RACGAP1 and CHN2

Number of citations of the paper that reports this interaction (PMID 11278894)
16

Data Source:
HPRD (in vitro)

		RACGAP1	CHN2
Gene Name		Rac GTPase activating protein 1	chimerin 2
Image
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Cytosol Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	SH3/SH2 Adaptor Activity GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Small GTPase Mediated Signal Transduction Positive Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Rho GTPase cycle Signaling by Rho GTPases
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	6 interactors: AKT1 BAG6 ERBB3 RAC1 RACGAP1 TGFBR1
Entrez ID		29127	1124
HPRD ID		05402	04173
Ensembl ID		ENSG00000161800	ENSG00000106069
Uniprot IDs		B2RE34 Q9H0H5	A4D1A2 B3VCF5 B3VCG4 B7Z1V0 P52757
PDB IDs		2OVJ 4B6D	1XA6
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Wound Healing Response To Wounding Intracellular Signal Transduction Immune System Process Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Nervous System Development Cell Death Death Embryo Development Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Regulation Of Apoptotic Process Response To Growth Factor Positive Regulation Of Catalytic Activity Regulation Of Cell Death Gamete Generation Cell Differentiation Neurogenesis Response To Stress Positive Regulation Of Protein Phosphorylation Regulation Of Intracellular Signal Transduction Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Kinase Activity Sexual Reproduction Multicellular Organismal Reproductive Process Multicellular Organism Reproduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Enzyme Linked Receptor Protein Signaling Pathway Fc Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Protein Modification Process System Development Negative Regulation Of Programmed Cell Death Peptidyl-amino Acid Modification Regulation Of Protein Metabolic Process Negative Regulation Of Cell Death Reproduction Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Catalytic Activity Positive Regulation Of Cellular Component Movement Multicellular Organismal Development Positive Regulation Of Cellular Protein Metabolic Process Immune Response-regulating Cell Surface Receptor Signaling Pathway
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent	ala antibody bound cbz cysteine degraded dense endocytosis enzymes exchange exposing fibroblasts former lysosomal lysosomes mannose newly normally phe polyclonal polypeptides precursors proteinases recovered segregation smaller spared tagged transported
Tagcloud (Intersection) ?