RACGAP1 and KIF23

Number of citations of the paper that reports this interaction (PMID 22939629)
44

Data Source:
BioGRID (biochemical)
HPRD (in vivo)

		RACGAP1	KIF23
Gene Name		Rac GTPase activating protein 1	kinesin family member 23
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Intercellular Bridge Mitotic Spindle Centralspindlin Complex
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Mitotic Spindle Elongation Mitotic Cell Cycle Mitotic Cytokinesis Cytokinesis Microtubule-based Movement Blood Coagulation Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Mitotic Telophase/Cytokinesis MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Cell Cycle, Mitotic M Phase Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	8 interactors: ACTA1 ARF3 PLK1 RACGAP1 USP8 YWHAB YWHAG YWHAQ
Entrez ID		29127	9493
HPRD ID		05402	05455
Ensembl ID		ENSG00000161800	ENSG00000137807
Uniprot IDs		B2RE34 Q9H0H5	Q02241
PDB IDs		2OVJ 4B6D	3VHX
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Mitotic Cytokinesis Small GTPase Mediated Signal Transduction Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Regulation Of Organelle Organization Cytokinesis Positive Regulation Of Organelle Organization Intracellular Signal Transduction Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cellular Response To Stimulus Mitotic Cell Cycle Process Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Mitotic Cell Cycle Regulation Of Protein Localization Membrane Organization Protein Localization Apoptotic Signaling Pathway Regulation Of Cellular Component Organization Response To Stimulus Regulation Of Cellular Localization Cell Cycle Process Protein Targeting Cell Division Regulation Of Intracellular Transport Regulation Of Chromosome Segregation Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Cell Cycle Cellular Protein Localization Actomyosin Structure Organization Skeletal Muscle Fiber Adaptation Activation Of APC-Cdc20 Complex Activity G2/M Transition Of Mitotic Cell Cycle Protein Transport Positive Regulation Of Apoptotic Process Positive Regulation Of Cell Division Positive Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Cell Death Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Cell Death Regulation Of Establishment Of Protein Localization Polar Body Extrusion After Meiotic Divisions Cell Proliferation Positive Regulation Of Transport
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	alveolar astrocyte causing challenges col6a3 comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 lox lymphocyte lymphocytic methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	alveolar astrocyte causing challenges col6a3 comparisons counting cpg cut epigenetic gbm gdna germ glioblastoma htb k27 lox lymphocyte methylation methyltransferase modifications mscc multiforme pbk percentages possessed regard summarized
Tagcloud (Intersection) ?		lymphocytic