RACGAP1 and RND2

Number of citations of the paper that reports this interaction (PMID 12590651)
3

Data Source:
HPRD (in vivo, in vitro)

		RACGAP1	RND2
Gene Name		Rac GTPase activating protein 1	Rho family GTPase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Acrosomal Membrane Early Endosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	GTPase Activity Protein Binding GTP Binding Protein N-terminus Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Signal Transduction Small GTPase Mediated Signal Transduction Metabolic Process Positive Regulation Of Collateral Sprouting
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	6 interactors: ARHGAP5 FNBP1 MEOX2 RACGAP1 UBXN11 VPS4A
Entrez ID		29127	8153
HPRD ID		05402	03332
Ensembl ID		ENSG00000161800	ENSG00000108830
Uniprot IDs		B2RE34 Q9H0H5	P52198
PDB IDs		2OVJ 4B6D
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Cell Separation After Cytokinesis Regulation Of Cytokinesis Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Cytokinesis Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Abscission Somite Specification Mitotic Spindle Midzone Assembly Viral Budding Via Host ESCRT Complex Regulation Of Cell Division Mitotic Spindle Elongation Mitotic Cytokinetic Process Viral Budding Negative Regulation Of Cytokinesis Spindle Midzone Assembly Mitotic Nuclear Division Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Segment Specification Cell Division Mitotic Spindle Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Virion Assembly Regulation Of Cell Cycle Process Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Mitotic Metaphase Plate Congression Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Metaphase Plate Congression
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	actin actomyosin antagonise atypical bypass contractility cytoskeleton explain extension gtp gtpase hydrolyse inhibiting limit neurite propose reducing regulating regulators relatives rho rhoa rhoe rnd1 rnd3 rock separate smooth thereby
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	actin actomyosin antagonise atypical bypass contractility cytoskeleton explain extension gtp gtpase hydrolyse inhibiting limit neurite propose reducing regulating regulators relatives rho rhoa rhoe rnd1 rnd3 rock separate smooth thereby
Tagcloud (Intersection) ?