TES and SOCS3

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TES	SOCS3
Gene Name		testis derived transcript (3 LIM domains)	suppressor of cytokine signaling 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Junction Protein Complex	Cytoplasm Cytosol
	Molecular Function	Zinc Ion Binding Poly(A) RNA Binding	Protein Kinase Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Cell Proliferation	Negative Regulation Of Protein Kinase Activity JAK-STAT Cascade Protein Ubiquitination Cytokine-mediated Signaling Pathway Regulation Of Growth Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Negative Regulation Of JAK-STAT Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Interferon-gamma-mediated Signaling Pathway Regulation Of Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Type I Interferon-mediated Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Branching Involved In Labyrinthine Layer Morphogenesis Placenta Blood Vessel Development Trophoblast Giant Cell Differentiation Spongiotrophoblast Differentiation
Pathways			Regulation of IFNA signaling Antigen processing: Ubiquitination & Proteasome degradation Interleukin-6 signaling Interferon Signaling Cytokine Signaling in Immune system Interferon gamma signaling Signaling by Interleukins Interferon alpha/beta signaling Class I MHC mediated antigen processing & presentation Regulation of IFNG signaling Growth hormone receptor signaling Adaptive Immune System Signaling by Leptin
Drugs
Diseases
GWAS			Blood trace element (Se levels) ( 23720494)
Protein-Protein Interactions		12 interactors: ACTL7A ACTN1 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	48 interactors: ACADVL APP BCL10 BIK CSF1R CSF3R CSNK1E CUEDC2 CXCR4 EGFR EPOR GFRA1 GHR HIVEP1 IGF1R IL12RB2 IL2RB IL6ST INSR IRS1 IRS2 JAK1 JAK2 JAK3 KIAA1958 LEPR MAP1S MAPK11 MAPK6 NME4 PDPK1 PIN1 PPP3CB PRLR PTK2 PTPN11 RASA1 RBMX RNF31 RPL7A SOCS2 TCEB1 TCEB2 TES TFDP1 TFR2 TXNDC11 YES1
Entrez ID		26136	9021
HPRD ID		05833	05006
Ensembl ID		ENSG00000135269	ENSG00000184557
Uniprot IDs		A4D0U5 Q9UGI8	O14543 Q6FI39
PDB IDs		2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Regulation Of Cytoskeleton Organization Cell Morphogenesis Regulation Of Actin Filament Polymerization Cellular Component Assembly Neuron Differentiation Cell Junction Assembly Regulation Of Actin Polymerization Or Depolymerization Cell Projection Organization Regulation Of Actin Filament Length Locomotion Organelle Organization Response To Stimulus Nervous System Development Cell-substrate Junction Assembly Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Bundle Assembly Generation Of Neurons Regulation Of Stress Fiber Assembly Regulation Of Protein Complex Assembly Protein Homotetramerization Signal Transduction Platelet Degranulation Actin Filament Reorganization Involved In Cell Cycle Neurogenesis Regulation Of Organelle Organization Signaling Cell Development Response To External Stimulus System Development	Cellular Response To Organic Substance Response To Organic Substance Cell Surface Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cytokine-mediated Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Cytokine Stimulus Response To Cytokine Growth Hormone Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Cellular Response To Stimulus Signal Transduction Response To Growth Hormone JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Cellular Response To Peptide Hormone Stimulus Regulation Of Signaling Cellular Response To Peptide Positive Regulation Of Signal Transduction Positive Regulation Of Cellular Metabolic Process Regulation Of Kinase Activity Peptidyl-tyrosine Phosphorylation Regulation Of Phosphorylation Signaling Cellular Response To Organonitrogen Compound Cell Communication Positive Regulation Of Phosphorylation Regulation Of Signal Transduction Regulation Of Phosphorus Metabolic Process Peptidyl-tyrosine Autophosphorylation Innate Immune Response Positive Regulation Of Transferase Activity Response To Peptide Hormone Cellular Response To Hormone Stimulus Response To Stimulus Positive Regulation Of Metabolic Process Regulation Of Protein Kinase Activity Protein Autophosphorylation Response To Peptide Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity JAK-STAT Cascade Positive Regulation Of Cellular Protein Metabolic Process Protein Phosphorylation Defense Response Regulation Of Immune Response Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Kinase Activity Positive Regulation Of Protein Modification Process
Tagcloud ?		apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara	activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Difference) ?		apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara	activates activator ameliorate attenuate autoimmune cd25lowcd44lowcd62lhigh cd4 coculture enhance fate h3k27me3 h3k4me3 immunomodulatory immunoregulatory inhibit interferon leading manifestations mesenchymal msc mscs promoters reciprocal rorgammat stat1 stat3 suppressors th17 transducer
Tagcloud (Intersection) ?