PXN and CEACAM1

Number of citations of the paper that reports this interaction (PubMedID 11035932)
0

Data Source:
HPRD (in vitro, in vivo)

		PXN	CEACAM1
Description		paxillin	CEA cell adhesion molecule 1
Image
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Cytosol Cytoskeleton Microtubule Associated Complex Plasma Membrane Cell-cell Junction Focal Adhesion Cell Cortex Lamellipodium Anchoring Junction	Extracellular Region Plasma Membrane Cell-cell Junction Adherens Junction Basal Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Lateral Plasma Membrane Cell Junction Transport Vesicle Membrane Cytoplasmic Vesicle Microvillus Membrane Specific Granule Membrane T Cell Receptor Complex Cell Projection Extracellular Exosome Anchoring Junction Tertiary Granule Membrane
	Molecular Function	Protein Binding Beta-catenin Binding Vinculin Binding Protein Phosphatase Binding Neuropilin Binding Metal Ion Binding	Actin Binding Protein Binding Calmodulin Binding Bile Acid Transmembrane Transporter Activity Kinase Binding Protein Phosphatase Binding Filamin Binding Identical Protein Binding Protein Homodimerization Activity Protein Dimerization Activity Protein Tyrosine Kinase Binding
	Biological Process	Cell Adhesion Signal Transduction Signal Complex Assembly Transforming Growth Factor Beta Receptor Signaling Pathway Cell Migration Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Endothelial Cell Migration Positive Regulation Of Stress Fiber Assembly Growth Hormone Receptor Signaling Pathway	Angiogenesis Regulation Of Cell Growth Blood Vessel Development Negative Regulation Of T Cell Mediated Cytotoxicity Regulation Of Immune System Process Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Protein Kinase Activity Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Integrin-mediated Signaling Pathway Regulation Of Endothelial Cell Migration Bile Acid And Bile Salt Transport Cell Migration Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Interleukin-1 Production Cellular Response To Insulin Stimulus Common Myeloid Progenitor Cell Proliferation Insulin Receptor Internalization Granulocyte Colony-stimulating Factor Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Vascular Permeability Negative Regulation Of Cytotoxic T Cell Degranulation Wound Healing, Spreading Of Cells Regulation Of Endothelial Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Lipid Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Blood Vessel Remodeling Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Platelet Aggregation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Insulin Catabolic Process Regulation Of Homophilic Cell Adhesion Regulation Of Sprouting Angiogenesis Negative Regulation Of Hepatocyte Proliferation Positive Regulation Of Vasculogenesis
Pathways		GAB1 signalosome VEGFA-VEGFR2 Pathway Smooth Muscle Contraction Localization of the PINCH-ILK-PARVIN complex to focal adhesions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Fibronectin matrix formation Cell surface interactions at the vascular wall Neutrophil degranulation Regulation of MITF-M dependent genes involved in invasion
Drugs			Technetium Tc-99m arcitumomab
Diseases
GWAS		Bipolar disorder ( 31043756) Left ventricle wall thickness ( 33495596) Left ventricular end-systolic volume ( 33495596) Left ventricular mass to end-diastolic volume ratio ( 33495596) Mean spheric corpuscular volume ( 32888494) Platelet count ( 29403010)
Interacting Genes		86 interacting genes: ABL1 ACO1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 BLK CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK DPY30 EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGAV ITGB1 ITGB3 LCK LIMK1 LINC00632 LMO1 LMO3 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 PLEKHH2 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RHOU RNF5 SDC4 SELE SH3RF1 SORBS1 SRC SYK TCEANC TGM2 TLN1 TRIM15 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL WHRN	18 interacting genes: ADRB2 ANXA2 CARTPT CD209 CEACAM3 CEACAM5 CEACAM6 CEACAM7 CEACAM8 EGFR FLNA INSR MAP3K10 PTPN11 PTPN6 PXN SHC1 SRC
Entrez ID		5829	634
HPRD ID		03937	00191
Ensembl ID		ENSG00000089159	ENSG00000079385
Uniprot IDs		A0A140VJQ8 A0A1B0GTU4 F5GZ78 P49023	P13688 Q3KRG8
PDB IDs		1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2 5UWH 6IUI 6PW8 6U4M 6U4N 7QB0	2GK2 4QXW 4WHD 5DZL 6AW2 6GBG 6GBH 6V3P 6XNO 6XNT 6XNW 6XO1 7MU8 7RPP 8CXJ
Enriched GO Terms of Interacting Partners?		Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Adhesion Integrin-mediated Signaling Pathway Cell Migration Regulation Of Cellular Component Organization Cell Surface Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Anchoring Junction Cell Motility Regulation Of Cytoskeleton Organization Regulation Of Cell-substrate Adhesion Positive Regulation Of Cell Adhesion Regulation Of Cell Migration Regulation Of Intracellular Signal Transduction Cytosol Regulation Of Cell Motility Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Migration Regulation Of Locomotion Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway ERBB Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Phosphotyrosine Residue Binding Cell-substrate Adhesion Protein Kinase Activity Regulation Of Cell-matrix Adhesion Cell Projection Organization Regulation Of Immune System Process Lamellipodium Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction Cytoplasm Regulation Of MAPK Cascade Plasma Membrane Regulation Of Cellular Localization Regulation Of Protein Localization Immune Response-activating Signaling Pathway Immune Response-regulating Signaling Pathway Regulation Of Organelle Organization Kinase Activity Positive Regulation Of Immune System Process Fc-gamma Receptor Signaling Pathway	Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade Cell Adhesion Cell-cell Adhesion Positive Regulation Of Intracellular Signal Transduction Myeloid Cell Development Positive Regulation Of Signaling Negative Regulation Of Neutrophil Activation Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Positive Regulation Of Signal Transduction Plasma Membrane Cell Surface Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Vasodilation Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Signal Transduction Hemopoiesis Negative Regulation Of Anoikis Shc-EGFR Complex Regulation Of Intracellular Signal Transduction Negative Regulation Of Multicellular Organismal Process Positive Regulation Of ERK1 And ERK2 Cascade ERBB Signaling Pathway Megakaryocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Anoikis Negative Regulation Of Developmental Process Neutrophil Activation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Signaling Epidermal Growth Factor Binding Vascular Process In Circulatory System Regulation Of Apoptotic Process Side Of Membrane Symbiont Entry Into Host Cell Regulation Of Multicellular Organismal Process Regulation Of Programmed Cell Death Regulation Of Developmental Process Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Adhesion Protein Tyrosine Kinase Binding G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction T Cell Costimulation
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