Wiki-Pi
Answer Survey
Home
About
Help
Advanced Search
RACGAP1 and PPP2R5E
Number of citations of the paper that reports this interaction (PMID
18201571
)
12
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
RACGAP1
PPP2R5E
Gene Name
Rac GTPase activating protein 1
protein phosphatase 2, regulatory subunit B, epsilon isoform
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Acrosomal Vesicle
Nucleus
Nucleoplasm
Cytosol
Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Cleavage Furrow
Spindle Midzone
Extracellular Vesicular Exosome
Mitotic Spindle
Centralspindlin Complex
Protein Phosphatase Type 2A Complex
Cytoplasm
Molecular Function
GTPase Activator Activity
Protein Binding
Phosphatidylinositol-3,4,5-trisphosphate Binding
Microtubule Binding
Protein Kinase Binding
Alpha-tubulin Binding
Gamma-tubulin Binding
Metal Ion Binding
Beta-tubulin Binding
Protein Binding
Protein Phosphatase Type 2A Regulator Activity
Biological Process
Mitotic Cytokinesis
Actomyosin Contractile Ring Assembly
Microtubule-based Movement
Cytokinesis, Initiation Of Separation
Small GTPase Mediated Signal Transduction
Spermatogenesis
Neuroblast Proliferation
Blood Coagulation
Sulfate Transport
Embryo Development
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Positive Regulation Of Cytokinesis
Positive Regulation Of GTPase Activity
Regulation Of Small GTPase Mediated Signal Transduction
Mitotic Spindle Midzone Assembly
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Signal Transduction
Regulation Of Catalytic Activity
Pathways
Rho GTPase cycle
Signaling by Rho GTPases
MHC class II antigen presentation
Kinesins
Factors involved in megakaryocyte development and platelet production
Adaptive Immune System
Mitotic Prometaphase
Costimulation by the CD28 family
Separation of Sister Chromatids
misspliced GSK3beta mutants stabilize beta-catenin
APC truncation mutants have impaired AXIN binding
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Mitotic Anaphase
Signaling by Wnt
M Phase
APC truncation mutants are not K63 polyubiquitinated
disassembly of the destruction complex and recruitment of AXIN to the membrane
Degradation of beta-catenin by the destruction complex
S37 mutants of beta-catenin aren't phosphorylated
RNF mutants show enhanced WNT signaling and proliferation
S33 mutants of beta-catenin aren't phosphorylated
AXIN mutants destabilize the destruction complex, activating WNT signaling
XAV939 inhibits tankyrase, stabilizing AXIN
Beta-catenin phosphorylation cascade
truncations of AMER1 destabilize the destruction complex
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling
CTLA4 inhibitory signaling
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Cell Cycle, Mitotic
Platelet homeostasis
deletions in the AMER1 gene destabilize the destruction complex
TCF dependent signaling in response to WNT
Platelet sensitization by LDL
AMER1 mutants destabilize the destruction complex
Resolution of Sister Chromatid Cohesion
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Signaling by WNT in cancer
Mitotic Metaphase and Anaphase
Adaptive Immune System
Drugs
Diseases
GWAS
Response to antineoplastic agents (
21659360
)
Protein-Protein Interactions
26 interactors:
AURKB
CDK1
CHN2
ECT2
KIF23
MAP3K10
MAP3K4
MORF4L1
MPRIP
NRAS
PPP2CA
PPP2R4
PPP2R5E
PRC1
PRSS23
RND2
SH3RF1
SLC16A10
SLC26A8
TANK
TUBA4A
TUBG1
TXNDC11
VAV1
YWHAB
YWHAG
8 interactors:
APP
BHLHB9
CHEK2
PPP2CA
PPP2R1B
RACGAP1
SGOL1
SMAD9
Entrez ID
29127
5529
HPRD ID
05402
09040
Ensembl ID
ENSG00000161800
Uniprot IDs
B2RE34
Q9H0H5
B7Z5X1
B7Z7C0
B7ZAW5
B7ZKK9
J3KQN6
Q16537
Q59EK0
PDB IDs
2OVJ
4B6D
Enriched GO Terms of Interacting Partners
?
