GRK6 and LTB4R

Number of citations of the paper that reports this interaction (PMID 12077128)
10

Data Source:
HPRD (in vitro)

		GRK6	LTB4R
Gene Name		G protein-coupled receptor kinase 6	leukotriene B4 receptor
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Membrane	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity Protein Binding ATP Binding	Nucleotide Binding Leukotriene B4 Receptor Activity Leukotriene Receptor Activity
	Biological Process	Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway	Movement Of Cell Or Subcellular Component Muscle Contraction Inflammatory Response Immune Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway
Pathways			G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Leukotriene receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Eicosanoid ligand-binding receptors
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Chronic kidney disease ( 20383146) Metabolite levels ( 22916037)
Protein-Protein Interactions		18 interactors: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	4 interactors: GNA15 GNAI2 GRK6 YWHAG
Entrez ID		2870	1241
HPRD ID		02925	03320
Ensembl ID		ENSG00000198055	ENSG00000213903
Uniprot IDs		P43250	Q15722
PDB IDs		2ACX 3NYN 3NYO
Enriched GO Terms of Interacting Partners?		G-protein Coupled Receptor Signaling Pathway Signaling Cell Communication Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Smooth Muscle Contraction Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Cyclase Activity Regulation Of Ion Transport Regulation Of Blood Vessel Size Regulation Of Tube Size Muscle Contraction Endothelin Receptor Signaling Pathway Signal Transduction Muscle System Process Vasoconstriction Vasodilation Response To External Stimulus Regulation Of Signaling Blood Circulation Response To Stimulus Negative Regulation Of Nucleotide Metabolic Process Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Lyase Activity Regulation Of Protein Phosphorylation Regulation Of Cell Death Regulation Of Smooth Muscle Contraction Regulation Of Blood Pressure Cytosolic Calcium Ion Homeostasis Regulation Of Adenylate Cyclase Activity Regulation Of Vasoconstriction Cellular Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Phosphorylation Positive Regulation Of Cyclic Nucleotide Metabolic Process Cellular Chemical Homeostasis Negative Regulation Of Apoptotic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Programmed Cell Death Sensory Perception Of Pain Enteric Nervous System Development Response To Ammonium Ion Ion Homeostasis Vascular Smooth Muscle Contraction Renal System Process Response To Stress	G-protein Coupled Acetylcholine Receptor Signaling Pathway Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Platelet Activation Phospholipase C-activating G-protein Coupled Acetylcholine Receptor Signaling Pathway Regulation Of Synaptic Transmission Phospholipase C-activating Dopamine Receptor Signaling Pathway Blood Coagulation Hemostasis Adenosine Receptor Signaling Pathway Signal Transduction Signaling Regulation Of Body Fluid Levels Cell Communication Negative Regulation Of Adenylate Cyclase Activity Wound Healing Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Catalytic Activity Negative Regulation Of Lyase Activity Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of CAMP Biosynthetic Process Cell Activation Response To Wounding Gamma-aminobutyric Acid Signaling Pathway Negative Regulation Of CAMP Metabolic Process Regulation Of Protein Kinase Activity Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Signal Transduction Dopamine Receptor Signaling Pathway Cellular Response To Stimulus Negative Regulation Of Catalytic Activity Regulation Of Kinase Activity Negative Regulation Of Nucleotide Metabolic Process Regulation Of Signaling Cell Surface Receptor Signaling Pathway Activation Of Phospholipase C Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Mitochondrion Organization Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Termination Of Signal Transduction Activation Of MAPKK Activity Regulation Of Cyclase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Phospholipase Activity G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling
Tagcloud ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	10d a2a adenosine adora1 adora2a adora3 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Difference) ?		apparent appear autoinhibitory autophosphorylated autophosphorylation ca2 calmodulin conservation contributes coupled define deletion domain evolutionary example functionally grk4 grk5 grks localization nonreceptor palmitoylated phospholipid phospholipids phosphorylated residues subject substrates translational	10d a2a adenosine adora1 adora2a adora3 c5ar1 calving chemoattractant deaminase holstein hydroxybutyrate leukotriene mcal multiparous nonesterified nucleotidase p2ry2 p2y parturition peripartal pmnl ptafr purinergic sell selplg slc29a1 slc29a2
Tagcloud (Intersection) ?