APPL1 and RAB21

Number of citations of the paper that reports this interaction (PubMedID 17581628)
32

Data Source:
BioGRID (pull down)

		APPL1	RAB21
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	RAB21, member RAS oncogene family
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse	Golgi Membrane Endosome Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Focal Adhesion Cytoplasmic Side Of Plasma Membrane Endomembrane System Vesicle Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Cleavage Furrow Golgi Cisterna Membrane Cell Projection Neuron Projection Synapse Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane Axon Cytoplasm
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding
	Biological Process	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Intracellular Protein Transport Anterograde Axonal Transport Protein Transport Regulation Of Exocytosis Regulation Of Axon Extension Rab Protein Signal Transduction Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Dendrite Morphogenesis Protein Stabilization Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS			Adult body size ( 32376654) Apolipoprotein B levels ( 32203549) Body mass index ( 29273807) General cognitive ability ( 29844566) HDL cholesterol levels ( 32759990) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731)
Interacting Genes		72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829	1 interacting genes: APPL1
Entrez ID		26060	23011
HPRD ID		05053	06695
Ensembl ID		ENSG00000157500	ENSG00000080371
Uniprot IDs		Q9UKG1	Q9UL25
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B	1YZT 1YZU 1Z08 1Z0I 2OT3
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process	Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Melanin Biosynthetic Process Positive Regulation Of Pinocytosis Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Macropinosome Cellular Response To Hepatocyte Growth Factor Stimulus Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Adiponectin-activated Signaling Pathway Response To Hepatocyte Growth Factor Intracellular Vesicle Negative Regulation Of Phagocytosis Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of D-glucose Import Vesicle Membrane Regulation Of Fibroblast Migration Beta-tubulin Binding Positive Regulation Of D-glucose Transmembrane Transport Cell Junction Maintenance Phosphatidylserine Binding Regulation Of D-glucose Import Cellular Component Maintenance Negative Regulation Of Endocytosis Regulation Of D-glucose Transmembrane Transport Regulation Of Cytokine Production Involved In Inflammatory Response Insulin Receptor Signaling Pathway Phagocytic Vesicle Regulation Of Phagocytosis Transforming Growth Factor Beta Receptor Signaling Pathway Ruffle Phosphatidylinositol Binding Regulation Of Protein Localization To Plasma Membrane Protein Import Into Nucleus Import Into Nucleus Hormone-mediated Signaling Pathway Positive Regulation Of Endocytosis Regulation Of Protein Localization To Cell Periphery Regulation Of G1/S Transition Of Mitotic Cell Cycle Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Protein Localization To Nucleus Regulation Of Protein Localization To Membrane Regulation Of Cell Cycle G1/S Phase Transition Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Early Endosome Membrane Nuclear Transport Nucleocytoplasmic Transport
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