RACGAP1 and CHN2

Number of citations of the paper that reports this interaction (PubMedID 11278894)
0

Data Source:
HPRD (in vitro)

		RACGAP1	CHN2
Description		Rac GTPase activating protein 1	chimerin 2
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytoplasm Mitochondrion Spindle Cytosol Cytoskeleton Microtubule Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Midbody Cytoplasmic Vesicle Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Cytosol Membrane Synapse
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Zinc Ion Binding Lipid Binding Protein Kinase Binding Protein-macromolecule Adaptor Activity Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	GTPase Activator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Monoatomic Ion Transport Signal Transduction Rho Protein Signal Transduction Spermatogenesis Neuroblast Proliferation Cell Differentiation Erythrocyte Differentiation Positive Regulation Of Cytokinesis Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Cell Division Regulation Of Attachment Of Spindle Microtubules To Kinetochore Sulfate Transmembrane Transport	Acrosome Assembly Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RAC3 GTPase cycle Kinesins	RAC1 GTPase cycle
Drugs
Diseases
GWAS			Circulating leptin levels in high cardiovascular risk ( 31766143) CSF tryptophan concentration in tuberculous meningitis ( 29395996) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Facial emotion recognition ( 28608620) Facial emotion recognition (angry faces) ( 28608620) Facial emotion recognition (sad faces) ( 28608620) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Loneliness (linear analysis) ( 27629369) Methadone dose in opioid dependence ( 28115739) Obesity-related traits ( 23251661) Psychosis (atypical) ( 24132900) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	14 interacting genes: ANKK1 BAG6 ERBB3 NCK1 NCK2 RAC1 RACGAP1 RANBP3 RB1 SENP8 SHF SMARCD1 TGFBR1 TP53RK
Entrez ID		29127	1124
HPRD ID		05402	04173
Ensembl ID		ENSG00000161800	ENSG00000106069
Uniprot IDs		B2RE34 Q9H0H5	A0A2X0TVW3 A0A994J7L4 B3VCF4 B3VCF5 B3VCF6 B3VCF9 B7Z1V0 B7Z1W9 B7Z215 P52757
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K	1XA6
Enriched GO Terms of Interacting Partners?		Spindle Microtubule Intracellular Signal Transduction Spindle Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly Midbody Spindle Midzone Assembly Protein Phosphatase Type 2A Complex Mitotic Spindle Elongation Microtubule Cytoskeleton Organization Involved In Mitosis Nucleotide Binding Mitotic Cell Cycle Signal Transduction Mitotic Cytokinesis Microtubule Cytoskeleton Regulation Of Protein Localization To Nucleus Regulation Of Attachment Of Spindle Microtubules To Kinetochore Centralspindlin Complex Microtubule-based Process Cytosol Microtubule Cytoskeleton Organization Cell Division Regulation Of Cell Division Regulation Of Protein Modification Process Cytoskeleton-dependent Cytokinesis Mitotic Spindle Organization Spindle Elongation Cytoskeleton Protein Serine Kinase Activity Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Process Positive Regulation Of Protein Modification Process MAPK Cascade Regulation Of Cell Cycle G2/M Phase Transition Positive Regulation Of Cytokinesis Regulation Of Phosphorus Metabolic Process Protein Serine/threonine Kinase Activity Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle Positive Regulation Of Mitotic Sister Chromatid Segregation Intracellular Signaling Cassette Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Regulation Of Intracellular Signal Transduction Phosphorylation-dependent Protein Binding Cell Cycle G2/M Phase Transition Protein Kinase Binding Mitotic Nuclear Membrane Disassembly Mitotic Spindle Midzone Regulation Of Protein Import Into Nucleus Regulation Of Protein Localization	Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Positive Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Lamellipodium Organization Positive Regulation Of Translation In Response To Stress Positive Regulation Of Cytoskeleton Organization Signal Complex Assembly Regulation Of Multicellular Organismal Process Regulation Of Translation In Response To Endoplasmic Reticulum Stress Regulation Of Translational Initiation In Response To Stress Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Protein Polymerization Positive Regulation Of Organelle Organization Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Actin Filament Organization Regulation Of PERK-mediated Unfolded Protein Response Cell Surface Receptor Signaling Pathway Ubiquitin Protein Ligase Binding Positive Regulation Of Immune System Process Regulation Of Actin Filament Polymerization Cytoskeletal Anchor Activity Regulation Of Translation In Response To Stress Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Cell Morphogenesis Involved In Neuron Differentiation Cell Activation Regulation Of Actin Cytoskeleton Organization Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Cell Projection Assembly Regulation Of Actin Filament-based Process Regulation Of Actin Filament Length Positive Regulation Of Extracellular Matrix Organization Regulation Of Supramolecular Fiber Organization Signaling Receptor Binding Regulation Of Apoptotic Signaling Pathway Regulation Of Organelle Organization SWI/SNF Complex Positive Regulation Of Gene Expression Signaling Receptor Complex Adaptor Activity Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Adhesion
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