APPL1 and RAB21

Number of citations of the paper that reports this interaction (PMID 17581628)
38

Data Source:
BioGRID (pull down)

		APPL1	RAB21
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	RAB21, member RAS oncogene family
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Endosome Early Endosome Endoplasmic Reticulum Membrane Trans-Golgi Network Focal Adhesion Cytoplasmic Side Of Plasma Membrane Vesicle Membrane Cytoplasmic Vesicle Membrane Cleavage Furrow Golgi Cisterna Membrane Extracellular Vesicular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	Intracellular Protein Transport Metabolic Process Regulation Of Exocytosis Regulation Of Endocytosis Rab Protein Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	2 interactors: APPL1 RABGEF1
Entrez ID		26060	23011
HPRD ID		05053	06695
Ensembl ID		ENSG00000157500
Uniprot IDs		Q9UKG1	Q9UL25
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O	1YZT 1YZU 1Z08 1Z0I 2OT3
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process See more	Negative Regulation Of Kit Signaling Pathway Negative Regulation Of Mast Cell Degranulation Negative Regulation Of Interleukin-6 Secretion Negative Regulation Of Mast Cell Activation Involved In Immune Response Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Regulation Of Establishment Of Protein Localization Negative Regulation Of Mast Cell Activation Regulation Of Protein Localization Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Leukocyte Migration Regulation Of Cellular Localization Regulation Of Mast Cell Degranulation Regulation Of Mast Cell Activation Negative Regulation Of Cytokine Secretion Negative Regulation Of Interleukin-6 Production Negative Regulation Of Exocytosis Negative Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Regulated Secretory Pathway Negative Regulation Of Response To Cytokine Stimulus Regulation Of Establishment Of Protein Localization To Plasma Membrane Negative Regulation Of Endocytosis Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Ras Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Glucose Import Regulation Of Cellular Component Organization Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Protein Secretion Regulation Of Glucose Transport Regulation Of Interleukin-6 Production Negative Regulation Of Inflammatory Response Regulation Of Leukocyte Migration Negative Regulation Of Intracellular Transport Positive Regulation Of Rab GTPase Activity Negative Regulation Of Immune Response Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Regulation Of Cytokine Secretion Insulin Receptor Signaling Pathway Regulation Of Exocytosis Negative Regulation Of Leukocyte Activation Protein Targeting To Membrane Negative Regulation Of Secretion By Cell Negative Regulation Of Secretion Negative Regulation Of Protein Transport Regulation Of Endocytosis See more
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	abl adamtsl4 baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	abl adamtsl4 baalc bcr cd83 ciita council ctnnd1 e2993 gab1 gli1 hubs il15 irs1 p185bcr p210bcr pilrb ptp4a3 serpinb9 spp1 spry1 supervised transcriptomic tspan16 ukall underexpressed unsupervised xbp1 xii
Tagcloud (Intersection) ?