PXN and ASAP2

Number of citations of the paper that reports this interaction (PMID 10749932)
25

Data Source:
HPRD (in vivo, in vitro)

		PXN	ASAP2
Gene Name		paxillin	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleoplasm Cytoplasm Cytosol Microtubule Associated Complex Plasma Membrane Focal Adhesion Cell Cortex Lamellipodium	Plasma Membrane Golgi Cisterna Membrane
	Molecular Function	Integrin Binding Protein Binding Beta-catenin Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding BH4 Domain Binding	Protein Binding Enzyme Activator Activity ARF GTPase Activator Activity Zinc Ion Binding
	Biological Process	Activation Of MAPK Activity Movement Of Cell Or Subcellular Component Muscle Contraction Cytoskeleton Organization Cell Adhesion Signal Transduction Signal Complex Assembly Epidermal Growth Factor Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Lamellipodium Assembly Cell Junction Assembly Substrate Adhesion-dependent Cell Spreading Cellular Response To Reactive Oxygen Species Vascular Endothelial Growth Factor Receptor Signaling Pathway Focal Adhesion Assembly Branching Morphogenesis Of An Epithelial Tube Growth Hormone Receptor Signaling Pathway	Regulation Of ARF GTPase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of GTPase Activity
Pathways		Cell junction organization GAB1 signalosome Smooth Muscle Contraction Signaling by Ligand-Responsive EGFR Variants in Cancer Signaling by EGFRvIII in Cancer Signaling by Overexpressed Wild-Type EGFR in Cancer VEGFA-VEGFR2 Pathway Signaling by EGFR Signaling by VEGF Regulation of cytoskeletal remodeling and cell spreading by IPP complex components Signaling by EGFR in Cancer Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions
Drugs
Diseases
GWAS
Protein-Protein Interactions		73 interactors: ABL1 AHCY AR ARHGEF7 ASAP1 ASAP2 BCAR1 BCL2 CASP3 CEACAM1 CLTC CREB3L2 CRK CRKL CSK DGUOK EPHB1 FYN GART GIT1 GIT2 GRB2 GSK3A GSK3B GSN HDAC6 ILK ITGA4 ITGA6 ITGA9 ITGB1 ITGB3 LCK LIMK1 MAPK1 MAPK3 MAPK8 MATK NCK1 NEDD9 NF2 PABPC1 PAK1 PAK3 PARVA PDPK1 PKD1 POLR1D PPP2CA PPP2R5C PTEN PTK2 PTK2B PTPN11 PTPN12 PTPRH RASA1 REPS2 RNF5 SDC4 SELE SORBS1 SRC SYK TLN1 TRIP6 TUBA1B TUBA3C TUBA8 TUBG1 TUBG2 VCL XPO1	13 interactors: ARF1 ARF5 ARF6 BIN1 GRB2 ITSN1 PACSIN3 PTK2B PXN RAN REPS2 SH3KBP1 THSD7A
Entrez ID		5829	8853
HPRD ID		03937	04820
Ensembl ID		ENSG00000089159	ENSG00000151693
Uniprot IDs		E7EMK8 F5GZ78 P49023	O43150
PDB IDs		1KKY 1KL0 1OW6 1OW7 1OW8 2K2R 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3C 3U3F 4EDN
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Cellular Component Organization Locomotion Movement Of Cell Or Subcellular Component Regulation Of Cell Adhesion Cell Morphogenesis Involved In Differentiation Response To Wounding Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Wound Healing Blood Coagulation Regulation Of Phosphorylation Hemostasis Cell Migration Response To External Stimulus Cell Projection Morphogenesis Axonogenesis Cell Part Morphogenesis Cell Morphogenesis Immune System Process Immune Response-regulating Signaling Pathway Neuron Projection Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Positive Regulation Of Catalytic Activity Axon Development Anatomical Structure Morphogenesis Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Signal Transduction Regulation Of Protein Kinase Activity Cell Surface Receptor Signaling Pathway Cell Projection Organization Regulation Of Phosphorus Metabolic Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Integrin-mediated Signaling Pathway Axon Guidance Positive Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Chemotaxis Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Catalytic Activity Regulation Of Kinase Activity Neuron Projection Development Response To Stress Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-substrate Adhesion	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Vesicle-mediated Transport Small GTPase Mediated Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Cytoskeleton Organization Cell Projection Organization Endocytosis Intracellular Signal Transduction Transport Positive Regulation Of Actin Filament Polymerization Signal Complex Assembly Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein Polymerization Regulation Of Vesicle-mediated Transport Signal Transduction Regulation Of Actin Filament-based Process Movement Of Cell Or Subcellular Component Signaling Regulation Of Cell Shape Cell Communication Focal Adhesion Assembly Positive Regulation Of Protein Complex Assembly Cell Differentiation Regulation Of Actin Filament Polymerization Regulation Of Cytoskeleton Organization Positive Regulation Of Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Viral Process Regulation Of Actin Filament Length Adherens Junction Assembly Negative Regulation Of Endocytosis Cell-substrate Junction Assembly Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Cellular Response To Stimulus Regulation Of Signaling Organelle Organization Positive Regulation Of Cellular Component Biogenesis Establishment Of Organelle Localization Regulation Of Cellular Component Size Regulation Of Protein Complex Assembly Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Adherens Junction Organization Positive Regulation Of Metabolic Process Generation Of Neurons
Tagcloud ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software
Tagcloud (Difference) ?		acclimatized adra1d altitude araf argef11 arhgap24 ascent cardiogenic circuitry cldn23 cldn6 ece1 ednra genic hape inciting map2k2 map2k7 mapk10 mylk oxphos pak3 pathoetiology plcb1 skew sos1 unacclimatized vasoconstriction vcam1	affy cdkn2a coexpressed coexpression constructed contructed david degs differential differentially disturbed dlk1 downloaded enrichment exploring gse26966 hub inositol itga4 mpp2 network networks obvious omnibus package phosphatidylinositol pituitary screened software
Tagcloud (Intersection) ?