GRK6 and LTB4R

Number of citations of the paper that reports this interaction (PubMedID 12077128)
0

Data Source:
HPRD (in vitro)

		GRK6	LTB4R
Description		G protein-coupled receptor kinase 6	leukotriene B4 receptor
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Beta-adrenergic Receptor Kinase Activity	Nucleotide Binding Leukotriene B4 Receptor Activity G Protein-coupled Receptor Activity Leukotriene Receptor Activity G Protein-coupled Peptide Receptor Activity
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Wnt Signaling Pathway	Muscle Contraction Inflammatory Response Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Leukotriene Signaling Pathway
Pathways		G alpha (s) signalling events	Leukotriene receptors G alpha (q) signalling events
Drugs			Amelubant Morniflumate Leukotriene B4
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Neutrophil percentage of white cells ( 32888494) Tinnitus ( 33742053) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Parent of origin effect on language impairment (paternal) ( 24571439)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R NHERF1 PRSS23 RCVRN RHO SNCA SNCB SNCG TBXA2R	4 interacting genes: GNA15 GNAI2 GRK6 YWHAG
Entrez ID		2870	1241
HPRD ID		02925	03320
Ensembl ID		ENSG00000198055	ENSG00000213903
Uniprot IDs		B3KPS5 P43250	Q15722
PDB IDs		2ACX 3NYN 3NYO	7K15 7VKT
Enriched GO Terms of Interacting Partners?		Smooth Muscle Contraction G Protein-coupled Receptor Activity Muscle Contraction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway System Process Muscle System Process Cuprous Ion Binding Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vascular Process In Circulatory System Blood Vessel Diameter Maintenance Regulation Of Tube Size Regulation Of Cell Communication Regulation Of Signaling Regulation Of Blood Pressure Circulatory System Process Endothelin Receptor Activity Regulation Of System Process Renal Sodium Ion Transport Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Monoatomic Ion Transport Vasoconstriction Renal Albumin Absorption Regulation Of Multicellular Organismal Process Signal Transduction Synaptic Vesicle Endocytosis Type 1 Angiotensin Receptor Binding Regulation Of Signal Transduction Secretion Renal Absorption Catecholamine Metabolic Process Presynaptic Endocytosis Regulation Of Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Biological Quality Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Renal Protein Absorption Vasodilation Regulation Of Metal Ion Transport Axon Terminus Regulation Of Smooth Muscle Contraction Locomotory Behavior Biogenic Amine Metabolic Process Cellular Response To Follicle-stimulating Hormone Stimulus Heparin Proteoglycan Metabolic Process Enteric Nervous System Development Endothelin Receptor Signaling Pathway Podocyte Differentiation Amine Metabolic Process	G Protein-coupled Acetylcholine Receptor Signaling Pathway Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex Acetylcholine Receptor Signaling Pathway Postsynaptic Signal Transduction G Protein-coupled Receptor Binding Positive Regulation Of T Cell Mediated Immunity Negative Regulation Of Adaptive Immune Response Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Positive Regulation Of T Cell Costimulation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Activation G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Catalytic Activity Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Defense Response To Nematode Protein Kinase C Inhibitor Activity Signal Transduction Negative Regulation Of Lymphocyte Activation Beta-adrenergic Receptor Kinase Activity Negative Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Isotype Switching To IgE Isotypes Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Regulation Of Lymphocyte Mediated Immunity Negative Regulation Of Immune Response Regulation Of Adaptive Immune Response Negative Regulation Of Cell Activation Negative Regulation Of Regulatory T Cell Differentiation G Protein-coupled Receptor Kinase Activity Positive Regulation Of T-helper 2 Cell Differentiation Tumor Necrosis Factor Receptor Superfamily Binding Positive Regulation Of T Cell Activation Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway Negative Regulation Of Calcium Ion-dependent Exocytosis G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Immune Effector Process Positive Regulation Of Memory T Cell Differentiation Positive Regulation Of Leukocyte Cell-cell Adhesion
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