RACGAP1 and AURKB

Number of citations of the paper that reports this interaction (PubMedID 12689593)
0

Data Source:
BioGRID (enzymatic study, enzymatic study)
HPRD (in vivo, in vitro)

		RACGAP1	AURKB
Description		Rac GTPase activating protein 1	aurora kinase B
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Chromosome, Centromeric Region Kinetochore Condensed Chromosome, Centromeric Region Spindle Pole Nucleus Nucleoplasm Chromosome Cytoplasm Centrosome Spindle Cytosol Cytoskeleton Spindle Microtubule Chromocenter Microtubule Cytoskeleton Midbody Chromosome Passenger Complex Spindle Midzone Mitotic Spindle Pole Mitotic Spindle Midzone
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Kinase Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport	Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Mitotic Cytokinesis Negative Regulation Of B Cell Apoptotic Process Spindle Organization Mitotic Spindle Organization Positive Regulation Of Microtubule Depolymerization Positive Regulation Of Telomere Maintenance Regulation Of Cytokinesis Negative Regulation Of Cytokinesis Positive Regulation Of Cytokinesis Regulation Of Microtubule-based Process Protein Localization To Kinetochore Cellular Response To UV Cleavage Furrow Formation Post-translational Protein Modification Cell Cycle G2/M Phase Transition Mitotic Cytokinesis Checkpoint Signaling Negative Regulation Of Innate Immune Response Mitotic Spindle Midzone Assembly Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Chromosome Segregation Midbody Abscission Positive Regulation Of Mitotic Sister Chromatid Segregation Positive Regulation Of Cell Cycle Process Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Mitotic Spindle Assembly Repair Of Mitotic Kinetochore Microtubule Attachment Defect CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Mitotic Sister Chromatid Separation Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Mitotic Cytokinesis Positive Regulation Of Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore Mitotic Sister Chromatid Biorientation
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Regulation of TP53 Activity through Phosphorylation Mitotic Prometaphase Regulation of MECP2 expression and activity EML4 and NUDC in mitotic spindle formation
Drugs			Hesperidin AT9283 Enzastaurin Reversine Fostamatinib TAK-901
Diseases
GWAS			Anxiety disorders ( 31906708) Apolipoprotein A1 levels ( 32203549)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	57 interacting genes: AJUBA ANKZF1 APP BCL2L11 BIRC5 CBX3 CDCA8 CDH1 CENPA CIB1 DCUN1D1 DES EVI5 FBXL2 FLOT1 GANAB GAS2L3 GFAP H3-4 H3C1 H3C14 HASPIN INCENP KLHL13 KLHL21 KLHL9 LATS1 LATS2 LIN28B LNX1 LRRK2 MAPRE1 MAPRE2 MAPRE3 MFHAS1 NCAPH NDC80 NINL NSUN2 NUF2 PKM PSMA3 PTPA RACGAP1 RACK1 RAD52 RASA1 RASSF1 SEPTIN1 SHCBP1 SKA1 SKA3 TACC1 TBL3 TGFBR1 UBE2I USP37
Entrez ID		29127	9212
HPRD ID		05402	05397
Ensembl ID		ENSG00000161800	ENSG00000178999
Uniprot IDs		B2RE34 Q9H0H5	Q96GD4
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K	4AF3
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization	Cell Division Spindle Spindle Organization Cytoskeleton Microtubule Cytoskeleton Organization Spindle Assembly Cytoskeleton Organization Regulation Of Chromosome Separation Microtubule-based Process Regulation Of Cell Cycle Midbody Regulation Of Mitotic Sister Chromatid Separation Chromosome Segregation Microtubule Binding Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Organelle Organization Spindle Midzone Microtubule Cytoskeleton Organization Involved In Mitosis Nuclear Chromosome Segregation Regulation Of Chromosome Segregation Positive Regulation Of Chromosome Segregation Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Positive Regulation Of Chromosome Separation Membraneless Organelle Assembly Regulation Of Sister Chromatid Segregation Regulation Of Cellular Component Organization Chromosome, Centromeric Region Regulation Of Organelle Organization Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Mitotic Nuclear Division Regulation Of Cell Division Chromosome Localization Positive Regulation Of Mitotic Sister Chromatid Separation Regulation Of Cell Cycle Process Microtubule Cytoskeleton Regulation Of Protein-containing Complex Assembly Mitotic Spindle Midzone Assembly Regulation Of Cytokinesis Mitotic Cell Cycle Centrosome Cytoskeleton-dependent Cytokinesis Regulation Of Nuclear Division Mitotic Spindle Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Chromosome Metaphase Chromosome Alignment Spindle Midzone Assembly Spindle Assembly Involved In Female Meiosis Mitotic Cytokinesis
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