Activation Of MAPKK Activity
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Cell Cycle
Cell Cycle Process
Mitotic Spindle Elongation
Intracellular Signal Transduction
Mitotic Spindle Organization
Regulation Of Catalytic Activity
Spindle Organization
Microtubule Cytoskeleton Organization
Activation Of Protein Kinase Activity
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Kinase Activity
Regulation Of Protein Kinase Activity
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Kinase Activity
Regulation Of Apoptotic Process
Regulation Of Phosphorus Metabolic Process
Positive Regulation Of Transferase Activity
Positive Regulation Of Catalytic Activity
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Regulation Of Cell Death
Regulation Of MAPK Cascade
Small GTPase Mediated Signal Transduction
Positive Regulation Of Protein Modification Process
Neurotrophin TRK Receptor Signaling Pathway
Neurotrophin Signaling Pathway
Cytokinesis
MAPK Cascade
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Regulation Of Phosphorylation
Apoptotic Process
Regulation Of Intracellular Signal Transduction
Programmed Cell Death
Protein Complex Assembly
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Cytokinesis
Regulation Of Signal Transduction
G2/M Transition Of Mitotic Cell Cycle
Cell Death
Death
Regulation Of Protein Phosphorylation
Microtubule-based Process
Signal Transduction By Phosphorylation
Positive Regulation Of Cellular Protein Metabolic Process
Cytoskeleton Organization
Regulation Of Cellular Protein Metabolic Process
Negative Regulation Of Protein Dephosphorylation
Mitotic Spindle Assembly
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Microtubule-based Process
Mitotic Spindle Organization
Mitotic Nuclear Division
Apoptotic Process
Programmed Cell Death
Cell Cycle Process
Reproduction
Developmental Process
Cell Death
Death
Cell Division
Spindle Assembly
Microtubule Cytoskeleton Organization
Signal Transduction Involved In Intra-S DNA Damage Checkpoint
Cytokinesis, Initiation Of Separation
Actomyosin Contractile Ring Assembly
Regulation Of Synapse Structure Or Activity
Regulation Of Cell Cycle Process
Cell Cycle
Synaptic Growth At Neuromuscular Junction
Regulation Of Receptor Activity
Regulation Of DNA Replication
Spindle Organization
Collateral Sprouting In Absence Of Injury
Regulation Of Cell Differentiation
Anatomical Structure Development
Collateral Sprouting
Axon Midline Choice Point Recognition
Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Centriole-centriole Cohesion
Intracellular Signal Transduction
Meiotic Cell Cycle
Regulation Of Peptidyl-tyrosine Phosphorylation
Cellular Component Assembly
Axon Choice Point Recognition
Mitotic Spindle Midzone Assembly
Regulation Of Cell Development
Positive Regulation Of Metabolic Process
Positive Regulation Of Cell Cycle Process
Mitotic Spindle Elongation
Mitotic Cytokinetic Process
Mullerian Duct Regression
Regulation Of Cell Cycle Phase Transition
Regulation Of Cell Cycle
Neuron Remodeling
Mitotic Nuclear Envelope Reassembly
Tagcloud
?
anapc1
antagonizes
canonical
cd40l
cdk6
chip
combine
consequence
crosstalk
dek
ezh2
ikkalpha
involves
kappab2
lymphocytic
microenvironment
nemo
nik
p100
p21waf1
p52
polycomb
psma5
rel
rela
relb
retinoblastoma
route
senescent
Tagcloud (Difference)
?
anapc1
antagonizes
canonical
cd40l
cdk6
chip
combine
consequence
crosstalk
dek
ezh2
ikkalpha
involves
kappab2
lymphocytic
microenvironment
nemo
nik
p100
p21waf1
p52
polycomb
psma5
rel
rela
relb
retinoblastoma
route
senescent
Tagcloud (Intersection)
?