Drug Mitochondrial ATP Synthesis Coupled Electron Transport Regulation Of Macrophage Activation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Extracellular Fibril Organization Negative Regulation Of Neuron Apoptotic Process Cellular Response To Fibroblast Growth Factor Stimulus Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Negative Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Regulation Of Long-term Neuronal Synaptic Plasticity Synaptic Vesicle Endocytosis Synapse Organization Regulation Of Acyl-CoA Biosynthetic Process Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Regulation Of Excitatory Postsynaptic Membrane Potential Long-term Synaptic Potentiation Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process
Pathways			Amyloids
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)	Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 22438815 20070850 21044948 21738487)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	110 interactors: A1BG ACTA1 ADAP2 ADRBK1 AKT1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BAX BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 COX1 COX3 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CYCS DMTN DOCK7 DYNC1H1 DYRK1A EEF1A1 EIF3G ELK1 ENC1 ENSA FGR FKBP4 FYN GABARAPL1 GAPDH GRK1 GRK5 GRK6 GSK3B HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D NEDD4 NEDD4L PAK3 PARK2 PDE4DIP PELP1 PFDN2 PINK1 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PRKCE PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPT4 SIAH1 SIAH2 SLC6A3 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI SUMO2 SYK SYN1 TGM1 TH TOR1A TUBA1A UBB UBC USP47 YWHAB YWHAE YWHAH
Entrez ID		2870	6622
HPRD ID		02925	01227
Ensembl ID		ENSG00000198055	ENSG00000145335
Uniprot IDs		P43250	H6UYS0 H6UYS5 P37840
PDB IDs		2ACX 3NYN 3NYO	1XQ8 2JN5 2KKW 2M55 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Regulation Of Signaling Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Regulation Of Cellular Localization Cell Death Death Regulation Of Cell Death Apoptotic Process Response To Abiotic Stimulus Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Intracellular Transport Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Proteolysis Positive Regulation Of Metabolic Process Response To Organic Substance Negative Regulation Of Apoptotic Process Nervous System Development Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Intrinsic Apoptotic Signaling Pathway Response To Stimulus System Development Negative Regulation Of Protein Metabolic Process Phosphorylation Negative Regulation Of Cellular Protein Metabolic Process Response To Stress Negative Regulation Of Cell Death Regulation Of Intracellular Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Death Cell Communication Cell Differentiation Positive Regulation Of Cellular Protein Metabolic Process Signaling Intracellular Signal Transduction Positive Regulation Of Proteolysis Enzyme Linked Receptor Protein Signaling Pathway Generation Of Neurons Cellular Protein Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Response To External Stimulus Regulation Of Phosphorylation Neurotrophin TRK Receptor Signaling Pathway
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	2de angustifolia apoa1 atp5a1 atp5a1were bioinformatics caliber david diminishing dysregulated histopathology hspa5 kegg la lavandula lavender le likewise ontology operate pharmaceutically prdx2 predictedinteractions scrutinized searching slowing string sum tof
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