TES and TLN1

Number of citations of the paper that reports this interaction (PMID 12695497)
15

Data Source:
HPRD (in vitro, in vivo)

		TES	TLN1
Gene Name		testis derived transcript (3 LIM domains)	talin 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane Focal Adhesion Cell Junction Protein Complex	Ruffle Extracellular Region Cytoplasm Microtubule Organizing Center Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Cell Surface Ruffle Membrane Extracellular Vesicular Exosome
	Molecular Function	Zinc Ion Binding Poly(A) RNA Binding	Insulin Receptor Binding Integrin Binding Structural Constituent Of Cytoskeleton Protein Binding Vinculin Binding LIM Domain Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Cell Proliferation	Platelet Degranulation Movement Of Cell Or Subcellular Component Muscle Contraction Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Cytoskeletal Anchoring At Plasma Membrane Cell-cell Junction Assembly Cell-substrate Junction Assembly Axon Guidance Blood Coagulation Platelet Activation Cortical Actin Cytoskeleton Organization Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Platelet Aggregation
Pathways			Axon guidance Semaphorin interactions p130Cas linkage to MAPK signaling for integrins Smooth Muscle Contraction Integrin alphaIIb beta3 signaling Platelet degranulation GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet Aggregation (Plug Formation) XBP1(S) activates chaperone genes IRE1alpha activates chaperones Response to elevated platelet cytosolic Ca2+ SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion Platelet activation, signaling and aggregation Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		12 interactors: ACTL7A ACTN1 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	23 interactors: ACTA1 CDK5 DAG1 EGFR ERBB2 ITGA1 ITGA2B ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 LRP2 NRAP PKD1 PTK2 PTK2B PXN SMURF1 TES TUBA1A VCL YWHAQ
Entrez ID		26136	7094
HPRD ID		05833	01726
Ensembl ID		ENSG00000135269	ENSG00000137076
Uniprot IDs		A4D0U5 Q9UGI8	Q9Y490
PDB IDs		2IYB 2XQN	1SYQ 4DJ9
Enriched GO Terms of Interacting Partners?		Actin Filament Organization Actin Cytoskeleton Organization Actin Filament-based Process Cytoskeleton Organization Axon Guidance Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Actin Polymerization Or Depolymerization Cell Morphogenesis Involved In Differentiation Regulation Of Actin Cytoskeleton Organization Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Actin Filament-based Process Neuron Development Regulation Of Cytoskeleton Organization Cell Morphogenesis Regulation Of Actin Filament Polymerization Cellular Component Assembly Neuron Differentiation Cell Junction Assembly Regulation Of Actin Polymerization Or Depolymerization Cell Projection Organization Regulation Of Actin Filament Length Locomotion Organelle Organization Response To Stimulus Nervous System Development Cell-substrate Junction Assembly Movement Of Cell Or Subcellular Component Anatomical Structure Morphogenesis Positive Regulation Of Cellular Component Biogenesis Regulation Of Cellular Component Size Actin Filament Bundle Assembly Generation Of Neurons Regulation Of Stress Fiber Assembly Regulation Of Protein Complex Assembly Protein Homotetramerization Signal Transduction Platelet Degranulation Actin Filament Reorganization Involved In Cell Cycle Neurogenesis Regulation Of Organelle Organization Signaling Cell Development Response To External Stimulus System Development	Cell-matrix Adhesion Cell-substrate Adhesion Integrin-mediated Signaling Pathway Movement Of Cell Or Subcellular Component Cell Adhesion Cell Morphogenesis Involved In Differentiation Anatomical Structure Morphogenesis Response To External Stimulus Cell Differentiation Axonogenesis Anatomical Structure Development Extracellular Matrix Organization Extracellular Structure Organization Axon Development Cell Morphogenesis Axon Guidance Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Development Regulation Of Cell Migration Chemotaxis Cell Development Cell Projection Organization Neuron Projection Morphogenesis Regulation Of Cell Motility Developmental Process Multicellular Organismal Development Positive Regulation Of Protein Kinase Activity Regulation Of Locomotion Locomotion Neuron Development Regulation Of Cellular Component Movement Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorylation Single Organismal Cell-cell Adhesion Regulation Of Protein Phosphorylation Positive Regulation Of Transferase Activity Neuron Differentiation Cell Projection Morphogenesis Nervous System Development Regulation Of Phosphorus Metabolic Process Cell Part Morphogenesis Positive Regulation Of Phosphorylation Wound Healing Positive Regulation Of Protein Modification Process Generation Of Neurons Blood Coagulation Cellular Localization Hemostasis Heterotypic Cell-cell Adhesion
Tagcloud ?		apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara	83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Difference) ?		apoprotein caenorhabditis canis coat constituent cys displays elegans evasion heptameric homogeneous hyperabundant immunosuppression infective interspersed larvae leader mucin mucins nematode nematodes organized parasitic proline repeats shed sl1 spliced toxocara	83a adjacent brainstem clu comprehensive correlating dipg dipgs ef2 fresh frozen glioma h3f3a hedgehog hh hist1h3b hypomethylation morbid multidimensional pediatric pontine profiling ptch signatures specimens subgroups supervised talin upregulation
Tagcloud (Intersection) ?