PLEKHF2 and INO80

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PLEKHF2	INO80
Description		pleckstrin homology and FYVE domain containing 2	INO80 complex ATPase subunit
Image		No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Endoplasmic Reticulum Endomembrane System Membrane Transport Vesicle Cytoplasmic Vesicle Early Endosome Membrane	Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Nuclear Body Ino80 Complex
	Molecular Function	Protein Binding Zinc Ion Binding Phosphatidylinositol Binding Metal Ion Binding	Nucleotide Binding DNA Binding Actin Binding Protein Binding ATP Binding ATP-dependent Activity, Acting On DNA Hydrolase Activity ATP Hydrolysis Activity Histone Binding Alpha-tubulin Binding ATP-dependent Chromatin Remodeler Activity
	Biological Process	Endosome Organization Endosome To Lysosome Transport Protein Transport	Mitotic Sister Chromatid Segregation Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair Double-strand Break Repair DNA Recombination Chromatin Remodeling DNA-templated Transcription DNA Damage Response Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Cell Growth Regulation Of Chromosome Organization Cellular Response To UV Positive Regulation Of DNA Repair Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Embryonic Development Positive Regulation Of DNA Metabolic Process Spindle Assembly Chromosome Organization Cell Division Regulation Of Cell Cycle Regulation Of DNA Strand Elongation UV-damage Excision Repair Cellular Response To Ionizing Radiation Positive Regulation Of Telomere Maintenance In Response To DNA Damage Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways			UCH proteinases DNA Damage Recognition in GG-NER
Drugs
Diseases
GWAS		Radiation response ( 20923822)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Appendicular lean mass ( 33097823) Diastolic blood pressure ( 27841878) Estimated glomerular filtration rate ( 31451708 31152163) Estimated glomerular filtration rate in non-diabetics ( 31451708) Frailty index ( 34431594) Glomerular filtration rate (creatinine) ( 26831199 28452372) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Macular thickness ( 30535121) Malaria ( 31844061) Menopause (age at onset) ( 26414677) Offspring birth weight ( 31043758) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Systolic blood pressure ( 27841878) Ulcerative colitis ( 28067908)
Interacting Genes		168 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HSPB7 INO80 KCNAB3 KCNJ5-AS1 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581	2 interacting genes: ACTN4 PLEKHF2
Entrez ID		79666	54617
HPRD ID		15147	10024
Ensembl ID		ENSG00000175895	ENSG00000128908
Uniprot IDs		Q9H8W4	Q9ULG1
PDB IDs			6HTS 7ZI4
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Endoplasmic Reticulum Tubular Network Formation	Nucleoside Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Sodium Ion Transmembrane Transporter Activity Postsynaptic Actin Cytoskeleton Positive Regulation Of Sodium:proton Antiporter Activity Positive Regulation Of Sodium Ion Transmembrane Transport Vesicle Transport Along Actin Filament Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Pseudopodium Retinoic Acid Receptor Signaling Pathway Vesicle Cytoskeletal Trafficking Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Substrate Adhesion-dependent Cell Spreading Platelet Alpha Granule Lumen Cellular Localization Tumor Necrosis Factor-mediated Signaling Pathway Protein Transport Establishment Of Protein Localization Positive Regulation Of Transporter Activity Nuclear Receptor Binding Positive Regulation Of Sodium Ion Transport Regulation Of Sodium Ion Transport Actin Filament-based Movement Cortical Actin Cytoskeleton Establishment Of Localization In Cell Negative Regulation Of Cell-substrate Adhesion Intracellular Transport Endosome To Lysosome Transport Regulation Of Transmembrane Transporter Activity Muscle Cell Development Chromatin DNA Binding Intracellular Protein Localization Nuclear Receptor-mediated Signaling Pathway Regulation Of Monoatomic Ion Transmembrane Transporter Activity Stress Fiber Regulation Of Non-canonical NF-kappaB Signal Transduction Transport Vesicle Endosome Organization Establishment Of Vesicle Localization Phosphatidylinositol Binding Positive Regulation Of Cation Transmembrane Transport Vesicle Localization Positive Regulation Of Monoatomic Ion Transmembrane Transport Lysosomal Transport
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