RACGAP1 and RND2

Number of citations of the paper that reports this interaction (PubMedID 12590651)
39

Data Source:
HPRD (in vitro, in vivo)

		RACGAP1	RND2
Description		Rac GTPase activating protein 1	Rho family GTPase 2
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Acrosomal Membrane Cytosol Plasma Membrane Membrane Cytoplasmic Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Protein Kinase Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport	Actin Filament Organization Signal Transduction Small GTPase-mediated Signal Transduction Regulation Of Actin Cytoskeleton Organization Collateral Sprouting Positive Regulation Of Collateral Sprouting
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	RND2 GTPase cycle
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	5 interacting genes: FNBP1 MEOX2 RACGAP1 UBXN11 VPS4A
Entrez ID		29127	8153
HPRD ID		05402	03332
Ensembl ID		ENSG00000161800	ENSG00000108830
Uniprot IDs		B2RE34 Q9H0H5	P52198
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization	Spindle Cytoskeleton Flemming Body Cytokinetic Process Microtubule Nucleator Activity Actomyosin Contractile Ring Contraction Late Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Late Endosomal Microautophagy Cytoskeleton-dependent Cytokinesis Regulation Of Cytokinesis Contractile Ring Contraction Positive Regulation Of Viral Budding Via Host ESCRT Complex Centralspindlin Complex Somite Specification Polar Microtubule Mitotic Cytokinesis Checkpoint Signaling Regulation Of Cell Division Midbody Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Actomyosin Contractile Ring Assembly ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Negative Regulation Of Cytokinesis Mitotic Nuclear Membrane Reassembly ESCRT III Complex Disassembly ESCRT Complex Disassembly Mitotic Spindle Midzone Assembly Gamma-tubulin Ring Complex Gamma-tubulin Complex ATPase Complex Sulfate Transmembrane Transport Spindle Midzone Assembly Cytoplasm Segment Specification Somite Development Microtubule Mitotic Spindle Microtubule Lipid Binding Endosomal Vesicle Fusion Viral Budding From Plasma Membrane Negative Regulation Of Cell Division Vacuolar Membrane Positive Regulation Of Exosomal Secretion Late Endosome To Lysosome Transport Regulation Of Exosomal Secretion Meiotic Spindle Organization Pericentriolar Material Intracellular Cholesterol Transport Viral Budding Via Host ESCRT Complex
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