RACGAP1 and TUBG1

Number of citations of the paper that reports this interaction (PMID 11942621)
6

Data Source:
HPRD (in vivo)

		RACGAP1	TUBG1
Gene Name		Rac GTPase activating protein 1	tubulin, gamma 1
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Pericentriolar Material Condensed Nuclear Chromosome Gamma-tubulin Complex Cytoplasm Centrosome Centriole Polar Microtubule Cytosol Cytoplasmic Microtubule Cell Leading Edge Nonmotile Primary Cilium Ciliary Basal Body Apical Part Of Cell Recycling Endosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	G2/M Transition Of Mitotic Cell Cycle Meiotic Spindle Organization Microtubule Cytoskeleton Organization Mitotic Cell Cycle Organelle Organization Microtubule Nucleation Cytoplasmic Microtubule Organization
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Organelle biogenesis and maintenance Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Recruitment of NuMA to mitotic centrosomes Cell Cycle, Mitotic Loss of proteins required for interphase microtubule organizationÂ from the centrosome Loss of Nlp from mitotic centrosomes Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	24 interactors: BRCA1 CENPJ CNTN2 IKBKG KRT18 KRT19 MARK4 NAPG NDE1 OLA1 PCNT PIK3R1 PLK1 PXN RACGAP1 RASSF1 RNF19A RPGR SPATC1 TUBA1B TUBA3C TUBB4B TUBGCP3 TUBGCP4
Entrez ID		29127	7283
HPRD ID		05402	01853
Ensembl ID		ENSG00000161800	ENSG00000131462
Uniprot IDs		B2RE34 Q9H0H5	P23258
PDB IDs		2OVJ 4B6D	1Z5V 1Z5W 3CB2
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Microtubule-based Process Microtubule Cytoskeleton Organization Cytoskeleton Organization G2/M Transition Of Mitotic Cell Cycle Protein Polymerization Cellular Protein Complex Assembly Organelle Organization Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Cell Cycle Cell Cycle Process Microtubule Nucleation Cellular Component Assembly Cellular Macromolecular Complex Assembly Microtubule Polymerization Mitotic Cell Cycle Process Protein Complex Assembly Mitotic Cell Cycle Microtubule Polymerization Or Depolymerization Centrosome Organization Microtubule Organizing Center Organization Organelle Assembly Regulation Of Protein Stability Centrosome Cycle 'de Novo' Posttranslational Protein Folding 'de Novo' Protein Folding Cell Division Movement Of Cell Or Subcellular Component Regulation Of Centriole Replication Regulation Of Cell Cycle Process Protein Stabilization Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Cellular Localization Negative Regulation Of Cell Death Spindle Organization Growth Hormone Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Cellular Response To Growth Hormone Stimulus Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule Cytoskeleton Organization Regulation Of Cell Death Centrosome Duplication G2 DNA Damage Checkpoint Neuron Migration Regulation Of Microtubule-based Process Response To Growth Hormone Regulation Of Centrosome Duplication Positive Regulation Of Protein Metabolic Process
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	bipolar dcx disorganization dync1h1 electroporation ganglial gyral inputs interchangeability kif2a kif5c malformations mcd mcds polarization polymicrogyria postmitotic radial rescue round stereotyped tbr2 tuba1a tubb2b tubb3 tubb5 tubulin tubulins utero
Tagcloud (Intersection) ?