APPL1 and PLEKHF2

Number of citations of the paper that reports this interaction (PMID 19060904)
157

Data Source:
BioGRID (two hybrid)

		APPL1	PLEKHF2
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	pleckstrin homology domain containing, family F (with FYVE domain) member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	Protein Binding Metal Ion Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	Protein Transport
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS			Radiation response ( 20923822)
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	52 interactors: ACY3 AIMP2 APP APPL1 BEND7 BLOC1S6 BSCL2 CCDC85B CEP44 CHIC2 DTX2 DUT FBXO28 FHL3 FRMD8 GFER GLUL GNMT GPBP1 GPBP1L1 HSPB7 L3MBTL3 LDOC1 MAX MBIP MEAF6 NONO NPM2 PRKAR1A PRPSAP1 RABAC1 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SDPR SEPT2 SEPT6 SETBP1 SFN SPEF1 TNFAIP8 TRAF6 TRAPPC3 TSC22D3 TXNL4B UBE2Z ZNF250 ZNF263 ZNF398
Entrez ID		26060	79666
HPRD ID		05053	15147
Ensembl ID		ENSG00000157500	ENSG00000175895
Uniprot IDs		Q9UKG1	Q9H8W4
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Apoptotic Process Programmed Cell Death Cell Death Death Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	abnormally attempt cargo colocalized concert depleted dextran discover eea1 effectors egf endosomal endosome endosomes enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments employ endocytic engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	abnormally attempt cargo colocalized concert depleted dextran discover effectors egf endosomal enlarged facilitating fyve interactor microdomains mtmr4 orchestrates phafin2 proteome ptdins3p px recruiting screen termination tethering
Tagcloud (Intersection) ?		eea1 endosome endosomes