TES and ALKBH4

Number of citations of the paper that reports this interaction (PubMedID 23145062)
75

Data Source:
BioGRID (two hybrid)

		TES	ALKBH4
Description		testin LIM domain protein	alkB homolog 4, lysine demethylase
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Cell Junction Protein-containing Complex Anchoring Junction	Nucleus Nucleolus Cytoplasm Midbody Contractile Ring
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Cadherin Binding Metal Ion Binding	Actin Binding Protein Binding Oxidoreductase Activity 2-oxoglutarate-dependent Dioxygenase Activity Demethylase Activity Broad Specificity Oxidative DNA Demethylase Activity Metal Ion Binding Dioxygenase Activity Protein Demethylase Activity DNA N6-methyladenine Demethylase Activity
	Biological Process	Negative Regulation Of Cell Population Proliferation	Chromatin Organization Actomyosin Structure Organization Cleavage Furrow Ingression Demethylation Positive Regulation Of Gene Expression, Epigenetic
Pathways
Drugs
Diseases
GWAS		Chronotype ( 30696823) Glaucoma ( 30054594 31959993) Intraocular pressure ( 29235454 30054594 31959993) Metabolite levels ( 23823483) Schizophrenia, bipolar disorder or major depressive disorder ( 34099189) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction ( 34099189) Schizophrenia, bipolar disorder or recurrent major depressive disorder x sex interaction ( 34099189)	Morning person ( 30696823)
Interacting Genes		13 interacting genes: ACTL7A ACTN1 ALKBH4 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	19 interacting genes: BPIFA1 DTX2 EIF3C EP300 FAM168A GORASP2 HSF4 LCN2 MLLT1 MLLT3 MTMR6 NIF3L1 PSMA6 TCF4 TES TRAF4 TXNL4B WEE2-AS1 ZFHX3
Entrez ID		26136	54784
HPRD ID		05833	07875
Ensembl ID		ENSG00000135269	ENSG00000160993
Uniprot IDs		A4D0U5 Q9UGI8	Q9NXW9
PDB IDs		2IYB 2XQN
Enriched GO Terms of Interacting Partners?		Actin Binding Actin Filament Organization Supramolecular Fiber Organization Profilin Binding Cytoskeleton Organization Actin Cytoskeleton Organization Actin Filament-based Process Anchoring Junction Focal Adhesion Cell Projection Cytoskeleton Actin Polymerization Or Depolymerization Vinculin Binding Stress Fiber Regulation Of Actin Filament Organization Structural Constituent Of Cytoskeleton Ruffle SH3 Domain Binding Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Polymerization Organelle Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Lamellipodium Cell-substrate Junction Assembly Actin Filament Binding Cell-substrate Junction Organization Regulation Of Cytoskeleton Organization Neuron Projection Guidance Axon Guidance Platelet Aggregation Positive Regulation Of Actin Filament Polymerization DNA N6-methyladenine Demethylase Activity Extrinsic Component Of Postsynaptic Early Endosome Membrane Regulation Of Recycling Endosome Localization Within Postsynapse Cortical Actin Cytoskeleton Cellular Component Assembly Regulation Of Cellular Component Size Cell Junction Assembly Cytosol Protein Homotetramerization Actin Filament Bundle Assembly Homotypic Cell-cell Adhesion Actin Cytoskeleton Actin Filament Bundle Organization Structural Constituent Of Postsynapse Cleavage Furrow Ingression Negative Regulation Of Receptor Clustering
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