RACGAP1 and SLC26A8

Number of citations of the paper that reports this interaction (PubMedID 11278976)
0

Data Source:
HPRD (two hybrid, in vitro)

		RACGAP1	SLC26A8
Description		Rac GTPase activating protein 1	solute carrier family 26 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Plasma Membrane Membrane Sperm Annulus
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Chloride Channel Activity Protein Binding Sulfate Transmembrane Transporter Activity Antiporter Activity Oxalate Transmembrane Transporter Activity Chloride:bicarbonate Antiporter Activity Sulfate:chloride Antiporter Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport	Monoatomic Ion Transport Chloride Transport Spermatogenesis Oxalate Transport Cell Differentiation Meiotic Cell Cycle Transmembrane Transport Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins
Drugs
Diseases
GWAS			Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Appendicular lean mass ( 33097823) Femur bone mineral density x serum urate levels interaction ( 34046847)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	1 interacting genes: RACGAP1
Entrez ID		29127	116369
HPRD ID		05402	12241
Ensembl ID		ENSG00000161800	ENSG00000112053
Uniprot IDs		B2RE34 Q9H0H5	Q96RN1
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization	Ribonucleotide Binding Centralspindlin Complex Actomyosin Contractile Ring Assembly Alpha DNA Polymerase:primase Complex DNA Replication, Synthesis Of Primer Mitotic Spindle Midzone Assembly Sulfate Transmembrane Transport Spindle Midzone Assembly DNA Replication Initiation DNA-directed RNA Polymerase Activity DNA-directed RNA Polymerase Complex Cortical Actin Cytoskeleton Organization Flemming Body Regulation Of Attachment Of Spindle Microtubules To Kinetochore Alpha-tubulin Binding Neuroblast Proliferation Cortical Cytoskeleton Organization Phosphatidylinositol-3,4,5-trisphosphate Binding Gamma-tubulin Binding Positive Regulation Of Cytokinesis Beta-tubulin Binding Cytokinetic Process Spindle Midzone Cleavage Furrow Mitotic Cytokinesis Rho Protein Signal Transduction Erythrocyte Differentiation Nucleotidyltransferase Activity Positive Regulation Of Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Cytokinesis Neural Precursor Cell Proliferation Regulation Of Embryonic Development Zinc Ion Binding Cytoplasmic Side Of Plasma Membrane Actomyosin Structure Organization Acrosomal Vesicle Inorganic Anion Transmembrane Transport Inorganic Anion Transport Mitotic Spindle
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