GRK6 and CHRM3

Number of citations of the paper that reports this interaction (PMID 11856737)
11

Data Source:
HPRD (in vitro)

		GRK6	CHRM3
Gene Name		G protein-coupled receptor kinase 6	cholinergic receptor, muscarinic 3
Image
Gene Ontology Annotations	Cellular Component	Membrane	Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Cell Junction Dendrite Asymmetric Synapse Axon Terminus Postsynaptic Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	Phosphatidylinositol Phospholipase C Activity Receptor Activity Protein Binding Drug Binding G-protein Coupled Acetylcholine Receptor Activity Acetylcholine Binding
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Regulation Of Vascular Smooth Muscle Contraction Energy Reserve Metabolic Process Cellular Protein Modification Process Smooth Muscle Contraction Signal Transduction G-protein Coupled Receptor Signaling Pathway G-protein Coupled Acetylcholine Receptor Signaling Pathway Nervous System Development Cell Proliferation Small Molecule Metabolic Process Positive Regulation Of Smooth Muscle Contraction Saliva Secretion Regulation Of Insulin Secretion
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Acetylcholine regulates insulin secretion Integration of energy metabolism Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Muscarinic acetylcholine receptors Regulation of insulin secretion Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Cevimeline Tramadol Succinylcholine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Clozapine Trihexyphenidyl Oxyphencyclimine Procyclidine Promazine Hyoscyamine Cyproheptadine Imipramine Methylscopolamine Darifenacin Tridihexethyl Anisotropine Methylbromide Nortriptyline Atropine Nicardipine Paroxetine Homatropine Methylbromide Diphemanil Methylsulfate Scopolamine Benzquinamide Propiomazine Cryptenamine Tropicamide Brompheniramine Maprotiline Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Desipramine Quetiapine Mivacurium Diphenidol Aripiprazole Chlorprothixene Pancuronium Pipecuronium Methotrimeprazine Tiotropium Solifenacin Isopropamide Mepenzolate Fesoterodine Methacholine Aclidinium
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)	Epilepsy (generalized) ( 22949513) Hypertension ( 17554300) Platelet counts ( 21507922) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	9 interactors: ARF1 ARF6 CSNK1A1 GNAQ GPRASP1 GRK6 GZMB PPP1R9B SET
Entrez ID		2870	1131
HPRD ID		02925	00329
Ensembl ID		ENSG00000198055
Uniprot IDs		P43250	P20309
PDB IDs		2ACX 3NYN 3NYO	2CSA
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	Regulation Of Organelle Organization Regulation Of Signaling Regulation Of Cellular Component Organization Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Signal Transduction G-protein Coupled Receptor Catabolic Process Regulation Of Opioid Receptor Signaling Pathway Signaling Cell Cycle Cell Communication Cellular Response To Morphine Cellular Response To Isoquinoline Alkaloid Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Establishment Of Protein Localization Granzyme-mediated Apoptotic Signaling Pathway Regulation Of Cellular Process Regulation Of Endocytosis Negative Regulation Of Catalytic Activity Cellular Response To Stimulus Regulation Of Protein Localization Myeloid Cell Apoptotic Process Phospholipase C-activating Dopamine Receptor Signaling Pathway Organelle Organization Intracellular Signal Transduction Neuron Remodeling Protein Localization To Endosome COPI-coated Vesicle Budding Regulation Of Exit From Mitosis COPI Coating Of Golgi Vesicle Wnt Signaling Pathway Regulation Of Melanocyte Differentiation Golgi Vesicle Budding Regulation Of Cellular Localization Regulation Of Synaptic Transmission Nucleosome Disassembly Maternal Behavior Long Term Synaptic Depression Establishment Of Epithelial Cell Polarity Filopodium Assembly Cellular Copper Ion Homeostasis Protein Localization To Cell Surface Metabolic Process Cell Projection Organization Cellular Response To Ammonium Ion Hepatocyte Apoptotic Process Receptor Catabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Actin Cytoskeleton Organization
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	additions adenocarcinomas animal aom attenuates azoxymethane bethanechol bethenechol chloride colonic drinking euthanized injections intestinal intraperitoneal m3r metalloproteinase mmp10 mmp13 mmp7 mucosa muscarinic name neoplasia nicotinic prominent strikingly thickness
Tagcloud (Intersection) ?