RACGAP1 and PPP2CA

Number of citations of the paper that reports this interaction (PMID 18201571)
12

Data Source:
HPRD (in vitro)

		RACGAP1	PPP2CA
Gene Name		Rac GTPase activating protein 1	protein phosphatase 2, catalytic subunit, alpha isozyme
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Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Protein Phosphatase Type 2A Complex Chromosome, Centromeric Region Spindle Pole Nucleus Mitochondrion Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Extracellular Vesicular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Protein Serine/threonine Phosphatase Activity Protein Binding Protein C-terminus Binding Metal Ion Binding Protein Dimerization Activity GABA Receptor Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Inactivation Of MAPK Activity Mitotic Cell Cycle Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Dephosphorylation Ceramide Metabolic Process Apoptotic Process Mitotic Nuclear Envelope Reassembly Mesoderm Development RNA Splicing Fibroblast Growth Factor Receptor Signaling Pathway Response To Organic Substance Gene Expression Regulation Of Receptor Activity Negative Regulation Of Epithelial To Mesenchymal Transition Second-messenger-mediated Signaling Regulation Of Wnt Signaling Pathway Regulation Of Cell Adhesion Negative Regulation Of Cell Growth Regulation Of Protein Autophosphorylation Regulation Of Growth Regulation Of Protein Catabolic Process Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cell Differentiation Meiotic Cell Cycle Protein Heterotrimerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Signaling by GPCR Integration of energy metabolism Signaling by FGFR in disease Mitotic Prophase misspliced GSK3beta mutants stabilize beta-catenin T41 mutants of beta-catenin aren't phosphorylated ERKs are inactivated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Glycolysis Signaling by Wnt Glucose metabolism Toll Like Receptor TLR1:TLR2 Cascade Degradation of beta-catenin by the destruction complex Toll Like Receptor 5 (TLR5) Cascade RNF mutants show enhanced WNT signaling and proliferation Myoclonic epilepsy of Lafora S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling G1/S Transition Glycogen storage diseases MyD88 dependent cascade initiated on endosome Toll Like Receptor 9 (TLR9) Cascade Beta-catenin phosphorylation cascade Initiation of Nuclear Envelope Reformation Mitotic G1-G1/S phases ERK/MAPK targets Negative regulation of FGFR signaling truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TRIF-mediated TLR3/TLR4 signaling Opioid Signalling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Spry regulation of FGF signaling Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Toll Like Receptor 2 (TLR2) Cascade Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion Toll Like Receptor 3 (TLR3) Cascade Toll Like Receptor 4 (TLR4) Cascade Metabolism of carbohydrates Mitotic G2-G2/M phases Mitotic Metaphase and Anaphase Adaptive Immune System PP2A-mediated dephosphorylation of key metabolic factors MASTL Facilitates Mitotic Progression Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids APC truncation mutants have impaired AXIN binding Toll Like Receptor 7/8 (TLR7/8) Cascade G2/M Transition Mitotic Anaphase M Phase Toll Like Receptor TLR6:TLR2 Cascade APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Activated TLR4 signalling S37 mutants of beta-catenin aren't phosphorylated MyD88 cascade initiated on plasma membrane Cyclin A/B1 associated events during G2/M transition XAV939 inhibits tankyrase, stabilizing AXIN DARPP-32 events MyD88:Mal cascade initiated on plasma membrane TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation Nuclear Envelope Reassembly Innate Immune System Nonsense-Mediated Decay (NMD) E2F mediated regulation of DNA replication ERKs are inactivated Signalling by NGF MAP kinase activation in TLR cascade CTLA4 inhibitory signaling G1 Phase NGF signalling via TRKA from the plasma membrane MyD88-independent cascade Cell Cycle, Mitotic Signaling by FGFR Toll-Like Receptors Cascades Cyclin D associated events in G1 Toll Like Receptor 10 (TLR10) Cascade TCF dependent signaling in response to WNT ERK/MAPK targets deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling MAPK targets/ Nuclear events mediated by MAP kinases Signaling by WNT in cancer Inhibition of replication initiation of damaged DNA by RB1/E2F1 Nuclear Events (kinase and transcription factor activation)
Drugs
Diseases
GWAS
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	71 interactors: ADCY8 AKT1 APC AXIN1 BCL2 BEST1 BMPR1B CAD CAV1 CCNG1 CCNG2 CDK2 CDK6 CDKN2C CHEK2 CXCR2 DVL3 EEF2 EIF4EBP1 ETF1 FCAR GABRB3 GAD1 GOLGA2 HTT IGBP1 ISYNA1 JAK2 MAPK1 MAPK3 MAPT MID1 MRPS26 MYH9 NME2 NXN PACS1 PPP1CA PPP2R1A PPP2R1B PPP2R2A PPP2R3A PPP2R3B PPP2R5B PPP2R5C PPP2R5E PRKAA1 PRKCD PTN PXN RACGAP1 RBL2 RELA RHO RHOB RPS6KB1 RRAS SET SGK1 SGOL1 SGOL2 STAT5A STAT5B STRN TLX1 TP53 TRIP13 TSC2 VAC14 VDR XRN1
Entrez ID		29127	5515
HPRD ID		05402	08912
Ensembl ID		ENSG00000161800
Uniprot IDs		B2RE34 Q9H0H5	B3KUN1 P67775
PDB IDs		2OVJ 4B6D	2IAE 2IE3 2IE4 2NPP 2NYL 2NYM 3C5W 3DW8 3FGA 3K7V 3K7W 3P71 4I5L 4I5N 4IYP
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Cell Cycle Mitotic Cell Cycle Regulation Of Catalytic Activity Cell Cycle Process Signal Transduction Cellular Response To Stimulus Regulation Of Protein Metabolic Process Signaling Cell Communication Regulation Of Cell Cycle Regulation Of Apoptotic Process Regulation Of Cell Proliferation Regulation Of Cell Death Enzyme Linked Receptor Protein Signaling Pathway Response To Stimulus Regulation Of Phosphorylation Response To Organonitrogen Compound Regulation Of Phosphorus Metabolic Process Apoptotic Process Developmental Process Regulation Of Metabolic Process Response To Organic Substance Programmed Cell Death Mitotic Cell Cycle Process Regulation Of Kinase Activity Cellular Response To Organic Substance Anatomical Structure Development Cell Surface Receptor Signaling Pathway Cell Death Death Regulation Of Cellular Protein Metabolic Process System Development Cellular Response To Organonitrogen Compound Cellular Response To Peptide Hormone Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Organ Development Multicellular Organismal Development Negative Regulation Of Programmed Cell Death Cellular Response To Peptide Response To Hormone Regulation Of MAPK Cascade Positive Regulation Of Protein Metabolic Process Cellular Response To Stress Negative Regulation Of Cell Death Regulation Of Protein Kinase Activity Intracellular Signal Transduction Regulation Of Signal Transduction Positive Regulation Of Signal Transduction
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?