RACGAP1 and PPP2R5E

Number of citations of the paper that reports this interaction (PMID 18201571)
12

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		RACGAP1	PPP2R5E
Gene Name		Rac GTPase activating protein 1	protein phosphatase 2, regulatory subunit B, epsilon isoform
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Vesicular Exosome Mitotic Spindle Centralspindlin Complex	Protein Phosphatase Type 2A Complex Cytoplasm
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Protein Binding Protein Phosphatase Type 2A Regulator Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Microtubule-based Movement Cytokinesis, Initiation Of Separation Small GTPase Mediated Signal Transduction Spermatogenesis Neuroblast Proliferation Blood Coagulation Sulfate Transport Embryo Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Signal Transduction Regulation Of Catalytic Activity
Pathways		Rho GTPase cycle Signaling by Rho GTPases MHC class II antigen presentation Kinesins Factors involved in megakaryocyte development and platelet production Adaptive Immune System	Mitotic Prometaphase Costimulation by the CD28 family Separation of Sister Chromatids misspliced GSK3beta mutants stabilize beta-catenin APC truncation mutants have impaired AXIN binding T41 mutants of beta-catenin aren't phosphorylated truncated APC mutants destabilize the destruction complex TCF7L2 mutants don't bind CTBP Mitotic Anaphase Signaling by Wnt M Phase APC truncation mutants are not K63 polyubiquitinated disassembly of the destruction complex and recruitment of AXIN to the membrane Degradation of beta-catenin by the destruction complex S37 mutants of beta-catenin aren't phosphorylated RNF mutants show enhanced WNT signaling and proliferation S33 mutants of beta-catenin aren't phosphorylated AXIN mutants destabilize the destruction complex, activating WNT signaling XAV939 inhibits tankyrase, stabilizing AXIN Beta-catenin phosphorylation cascade truncations of AMER1 destabilize the destruction complex misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling CTLA4 inhibitory signaling phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex AXIN missense mutants destabilize the destruction complex S45 mutants of beta-catenin aren't phosphorylated Cell Cycle, Mitotic Platelet homeostasis deletions in the AMER1 gene destabilize the destruction complex TCF dependent signaling in response to WNT Platelet sensitization by LDL AMER1 mutants destabilize the destruction complex Resolution of Sister Chromatid Cohesion deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling Signaling by WNT in cancer Mitotic Metaphase and Anaphase Adaptive Immune System
Drugs
Diseases
GWAS			Response to antineoplastic agents ( 21659360)
Protein-Protein Interactions		26 interactors: AURKB CDK1 CHN2 ECT2 KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PPP2CA PPP2R4 PPP2R5E PRC1 PRSS23 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	8 interactors: APP BHLHB9 CHEK2 PPP2CA PPP2R1B RACGAP1 SGOL1 SMAD9
Entrez ID		29127	5529
HPRD ID		05402	09040
Ensembl ID		ENSG00000161800
Uniprot IDs		B2RE34 Q9H0H5	B7Z5X1 B7Z7C0 B7ZAW5 B7ZKK9 J3KQN6 Q16537 Q59EK0
PDB IDs		2OVJ 4B6D
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Mitotic Cell Cycle Process Mitotic Cell Cycle Cell Cycle Cell Cycle Process Mitotic Spindle Elongation Intracellular Signal Transduction Mitotic Spindle Organization Regulation Of Catalytic Activity Spindle Organization Microtubule Cytoskeleton Organization Activation Of Protein Kinase Activity Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Regulation Of Protein Kinase Activity Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Kinase Activity Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Transferase Activity Positive Regulation Of Catalytic Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Regulation Of Cell Death Regulation Of MAPK Cascade Small GTPase Mediated Signal Transduction Positive Regulation Of Protein Modification Process Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Cytokinesis MAPK Cascade Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation Apoptotic Process Regulation Of Intracellular Signal Transduction Programmed Cell Death Protein Complex Assembly Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokinesis Regulation Of Signal Transduction G2/M Transition Of Mitotic Cell Cycle Cell Death Death Regulation Of Protein Phosphorylation Microtubule-based Process Signal Transduction By Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Dephosphorylation	Mitotic Spindle Assembly Mitotic Cell Cycle Process Mitotic Cell Cycle Microtubule-based Process Mitotic Spindle Organization Mitotic Nuclear Division Apoptotic Process Programmed Cell Death Cell Cycle Process Reproduction Developmental Process Cell Death Death Cell Division Spindle Assembly Microtubule Cytoskeleton Organization Signal Transduction Involved In Intra-S DNA Damage Checkpoint Cytokinesis, Initiation Of Separation Actomyosin Contractile Ring Assembly Regulation Of Synapse Structure Or Activity Regulation Of Cell Cycle Process Cell Cycle Synaptic Growth At Neuromuscular Junction Regulation Of Receptor Activity Regulation Of DNA Replication Spindle Organization Collateral Sprouting In Absence Of Injury Regulation Of Cell Differentiation Anatomical Structure Development Collateral Sprouting Axon Midline Choice Point Recognition Negative Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Centriole-centriole Cohesion Intracellular Signal Transduction Meiotic Cell Cycle Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Component Assembly Axon Choice Point Recognition Mitotic Spindle Midzone Assembly Regulation Of Cell Development Positive Regulation Of Metabolic Process Positive Regulation Of Cell Cycle Process Mitotic Spindle Elongation Mitotic Cytokinetic Process Mullerian Duct Regression Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Neuron Remodeling Mitotic Nuclear Envelope Reassembly
Tagcloud ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent
Tagcloud (Difference) ?		anapc1 antagonizes canonical cd40l cdk6 chip combine consequence crosstalk dek ezh2 ikkalpha involves kappab2 lymphocytic microenvironment nemo nik p100 p21waf1 p52 polycomb psma5 rel rela relb retinoblastoma route senescent
Tagcloud (Intersection) ?