RACGAP1 and VAV1

Number of citations of the paper that reports this interaction (PubMedID 10748082)
0

Data Source:
HPRD (in vivo)

		RACGAP1	VAV1
Description		Rac GTPase activating protein 1	vav guanine nucleotide exchange factor 1
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Phosphotyrosine Residue Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Phosphorylation-dependent Protein Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport	Immune Response-regulating Cell Surface Receptor Signaling Pathway Phagocytosis Immune Response G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Small GTPase-mediated Signal Transduction Regulation Of Cell Size Response To Xenobiotic Stimulus Cell Migration Natural Killer Cell Activation Platelet Activation T Cell Differentiation Neutrophil Chemotaxis T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis B Cell Proliferation T Cell Activation Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Cell Adhesion Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Xenobiotic Stimulus Reactive Oxygen Species Metabolic Process
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	GPVI-mediated activation cascade GPVI-mediated activation cascade PIP3 activates AKT signaling Signaling by SCF-KIT NRAGE signals death through JNK Regulation of actin dynamics for phagocytic cup formation Constitutive Signaling by Aberrant PI3K in Cancer FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 dependent Vav1 pathway G alpha (12/13) signalling events VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling VEGFR2 mediated vascular permeability PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Erythropoietin activates RAS Erythropoietin activates RAS Regulation of signaling by CBL FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis Potential therapeutics for SARS Azathioprine ADME Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS			Blood protein levels ( 30072576) Lymphocyte count ( 32888494) Mean platelet volume ( 27863252 32888494) Periodontitis ( 23459936) Platelet count ( 32888494) Platelet distribution width ( 27863252 32888494)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	80 interacting genes: ABL1 ACTA1 AOC3 AR ARHGDIA ARHGDIB BCR BLNK BTK CASP3 CBL CBLB CD19 CDC42 CFTR CRK CXCR4 DNM2 DOCK2 DOK1 EGFR EMD EPOR ERBB2 ERBB3 ERBB4 EZH2 FGFR1 FYN GAB1 GRB2 HCK HNRNPK HRAS IL6ST INSR JAK2 JUN KHDRBS1 LAT LCK LCP2 MAPK1 MERTK MET NEK3 PAG1 PDGFRB PHAX PIK3R1 PLCG1 PRKCQ PRLR PTK2B PTPN22 PTPN6 RAC1 RACGAP1 RAF1 RHOA RHOG S100B SH3BP2 SHB SHC1 SIAH1 SIAH2 SLA SOCS1 SYK TEC TUBA1A TUBA4A TUBB TYK2 XRCC5 XRCC6 ZAP70 ZNF655 ZYX
Entrez ID		29127	7409
HPRD ID		05402	01284
Ensembl ID		ENSG00000161800	ENSG00000141968
Uniprot IDs		B2RE34 Q9H0H5	A0A0A0MR07 B2R8B5 P15498 Q96D37
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K	2CRH 2LCT 2MC1 2ROR 3BJI 3KY9 6NEW 6NF1 6NFA
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization	Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Signal Transduction Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Antigen Receptor-mediated Signaling Pathway Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Immune System Process T Cell Receptor Signaling Pathway Regulation Of Multicellular Organismal Process Immune System Process Regulation Of Immune System Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Lymphocyte Activation Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of Cell Population Proliferation Cellular Developmental Process Regulation Of Cell Activation Intracellular Signaling Cassette Activation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Immune Response Cell Differentiation Protein Phosphorylation Positive Regulation Of MAPK Cascade Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Cell Adhesion Regulation Of Immune Response Phosphorylation Leukocyte Activation Protein Kinase Activity Regulation Of T Cell Activation Lymphocyte Activation Regulation Of Programmed Cell Death Developmental Process Positive Regulation Of Protein Phosphorylation Nucleotide Binding Regulation Of Apoptotic Process
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