APPL1 and DOK7

Number of citations of the paper that reports this interaction (PubMedID 25814554)
62

Data Source:
BioGRID (two hybrid)

		APPL1	DOK7
Description		adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	docking protein 7
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Endosome Membrane Vesicle Membrane Actin Cytoskeleton Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Cell Projection Macropinosome Phagocytic Vesicle Extracellular Exosome Intracellular Vesicle Glutamatergic Synapse	Nucleoplasm Mitochondrion Plasma Membrane Membrane Neuromuscular Junction Synapse Postsynaptic Membrane
	Molecular Function	Phosphatidylserine Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding Protein Homodimerization Activity Protein Kinase B Binding Protein-containing Complex Binding Beta-tubulin Binding	Protein Binding Lipid Binding Protein Kinase Binding Phosphatidylinositol Binding Signaling Adaptor Activity
	Biological Process	Protein Import Into Nucleus Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Insulin Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Regulation Of Fibroblast Migration Signaling Adiponectin-activated Signaling Pathway Regulation Of Toll-like Receptor 4 Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Regulation Of Innate Immune Response Regulation Of D-glucose Import Positive Regulation Of D-glucose Import Positive Regulation Of Melanin Biosynthetic Process Positive Regulation Of Transport Maintenance Of Synapse Structure Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Macropinocytosis Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of G1/S Transition Of Mitotic Cell Cycle	Enzyme-linked Receptor Protein Signaling Pathway Neuromuscular Junction Development Positive Regulation Of Rac Protein Signal Transduction Receptor Clustering Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Caspase activation via Dependence Receptors in the absence of ligand
Drugs
Diseases			Congenital myasthenic syndrome Fetal akinesia deformation sequence (FADS); Pena-Shokeir syndrome, type 1
GWAS			Calcium levels ( 29403010) Coronary artery disease ( 33020668) Fibrinogen levels ( 28107422) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Spondylosis ( 33332786)
Interacting Genes		72 interacting genes: ADI1 ADIPOR1 ADIPOR2 AGL AKT1 AKT2 ANKRD1 APPL2 ATP2A1 BATF3 BIN1 BRWD1 C1QTNF9 CBL CBLB CIPC CMTM4 CTTNBP2 DACT1 DCC DNM2 DOK2 DOK3 DOK7 DPYSL5 DTNA DYSF EGFR FARS2 FSHR GABARAP GABARAPL1 GABARAPL2 GPC3 HDAC2 HSPB1 ID1 INO80E KLF15 KXD1 LUC7L MAGEA9 MAGEC3 MAP1LC3A MAP1LC3B MAP1LC3C MAP3K1 MEOX1 MTA2 MYCBP2 MYH3 PIK3CA PIK3R1 PIK3R2 PLEKHF2 PNMA5 RAB21 RAB5A RBBP7 RHEBL1 RSPH1 RUVBL2 SCAPER SH2D2A SOCS6 SPART TP53 TP53BP2 TRAF2 UBC UBE2O ZNF829	8 interacting genes: APPL1 BCAR1 CRK EFEMP2 EFHC1 MPZL1 MUSK YPEL3
Entrez ID		26060	285489
HPRD ID		05053	08744
Ensembl ID		ENSG00000157500	ENSG00000175920
Uniprot IDs		Q9UKG1	A0A1W2PRA3 A0A2R8Y701 Q18PE1 Q8N1M3
PDB IDs		2EJ8 2ELA 2ELB 2Q12 2Q13 2Z0N 2Z0O 5C5B
Enriched GO Terms of Interacting Partners?		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Mitophagy Autophagy Of Mitochondrion Phospholipid Binding Ubiquitin Protein Ligase Binding Autophagosome Maturation Cytosol Regulation Of Cellular Component Organization Autophagosome Membrane Signal Transduction Regulation Of D-glucose Import Endomembrane System Cell Surface Receptor Signaling Pathway Positive Regulation Of D-glucose Import Response To Starvation Macroautophagy Protein Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Protein Localization To Membrane Regulation Of D-glucose Transmembrane Transport Positive Regulation Of D-glucose Transmembrane Transport Cellular Response To Starvation Autophagosome Regulation Of Growth Negative Regulation Of Multicellular Organismal Process Glucose Homeostasis Carbohydrate Homeostasis Intracellular Signaling Cassette Protein-containing Complex Disassembly Intracellular Signal Transduction Autophagosome Assembly Adiponectin-activated Signaling Pathway Cytoplasm Autophagy Autophagosome Organization Cellular Response To Stress Phosphatidylinositol 3-kinase Regulatory Subunit Binding Phosphatidylinositol 3-kinase Complex, Class IA Regulation Of Cellular Localization Rhythmic Process Cellular Response To Nutrient Levels Establishment Of Protein Localization Histone Deacetylase Binding Insulin Receptor Signaling Pathway Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Protein Localization To Membrane Response To Nutrient Levels Regulation Of Developmental Process	Response To Hepatocyte Growth Factor Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Cellular Response To Hepatocyte Growth Factor Stimulus Cellular Response To Growth Factor Stimulus Actin Cytoskeleton Response To Growth Factor Positive Regulation Of Protein Geranylgeranylation Negative Regulation Of Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Smooth Muscle Cell-matrix Adhesion Neuromuscular Junction Insulin Receptor Signaling Pathway Helper T Cell Diapedesis Cell Surface Receptor Signaling Pathway Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Positive Regulation Of Macropinocytosis Positive Regulation Of Aortic Smooth Muscle Cell Differentiation Ruffle SH3 Domain Binding Cerebellar Neuron Development Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Collagen Fibril Organization Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Growth Regulation Of Cellular Component Organization Macropinosome Elastic Fiber Regulation Of Protein Localization To Membrane Aorta Smooth Muscle Tissue Morphogenesis Diapedesis Positive Regulation Of Pinocytosis Cell Chemotaxis Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Positive Regulation Of Receptor Clustering Cellular Response To Insulin-like Growth Factor Stimulus Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Reelin-mediated Signaling Pathway Response To Endothelin Cellular Response To Endothelin Regulation Of Cell-substrate Adhesion Postsynaptic Specialization Assembly Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Synaptic Assembly At Neuromuscular Junction Endothelin Receptor Signaling Pathway Hepatocyte Growth Factor Receptor Signaling Pathway Early Phagosome Positive Regulation Of Melanin Biosynthetic Process Protein Kinase B Binding Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
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