PXN and POLR1D

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		PXN	POLR1D
Description		paxillin	RNA polymerase I and III subunit D
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction	DNA-directed RNA Polymerase Complex Nucleus Nucleoplasm RNA Polymerase III Complex Nucleolus RNA Polymerase I Complex Cytosol Nuclear DNA-directed RNA Polymerase Complex
	Molecular Function	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding	DNA Binding DNA-directed RNA Polymerase Activity Protein Binding Protein Dimerization Activity
	Biological Process	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway	DNA-templated Transcription Transcription Elongation By RNA Polymerase I Transcription By RNA Polymerase III
Pathways		GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Cytosolic sensors of pathogen-associated DNA NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase III Chain Elongation RNA Polymerase I Transcription Termination RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 1 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 2 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter
Drugs
Diseases			Treacher Collins syndrome
GWAS		Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)	Body mass index ( 26426971)
Interacting Genes		86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN	15 interacting genes: CDC25A CEBPA CRKL DDIT3 DNAJB4 DNAJB6 E2F4 GRB2 HAX1 MAGEA11 MRPL12 NFKBIB NR3C1 POLR1C PXN
Entrez ID		5829	51082
HPRD ID		03937	17877
Ensembl ID		ENSG00000089159	ENSG00000186184
Uniprot IDs		A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023	A0A087WTY1 P0DPB5 P0DPB6
PDB IDs		1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0	7A6H 7AE1 7AE3 7AEA 7AST 7D58 7D59 7DN3 7DU2 7FJI 7FJJ 7OB9 7OBA 7OBB 7VBA 7VBB 7VBC 8A43 8ITY 8IUE 8IUH 9FSO 9FSP 9FSQ 9FSR 9FSS
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway	CHOP-C/EBP Complex Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription Regulator Complex Regulation Of DNA-templated Transcription Protein Domain Specific Binding Regulation Of RNA Biosynthetic Process Protein-folding Chaperone Binding Transcription By RNA Polymerase I Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process RNA Polymerase II Transcription Regulator Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Gene Expression ATPase Activator Activity Nucleoplasm Cytoplasm Regulation Of Primary Metabolic Process DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Cortex Integrated Stress Response Signaling RNA Polymerase II-specific DNA-binding Transcription Factor Binding Response To Dexamethasone Macrophage Differentiation Positive Regulation Of Metabolic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Phosphotyrosine Residue Binding Intrinsic Apoptotic Signaling Pathway In Response To Nitrosative Stress Guanyl-nucleotide Exchange Factor Adaptor Activity Nuclear Glucocorticoid Receptor Activity Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Cellular Response To Xenobiotic Stimulus Gland Development Negative Regulation Of Biosynthetic Process Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis
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