RACGAP1 and SLC16A10

Number of citations of the paper that reports this interaction (PMID 11278976)
9

Data Source:
HPRD (in vitro, in vivo)

		RACGAP1	SLC16A10
Gene Name		Rac GTPase activating protein 1	solute carrier family 16 (aromatic amino acid transporter), member 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Plasma Membrane Integral Component Of Membrane Basolateral Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Transporter Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Ion Transport Amino Acid Transport Aromatic Amino Acid Transport Ion Transmembrane Transport Transmembrane Transport
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport
Drugs
Diseases
GWAS			Metabolic traits ( 21886157) Metabolite levels ( 22286219)
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	1 interactors: RACGAP1
Entrez ID		29127	117247
HPRD ID		05402	09613
Ensembl ID		ENSG00000161800	ENSG00000112394
Uniprot IDs		B2RE34 Q9H0H5	Q8TF71
PDB IDs		2OVJ 4B6D
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Mitotic Spindle Midzone Assembly Mitotic Spindle Elongation Mitotic Cytokinetic Process Spindle Midzone Assembly Cell Separation After Cytokinesis Mitotic Spindle Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cytokinesis Sulfate Transport Mitotic Spindle Organization Mitotic Cytokinesis Neuroblast Proliferation Regulation Of Cytokinesis Stem Cell Proliferation Regulation Of Chromosome Segregation Spindle Assembly Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Neural Precursor Cell Proliferation Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Cytokinesis Actomyosin Structure Organization Spindle Organization Positive Regulation Of Cell Division Regulation Of Microtubule Cytoskeleton Organization Regulation Of Microtubule-based Process Positive Regulation Of Cell Cycle Process Antigen Processing And Presentation Of Peptide Antigen Regulation Of Cell Division Inorganic Anion Transport Positive Regulation Of Cell Cycle Antigen Processing And Presentation Microtubule-based Movement Mitotic Nuclear Division Cellular Protein Complex Assembly Blood Coagulation Cell Division Hemostasis Microtubule Cytoskeleton Organization Organelle Assembly Regulation Of Cell Cycle Process Regulation Of Cytoskeleton Organization Spermatogenesis Male Gamete Generation
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	4f2hc aaas aas aminoaciduria antiporter aromatic basolateral compensatory enterocytes equilibrate everted gross grow gut instance intestine intravenously lat2 myocytes phe presumably reproduce sac sink slc7a8 tat1 transported tubule uniporter
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	4f2hc aaas aas aminoaciduria antiporter aromatic basolateral compensatory enterocytes equilibrate everted gross grow gut instance intestine intravenously lat2 myocytes phe presumably reproduce sac sink slc7a8 tat1 transported tubule uniporter
Tagcloud (Intersection) ?