PXN and PAK3

Number of citations of the paper that reports this interaction (PubMedID 11096073)
0

Data Source:
HPRD (in vitro)

		PXN	PAK3
Description		paxillin	p21 (RAC1) activated kinase 3
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse
	Molecular Function	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Cellular Response To Starvation Dendrite Development Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Development Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Regulation Of Actin Filament Organization
Pathways		GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle
Drugs			Fostamatinib
Diseases			Non-syndromic X-linked mental retardation
GWAS		Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN	13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1
Entrez ID		5829	5063
HPRD ID		03937	02142
Ensembl ID		ENSG00000089159	ENSG00000077264
Uniprot IDs		A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023	B2RCU6 O75914
PDB IDs		1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0	6FD3
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway	Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Lamellipodium Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Cell Cortex Lamellipodium Regulation Of Microtubule Polymerization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Postsynapse Cell Junction Organization Cell Projection Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Or Depolymerization Actin Filament Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Lamellipodium Organization Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Substrate Adhesion-dependent Cell Spreading Cell-cell Junction Endocytosis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Signal Complex Assembly Intracellular Signaling Cassette Presynapse Thioesterase Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Regulation Of Neurotransmitter Secretion Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Stress Fiber Assembly
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