PXN and SORBS1

Number of citations of the paper that reports this interaction (PMID 17082770)
17

Data Source:
HPRD (in vivo, in vitro)

		PXN	SORBS1
Gene Name		paxillin	sorbin and SH3 domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft
	Molecular Function	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions	Smooth Muscle Contraction
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1	25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		5829	10580
HPRD ID		03937	05587
Ensembl ID		ENSG00000089159	ENSG00000095637
Uniprot IDs		E7EMK8 F5GZ78 P49023	Q9BX66
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN	2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion	Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?