APPL1 and ADIPOR1

Number of citations of the paper that reports this interaction (PMID 16622416)
118

Data Source:
BioGRID (two hybrid, protein complementation assay)
HPRD (in vitro, in vivo, two hybrid)

		APPL1	ADIPOR1
Gene Name		adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1	adiponectin receptor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Endosome Membrane Vesicle Membrane NuRD Complex Early Endosome Membrane Extracellular Vesicular Exosome	Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Identical Protein Binding Protein Kinase B Binding	Receptor Activity Protein Kinase Binding Hormone Binding Identical Protein Binding Protein Heterodimerization Activity Adiponectin Binding
	Biological Process	Cell Cycle Signal Transduction Cell Proliferation Insulin Receptor Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Glucose Import Regulation Of Establishment Of Protein Localization To Plasma Membrane Apoptotic Signaling Pathway	Hormone-mediated Signaling Pathway Fatty Acid Oxidation Negative Regulation Of Cell Growth Leptin-mediated Signaling Pathway Adiponectin-activated Signaling Pathway Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Insulin Receptor Signaling Pathway
Pathways		Programmed Cell Death Role of DCC in regulating apoptosis Extrinsic Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: ADIPOR1 AKT1 AKT2 APPL2 CMTM4 DCC DPYSL5 EGFR FARS2 FSHR HDAC1 HDAC2 KXD1 MAGEA9 MEOX1 MTA2 PIK3CA PLEKHF2 RAB21 RAB5A RBBP7 RHEBL1 RUVBL2 TRAF2 UBE2O	5 interactors: APLP2 APPL1 DPH3 NAA20 NFKBIL1
Entrez ID		26060	51094
HPRD ID		05053	06402
Ensembl ID		ENSG00000157500	ENSG00000159346
Uniprot IDs		Q9UKG1	Q96A54
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O
Enriched GO Terms of Interacting Partners?		ATP-dependent Chromatin Remodeling Chromatin Remodeling Regulation Of Growth Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Tongue Development Negative Regulation Of Plasma Membrane Long-chain Fatty Acid Transport Regulation Of Cellular Ketone Metabolic Process Response To UV-A Cellular Response To Hormone Stimulus Positive Regulation Of Cellular Metabolic Process Cell Surface Receptor Signaling Pathway Fungiform Papilla Formation Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stimulus Histone Deacetylation Protein Deacetylation Signal Transduction Fungiform Papilla Morphogenesis Regulation Of Cellular Amino Acid Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Receptor Biosynthetic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Fungiform Papilla Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Regulation Of Gene Expression, Epigenetic Blood Coagulation Negative Regulation Of Gene Expression, Epigenetic Peripheral Nervous System Myelin Maintenance Eyelid Development In Camera-type Eye Hemostasis Regulation Of Cellular Component Organization Positive Regulation Of Intracellular Transport Positive Regulation Of Glycogen Biosynthetic Process Hair Follicle Placode Formation Positive Regulation Of Macromolecule Biosynthetic Process Signaling Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Growth Hair Follicle Development Response To Organic Substance Hair Cycle Process Regulation Of Signaling Tongue Morphogenesis Cell Communication Response To Stimulus Glial Cell Development Regulation Of Receptor Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process	Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Negative Regulation Of Protein Transport Regulation Of Cellular Localization N-terminal Peptidyl-methionine Acetylation Regulation Of Binding Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Peptidyl-methionine Modification N-terminal Protein Amino Acid Acetylation Negative Regulation Of Transport Peptidyl-diphthamide Biosynthetic Process From Peptidyl-histidine
Tagcloud ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	activate ampk appreciated benign decreases depletion endothelial healthy hyperplasia inhibit mtor neovascularization plasma prostate prostatic remain resected seemed specimen subjects suppressing taken tsc2 tumorigenesis underlying unknown vascular vegf
Tagcloud (Difference) ?		characterised colocalisation colocalises compartments eea1 employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	activate ampk appreciated benign decreases depletion endothelial healthy hyperplasia inhibit mtor neovascularization plasma prostate prostatic remain resected seemed specimen subjects suppressing taken tsc2 tumorigenesis underlying unknown vascular vegf
Tagcloud (Intersection) ?